Where do we stand on the autoimmunity hypothesis of Chagas disease?

Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen.

1995 • 226 citations

Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.

1987 • 224 citations

Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.

1996 • 213 citations

Chagasic Cardiopathy

1974 • 204 citations

Chagas’ Disease and the Autoimmunity Hypothesis

1999 • 178 citations

Chagas disease: a role for autoimmunity?

2003 • 168 citations

Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi.

1992 • 162 citations

“Autoimmune rejection” of neonatal heart transplants in experimental Chagas disease is a parasite-specific response to infected host tissue

1997 • 148 citations

Autoimmunity in Chaga's Disease

1986 • 129 citations

Autoimmunity in chagas disease cardiomyopathy: Fulfilling the criteria at last?

1996 • 128 citations

Pathogenesis of Chagas heart disease: role of autoimmunity

2002 • 118 citations

Circulating antibodies to peripheral nerve in American trypanosomiasis (Chagas' disease).

1979 • 107 citations

Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease.

1990 • 103 citations

Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implications

1997 • 102 citations

Antibodies to ribosomal P proteins ofTrypanosoma cruziin Chagas disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in lupus

1997 • 95 citations

Sera From Chronic Chagasic Patients With Complex Cardiac Arrhythmias Depress Electrogenesis and Conduction in Isolated Rabbit Hearts

1997 • 95 citations

Experimental Chronic Chagas' Disease Myocarditis is an Autoimmune Disease Preventable by Induction of Immunological Tolerance to Myocardial Antigens

2002 • 79 citations

The significance of autoimmunity in the pathogenesis of chagas heart disease

2003 • 78 citations

Dominant T- and B-cell epitopes in an autoantigen linked to Chagas’ disease

2001 • 70 citations

Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked byTrypanosoma cruziantigens

1998 • 65 citations

Antibodies against the carboxyl‐terminal end of theTrypanosoma cruziribosomal P proteins are pathogenic

2001 • 59 citations

Is there autoimmunity in Chagas disease?

1985 • 57 citations

Views on the autoimmunity hypothesis for Chagas disease pathogenesis

2003 • 56 citations

A Cardiac Myosin-Specific Autoimmune Response Is Induced by Immunization withTrypanosoma cruziProteins

2004 • 51 citations

Heart-infiltrating and Peripheral T Cells in the Pathogenesis of Human Chagas' Disease Cardiomyopathy

2001 • 50 citations

Heterophil nature of EVI antibody in Trypanosoma cruzi infection

1983 • 49 citations

A histopathological analysis of the course of myocarditis in C3H/He mice infected with Trypanosoma cruzi clone Sylvio-X10/4

1986 • 45 citations

Anti-Myosin Humoral Immune Response Following Cardiac Injury

1989 • 43 citations

Myosin Autoimmunity Is Not Essential for Cardiac Inflammation in Acute Chagas’ Disease

2003 • 42 citations

Antibodies to an Epitope from the Cha Human Autoantigen Are Markers of Chagas' Disease

2001 • 39 citations

Relationship between the degree of injury at operation and the change in antimyosin antibody titer in the postpericardiotomy syndrome

1994 • 31 citations

Structural and functional complexity of the humoral response against theTrypanosoma cruziribosomal P2βprotein in patients with chronic Chagas’ heart disease

2004 • 27 citations

Members of the SAPA/trans-sialidase protein family have identical N-terminal sequences and a putative signal peptide

1993 • 21 citations

Human Chagasic Disease is Not Associated With an Antiheart Humoral Response

1997 • 15 citations

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