Recent studies on dendrotoxins and potassium ion channels

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

1989 • 765 citations

Temporal integration by a slowly inactivating K+ current in hippocampal neurons

1988 • 554 citations

Heteromultimeric channels formed by rat brain potassium-channel proteins

1990 • 409 citations

Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain

1990 • 317 citations

A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression.

1993 • 265 citations

K+ channels of stomatal guard cells. Characteristics of the inward rectifier and its control by pH.

1992 • 236 citations

Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.

1986 • 221 citations

An emerging pharmacology of peptide toxins targeted against potassium channels

1988 • 218 citations

Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I.

1988 • 201 citations

Characterization of a Shaw-related potassium channel family in rat brain.

1992 • 199 citations

4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current

1986 • 175 citations

Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps

1980 • 160 citations

Two pharmacologically and kinetically distinct transient potassium currents in cultured embryonic mouse hippocampal neurons

1992 • 150 citations

Antibodies specific for distinct Kv subunits unveil a heterooligomeric basis for subtypes of .alpha.-dendrotoxin-sensitive potassium channels in bovine brain

1994 • 147 citations

Neurotoxins and Their Pharmacological Implications

1988 • 147 citations

Dendrotoxins: Snake toxins that block potassium channels and facilitate neurotransmitter release

1985 • 140 citations

PROTEASE INHIBITOR HOMOLOGUES FROM MAMBA VENOMS: FACILITATION OF ACETYLCHOLINE RELEASE AND INTERACTIONS WITH PREJUNCTIONAL BLOCKING TOXINS

1982 • 140 citations

Oligomeric properties of .alpha.-dendrotoxin-sensitive potassium ion channels purified from bovine brain

1992 • 132 citations

The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals.

1987 • 127 citations

Peptide Toxins and Potassium Channels

1990 • 126 citations

Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP

1993 • 125 citations

Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins

1987 • 119 citations

Dendrotoxin acceptor from bovine synaptic plasma membranes. Binding properties, purification and subunit composition of a putative constituent of certain voltage-activated K+ channels

1989 • 116 citations

Dendrotoxin: a selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones

1986 • 104 citations

Crystal structure of α-dendrotoxin from the green mamba venom and its comparison with the structure of bovine pancreatic trypsin inhibitor

1992 • 101 citations

Toxin I from the snakeDendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fiber

1986 • 99 citations

Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels.

1989 • 97 citations

Properties of voltage-gated K+ currents expressed inXenopus oocytes by mKv1.1, mKv1.2 and their heteromultimers as revealed by mutagenesis of the dendrotoxin-binding site in mKv1.1

1994 • 95 citations

Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes.

1988 • 94 citations

Dendrotoxin-binding brain membrane protein displays a potassium channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations

1989 • 94 citations

Identification of amino acid residues involved in dendrotoxin block of rat voltage-dependent potassium channels.

1991 • 93 citations

Proteinase inhibitors and dendrotoxins

1985 • 92 citations

Single voltage‐dependent potassium channels in rat peripheral nerve membrane.

1993 • 92 citations

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

1984 • 88 citations

Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity

1988 • 83 citations

Voltage-gated potassium currents in acutely dissociated rat cortical neurons

1993 • 79 citations

Peptide toxins and potassium channels

1990 • 78 citations

Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin

1985 • 75 citations

Nuclear Magnetic Resonance Solution Structure of Dendrotoxin K from the Venom of Dendroaspis polylepis polylepis

1993 • 74 citations

Dendrotoxin-sensitive K+ channels in dorsal root ganglion cells

1988 • 72 citations

Both N- and C-terminal regions contribute to the assembly and functional expression of homo- and heteromultimeric voltage-gated K+ channels

1994 • 71 citations

Protease inhibitors as snake venom toxins.

1973 • 70 citations

A K+ channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and voltage‐clamp experiments.

1990 • 68 citations

Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channel Kv1.2

1992 • 65 citations

Functional characterization of RK5, a voltage‐gated K⁺ channel cloned from the rat cardiovascular system

1991 • 65 citations

The α-Dendrotoxin Footprint on a Mammalian Potassium Channel

1995 • 64 citations

Snake Venoms. The Amino Acid Sequences of two Proteinase Inhibitor Homologues fromDendroaspis angusticepsVenom

1980 • 60 citations

Production of seizures and brain damage in rats by α-dendrotoxin, a selective K+ channel blocker

1992 • 60 citations

Solubilization and physical characterization of acceptors for dendrotoxin and .beta.-bungarotoxin from synaptic membranes of rat brain

1988 • 57 citations

K+ channel sub-types in rat brain: Characteristic locations revealed using β-bungarotoxin, α- and δ-dendrotoxins

