Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Human natural killer cells

2008 • 1,768 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor Vaccine

2007 • 636 citations

In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies

2000 • 330 citations

In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies

2000 • 311 citations

Characterization of a messenger RNA polynucleotide vaccine vector.

1995 • 286 citations

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

2008 • 243 citations

Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

2001 • 223 citations

Induction of Tumor-Specific Cytotoxic T Lymphocytes in Cancer Patients by Autologous Tumor RNA-Transfected Dendritic Cells

2002 • 206 citations

Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA

2005 • 192 citations

Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent

2007 • 189 citations

Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

2004 • 143 citations

Immunostimulating capacities of stabilized RNA molecules

2004 • 138 citations

Inability to Immunize Patients with Metastatic Melanoma Using Plasmid DNA Encoding the gp100 Melanoma-Melanocyte Antigen

2003 • 109 citations

Plasmid DNA- and messenger RNA-based anti-cancer vaccination

2007 • 87 citations

Induction of Anti-Tumor Immunity with Epidermal Cells Pulsed with Tumor-Derived RNA or Intradermal Administration of RNA

2000 • 79 citations

Effects of granulocyte‐macrophage colony‐stimulating factor and foreign helper protein as immunologic adjuvants on the T‐cell response to vaccination with tyrosinase peptides

2003 • 76 citations

Selective accumulation of differentiated FOXP3+ CD4+ T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood

2008 • 73 citations

Phase I Trial of Sequential Administration of Recombinant DNA and Adenovirus Expressing L523S Protein in Early Stage Non-Small-Cell Lung Cancer

2006 • 69 citations

Human tumor-specific T lymphocytes: does function matter more than number?

2005 • 53 citations

Production and characterization of amplified tumor-derived cRNA libraries to be used as vaccines against metastatic melanomas

2005 • 35 citations

Human peripheral blood monuclear cells transfected with messenger RNA stimulate antigen-specific cytotoxic T-lymphocytes in vitro

2005 • 23 citations