Paired Helical Filaments (PHF): Update 1988

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

1985 • 1,025 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

1987 • 606 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants

1982 • 541 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Alzheimer's disease : senile dementia and related disorders

1978 • 369 citations

Aberrant neurofilament phosphorylation in Alzheimer disease.

1985 • 339 citations

Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments

1986 • 310 citations

Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia

1979 • 279 citations

Senile Dementia of the Alzheimer Type Without Neocortical Neurofibrillary Tangles

1987 • 269 citations

ALZHEIMERʼS DISEASE

1953 • 267 citations

Aging of the brain and dementia

1980 • 259 citations

Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

1984 • 227 citations

Alzheimer paired helical filaments: Bulk isolation, solubility, and protein composition

1984 • 227 citations

Mise en évidence immunologique de la protéine tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d'Alzheimer

1985 • 163 citations

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1988 • 125 citations

Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

1984 • 106 citations

Alzheimer paired helical filaments: Immunochemical identification of polypeptides

1984 • 104 citations

Neurofibrillary Changes in Human Brain

1983 • 103 citations

Selective neuronal death.

1987 • 80 citations

Discovery and Partial Characterization of Primate Motor‐System Toxins

2007 • 76 citations

Alzheimer paired helical filaments: Identification of polypeptides with monoclonal antibodies

1985 • 40 citations

Neurofibrillary tangles in human upper cervical ganglia

1987 • 30 citations

Selective Neuronal Death (Ciba Foundation Symposium 126)

1987 • 21 citations

Young adult-form of dementia with neurofibrillary changes and lewy bodies

1987 • 18 citations

40 ISOLATION AND PROPERTIES OF ALZHEIMER NEUROFIBRILLARY TANGLES

1981 • 12 citations

NEUROFIBRILLARY CHANGES IN ADVANCED HYDROCEPHALUS. A CLINICOPATHOLOGICAL STUDY

1987 • 11 citations

GENE DOSE EFFECT ON EARLY FORMATION OF NEURITIC PLAQUES IN DOWN SYNDROME (DS)

1987 • 4 citations

PAIRED HELICAL FILAMENT (PHF) IMMUNOREACTIVITY IN CSF

1988 • 1 citations