1991 • 56 citations

Proteinase inhibitor homologues as potassium channel blockers

1994 • 55 citations

Analogies and differences in the mode of action and properties of binding sites (localization and mutual interactions) of two K+ channel toxins, MCD peptide and dendrotoxin I

1989 • 52 citations

Distribution in the rat central nervous system of acceptor sub-types for dendrotoxin, a K+ channel probe

1989 • 49 citations

EFFECTS OF THE VENOM OF THE GREEN MAMBA, Dendroaspis angusticeps ON SKELETAL MUSCLE AND NEUROMUSCULAR TRANSMISSION

1979 • 45 citations

Immunological evidence for a relationship between the dendrotoxin‐binding protein and the mammalian homologue of the Drosophila Shaker K⁺ channel

1989 • 43 citations

Two types of fast K+ channels in rat myelinated nerve fibres and their sensitivity to dendrotoxin

1991 • 43 citations

Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kvl.2) K+ channel complementary DNA

1992 • 43 citations

Two types of 4‐aminopyridine‐sensitive potassium current in rabbit Schwann cells.

1993 • 42 citations

Genetic strategies in epilepsy research

1992 • 40 citations

Cloning and functional expression of dendrotoxin K from black mamba, a potassium channel blocker

1993 • 39 citations

Blockade by dendrotoxin homologues of voltage‐dependent K⁺ currents in cultured sensory neurones from neonatal rats

1994 • 39 citations

Properties of voltage-gated potassium currents of microglia differentiated with granulocyte/macrophage colony-stimulating factor

1995 • 37 citations

Electrophysiological characterization of a new member of the RCK family of rat brain K⁺ channels

1991 • 36 citations

On the site by which α‐dendrotoxin binds to voltage‐dependent potassium channels: Site‐directed mutagenesis reveals that the lysine triplet 28–30 is not essential for binding

1994 • 36 citations

Sequence‐specific ¹H‐NMR assignment and secondary structure of black mamba dendrotoxin I, a highly selective blocker of voltage‐gated potassium channels

1993 • 35 citations

Protection against dendrotoxin-induced clonic seizures in mice by anticonvulsant drugs

1992 • 35 citations

Limbic epilepsy induced in the rat by dendrotoxin, a polypeptide isolated from the green mamba (Dendroaspis angusticeps) venom

1987 • 35 citations

Pharmacology of a cloned potassium channel from mouse brain (MK‐1) expressed in CHO cells: effects of blockers and an ‘nactivation peptide’

1993 • 31 citations

Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat

1991 • 31 citations

Facilitation of transmitter release by neurotoxins from snake venoms.

1984 • 28 citations

Characterisation of Binding Sites for δ‐Dendrotoxin in Guinea‐Pig Synaptosomes: Relationship to Acceptors for the K⁺‐Channel Probe α‐Dendrotoxin

1990 • 25 citations

Identification of RBK1 potassium channels in C6 astrocytoma cells

1992 • 23 citations

Dendrotoxin blocks accommodation in frog myelinated axons

1989 • 20 citations

K+ channel involvement in induction of synaptic enhancement by mast cell degranulating (MCD) peptide

1992 • 18 citations

Rat brain dendrotoxin receptors associated with voltage-gated potassium channels: dendrotoxin binding and receptor solubilization.

1989 • 17 citations

Behavioral and neurochemical effects of intraperitoneally injected dendrotoxin

1988 • 17 citations

Structural features important for the biological activity of the potassium channel blocking dendrotoxins

1993 • 17 citations

Genetic Strategies in Epilepsy Research

1991 • 17 citations

Monoclonal and polyclonal antibodies against dendrotoxin: Their effects on its convulsive activity and interaction with neuronal acceptors

1986 • 15 citations

The effects of protease inhibitor homologues from mamba snake venoms on autonomic neurotransmission

1985 • 13 citations

Selective block by ?-dendrotoxin of the K+ inward rectifier at the Vicia guard cell plasma membrane

1994 • 13 citations

Expression of a genomic clone encoding a brain potassium channel in mammalian cells using lipofection

1992 • 12 citations

Cloning and expression of mamba toxins

1995 • 12 citations

Potassium channels and epilepsy: evidence that the epileptogenic toxin, dendrotoxin, binds to potassium channel proteins.

1991 • 11 citations

Protease Inhibitor Homologues of Dendrotoxin do not Bind to Dendrotoxin Acceptors on Synaptosomal Membranes or Facilitate Neuromuscular Transmission

1992 • 9 citations

Inhibition of a K+ current by beta-dendrotoxin in primary and subcultured vascular smooth muscle cells.

1994 • 9 citations

Action of α-dendrotoxin on K+ currents in nerve terminal regions of axons in rat olfactory cortex

1993 • 5 citations

Expression and pharmacological activity of recombinant dendrotoxin

1993 • 1 citations

Deleted Work

1955 • 0 citations