Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: Different sensitivity to inhibition between systemic sclerosis and control fibroblasts

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

Scleroderma (systemic sclerosis): classification, subsets and pathogenesis

2001 • 3,883 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.

1986 • 645 citations

Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4.

1992 • 498 citations

Cloning and characterization of five overlapping cDNAs specific for the human proα 1(I) collagen chain

1982 • 496 citations

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

1996 • 438 citations

Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins.

1995 • 399 citations

Sequential dermal microvascular and perivascular changes in the development of scleroderma

1992 • 386 citations

Lymphocytes in the skin of patients with progressive systemic sclerosis

1984 • 369 citations

Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

1984 • 336 citations

Interleukin‐1, Interleukin‐2, Interleukin‐4, Interleukin‐6, Tumor Necrosis Factor α, and Interferon‐γ Levels in Sera from Patients With Scleroderma

1992 • 303 citations

Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

1980 • 282 citations

Significant Correlation Between Connective Tissue Growth Factor Gene Expression and Skin Sclerosis in Tissue Sections from Patients with Systemic Sclerosis

1995 • 278 citations

Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation

1995 • 230 citations

Co-localization of transforming growth factor beta 2 with alpha 1(I) procollagen mRNA in tissue sections of patients with systemic sclerosis.

1990 • 219 citations

Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.

1997 • 210 citations

Localization of collagen mRNA in normal and scleroderma skin by in‐situ hybridization

1988 • 207 citations

Transcription and Expression of Transforming Growth Factor Type Beta in the Skin of Progressive Systemic Sclerosis: A Mediator of Fibrosis?

1990 • 177 citations

Identification of Fibroblasts Responsible for Increased Collagen Production in Localized Scleroderma by In Situ Hybridization

1988 • 176 citations

Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts

1986 • 173 citations

Mononuclear Cell-Conditioned Medium Containing Mononuclear Cell Factor (MCF), Homologous With Interleukin 1, Stimulates Collagen and Fibronectin Synthesis by Adherent Rheumatoid Synovial Cells: Effects of Prostaglandin E2 and Indomethacin

1985 • 165 citations

The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor.

1995 • 161 citations

Immunocytochemical Localization and Serologic Detection of Transforming Growth Factor β1

1994 • 158 citations

CD40 Expression by human fibroblasts

1995 • 158 citations

Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents.

1991 • 154 citations

Lymphocyte modulation of fibroblast function in vitro: stimulation and inhibition of collagen production by different effector molecules.

1984 • 139 citations

An alternative splice variant of human IL-4, IL-4 delta 2, inhibits IL-4-stimulated T cell proliferation.

1996 • 128 citations

Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts. Increased proportion of high collagen‐producing cells in systemic sclerosis fibroblasts

1996 • 116 citations

Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines

1993 • 112 citations

Human Th1 cells preferentially induce interleukin (IL)‐1β while Th2 cells induce IL‐1 receptor antagonist production upon cell/cell contact with monocytes

1997 • 90 citations

Interferon‐γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor‐ β in normal human fibroblasts

1990 • 89 citations

Immobilized anti-CD3 antibody activates T cell clones to induce the production of interstitial collagenase, but not tissue inhibitor of metalloproteinases, in monocytic THP-1 cells and dermal fibroblasts.

1995 • 82 citations

Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells.

1990 • 76 citations

Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis

1990 • 76 citations

Direct cell/cell contact with stimulated T lymphocytes induces the expression of cell adhesion molecules and cytokines by human brain microvascular endothelial cells

1996 • 75 citations

Heterogeneity in hormone responses and patterns of collagen synthesis in cloned dermal fibroblasts.

1990 • 73 citations

Interferon‐γ reverses the stimulation of collagen but not fibronectin gene expression by transforming growth factor‐β in normal human fibroblasts

1990 • 71 citations

Alterations in collagen production in mixed mononuclear leukocyte-fibroblast cultures.

1983 • 67 citations

Specific expression of surface interferon‐γ on interferon‐γ producing T cells from mouse and man

1996 • 64 citations

Impaired Regulation of Collagen Pro-∝1(I) mRNA and Change in Pattern of Collagen-Binding Integrins on Scleroderma Fibroblasts

1993 • 60 citations

Immunohistological Demonstration of Transforming Growth Factor-β Isoforms in the Skin of Patients with Systemic Sclerosis

1993 • 59 citations

ICAM-1-dependent fibroblast-lymphocyte adhesion: Discordance between surface expression and function of ICAM-1

1990 • 44 citations

Steady-State mRNA Levels of Collagens I, III, Fibronectin, and Collagenase in Skin Biopsies of Systemic Sclerosis Patients

1991 • 40 citations

Immunologic enhancement of collagen accumulation in progressive systemic sclerosis (PSS)

1981 • 32 citations

JUXTACRINE STIMULATION OF CYTOKINE PRODUCTION IN COCULTURES OF HUMAN DERMAL FIBROBLASTS AND T CELLS

1996 • 29 citations

Scleroderma fibroblast phenotype is modulated by endothelial cell co-culture.

1996 • 21 citations

Selective inhibition of excessive scleroderma fibroblast collagen production by lymphokines from normal human mononuclear cells

1985 • 19 citations

Mononuclear cell-fibroblast interactions in scleroderma

1988 • 16 citations

Transcriptional activation of fibroblast collagenase gene expression by a novel lymphokine, leukoregulin.

1992 • 15 citations

T lymphocyte–synovial fibroblast interactions induced by mycobacterial proteins in rheumatoid arthritis

1991 • 13 citations

Identification of a Human Dermal Macrophage Population Responsible for Constitutive Restraint of Primary Dermal Fibroblast Proliferation

1996 • 11 citations