Systematic review: the efficacy of intermittent and on‐demand therapy with histamine H2‐receptor antagonists or proton pump inhibitors for gastro‐oesophageal reflux disease patients

The Impact of Gastroesophageal Reflux Disease on Health-related Quality of Life 11Supported by research funding from Astra/Merck, Wayne, Pennsylvania.

1998 • 436 citations

Heartburn without Oesophagitis: Efficacy of Omeprazole Therapy and Features Determining Therapeutic Response

1997 • 424 citations

Nonerosive Reflux Disease— Current Concepts and Dilemmas

2001 • 270 citations

On demand therapy with omeprazole for the long‐term management of patients with heartburn without oesophagitis—a placebo‐controlled randomized trial

1999 • 203 citations

Esomeprazole 20 mg maintains symptom control in endoscopy‐negative gastro‐oesophageal reflux disease: a controlled trial of ‘on‐demand’ therapy for 6 months

2001 • 187 citations

Omeprazole v ranitidine for prevention of relapse in reflux oesophagitis. A controlled double blind trial of their efficacy and safety.

1994 • 187 citations

Three year follow up of patients with gastrooesophageal reflux disease.

1992 • 163 citations

Upper gastrointestinal symptoms in North America: prevalence and relationship to healthcare utilization and quality of life.

2000 • 163 citations

Methodological Aspects of Evaluation of Quality of Life in Upper Gastrointestinal Diseases

1993 • 161 citations

Who is using chronic acid suppression therapy and why?

2003 • 144 citations

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine

1999 • 139 citations

Epidemiology and Pathophysiology of Symptomatic Gastroesophageal Reflux Disease

2003 • 137 citations

Factors influencing compliance in long-term proton pump inhibitor therapy in general practice.

1999 • 126 citations

Quality of life during acute and intermittent treatment of gastro-oesophageal reflux disease with omeprazole compared with ranitidine. Results from a multicentre clinical trial. The European Study Group.

1998 • 118 citations

Esomeprazole 40 mg and 20 mg is efficacious in the long-term management of patients with endoscopy-negative gastro-oesophageal reflux disease: a placebo-controlled trial of on-demand therapy for 6 months

2002 • 115 citations

Long-Term Efficacy of Total (Nissen-Rossetti) and Posterior Partial (Toupet) Fundoplication Results of a Randomized Clinical Trial

2002 • 114 citations

Long term acid suppressing treatment in general practice

1994 • 106 citations

Proton pump inhibitors in acute healing and maintenance of erosive or worse esophagitis: a systematic overview.

1997 • 86 citations

Six‐month trial of on‐demand rabeprazole 10 mg maintains symptom relief in patients with non‐erosive reflux disease

2004 • 86 citations

Bolus or Intravenous Infusion of Ranitidine: Effects on Gastric pH and Acid Secretion

1990 • 81 citations

Intermittent treatment of duodenal ulcer with cimetidine.

1980 • 69 citations

Esomeprazole 20 mg on‐demand is more acceptable to patients than continuous lansoprazole 15 mg in the long‐term maintenance of endoscopy‐negative gastro‐oesophageal reflux patients: the COMMAND Study

2004 • 67 citations

Demonstration of the efficacy of ginkgo biloba special extract EGb 761 on intermittent claudication-a placebo-controlled, double-blind multicenter trial

1999 • 66 citations

Reflux during positive pressure ventilation through the laryngeal mask

1994 • 55 citations

On-Demand Treatment in Patients with Oesophagitis and Reflux Symptoms: Comparison of Lansoprazole and Omeprazole

2002 • 52 citations

Intermittent and on-Demand Use of Proton Pump Inhibitors in The Management of Symptomatic Gastroesophageal Reflux Disease

2003 • 51 citations

Holding the baby: head downwards positioning for physiotherapy does not cause gastro-oesophageal reflux

1998 • 51 citations

Costs and efficacy of three different esomeprazole treatment strategies for long‐term management of gastro‐oesophageal reflux symptoms in primary care

2004 • 51 citations

Omeprazole 20 mg three days a week and 10 mg daily in prevention of duodenal ulcer relapse

1991 • 48 citations

Cost Effectiveness of Omeprazole and Ranitidine in Intermittent Treatment of Symptomatic Gastro-Oesophageal Reflux Disease

1999 • 47 citations

Gastro‐oesophageal reflux during day case gynaecological laparoscopy under positive pressure ventilation: laryngeal mask vs. tracheal intubation

1998 • 45 citations

Proton Pump Inhibitors and the Time Trends for Esophageal Dilation

2004 • 41 citations

On-Demand Therapy with Rabeprazole in Nonerosive and Erosive Gastroesophageal Reflux Disease in Clinical Practice: Effectiveness, Health-Related Quality of Life, and Patient Satisfaction

2004 • 40 citations

Prescribing of antacids and ulcer‐healing drugs in primary care in the north of England

1995 • 39 citations

On‐demand treatment of gastro‐oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placebo

1998 • 38 citations

SELF-DIRECTED TREATMENT OF INTERMITTENT HEARTBURN

1995 • 37 citations

Cimetidine On-Demand in Dyspepsia Experience with Randomized Controlled Single-Subject Trials

1992 • 33 citations

On-demand therapy for gastro-oesophageal reflux disease.

2001 • 32 citations

Sufficient control of heartburn in endoscopy‐negative gastro‐oesophageal reflux disease trials

2003 • 30 citations

Treatment of HIV-related cytomegalovirus disease of the gastrointestinal tract with foscarnet.

1992 • 30 citations

Ambulatory oesophageal pressure, pH and ECG recording in patients with normal and pathological coronary angiography and intermittent chest pain

1995 • 27 citations

Daily omeprazole surpasses intermittent dosing in preventing relapse of oesophagitis: a US multi‐centre double‐blind study

1997 • 25 citations

A Quality of Life Study in Five Hundred and Eighty-one Duodenal Ulcer Patients Maintenance versus Intermittent Treatment with Nizatidine

1994 • 25 citations

THE USE OF LONG‐TERM ACID‐SUPPRESSION THERAPY

1995 • 25 citations

Post‐prandial ranitidine is superior to post‐prandial omeprazole in control of gastric acidity in healthy volunteers

1999 • 25 citations

Does mechanical ventilation precipitate gastro-oesophageal reflux during enteral feeding?

1989 • 23 citations

Long term management of duodenal ulcer in general practice: How best to use cimetidine?

1988 • 22 citations

Onset of action during on‐demand treatment with Maalox suspension or low‐dose ranitidine for heartburn

1999 • 21 citations

On-demand therapy in gastroesophageal reflux disease: a comparison of the early effects of single doses of fast-dissolving famotidine wafers and ranitidine tablets

1997 • 19 citations

Helicobacter pylori: From Bench to Bedside

1997 • 19 citations

Conventional versus on-demand therapy for duodenal ulcer: results of a controlled therapeutic trial.

1990 • 17 citations

Comparison of the effect on intragastric pH of a single dose of omeprazole or rabeprazole: Which is suitable for on‐demand therapy?

2003 • 16 citations

On-demand proton pump inhibitor therapy in patients with gastro-oesophageal reflux disease

2002 • 13 citations

On-demand therapy for Los Angeles grade A and B reflux esophagitis: esomeprazole versus omeprazole.

2003 • 11 citations

Comparison of the gastroduodenal tolerance of tenoxicam and diclofenac Na

1989 • 11 citations

Time to Relief of Episodic Symptoms of Gastro-Oesophageal Reflux Disease: A Crossover Comparison of Single Doses of the Effervescent and Standard Formulations of Ranitidine

1998 • 10 citations

Long–Term Treatment of Duodenal Ulcer With Cimetidine: Intermittent or Continuous Therapy?

1980 • 10 citations

Long-term treatment of duodenal ulcer with cimetidine. Intermittent or continuous therapy?

1980 • 9 citations

Long term treatment with omeprazole 20 mg three days a week or 10 mg daily in the prevention of duodenal ulcer relapse

1994 • 7 citations

Six Months of Omeprazole 20 mg Daily, 20 mg Every Other Day or 40 mg at Weekends in Duodenal Ulcer Patients: A Multicenter, Prospective, Comparative Study

1995 • 5 citations

Omeprazole or ranitidine for intermittent treatment of GERD?

1999 • 5 citations

Phase I trial of concurrent thoracic radiation and continuous infusion cisplatin and etoposide in stage III non-small cell lung cancer

1999 • 4 citations

Deleted Work

1955 • 0 citations

Cited By (0)

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