The role of systemic chemotherapy in the treatment of brain metastases from small-cell lung cancer

A Randomized Trial of Surgery in the Treatment of Single Metastases to the Brain

1990 • 3,068 citations

Prophylactic Cranial Irradiation for Patients with Small-Cell Lung Cancer in Complete Remission

1999 • 1,607 citations

A phase II study

2000 • 757 citations

Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group.

1993 • 716 citations

Prophylactic Cranial Irradiation for Patients With Small-Cell Lung Cancer in Complete Remission

1995 • 513 citations

CNS metastases in small cell bronchogenic carcinoma.Increasing frequency and changing pattern with lengthening survival

1979 • 478 citations

Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group and New Drug Development Office, and the Lung Cancer Cooperative Group.

1997 • 474 citations

Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma.

1983 • 394 citations

Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: Results of a multicentre randomised trial

1997 • 363 citations

Evaluation of cognitive function in patients with limited small cell lung cancer prior to and shortly following prophylactic cranial irradiation

1995 • 212 citations

A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation

1980 • 210 citations

Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.

1982 • 184 citations

Cerebrospinal fluid pharmacokinetics and penetration of continuous infusion topotecan in children with central nervous system tumors

1995 • 141 citations

Systemic chemotherapy of brain metastases from small-cell lung cancer: a review.

1992 • 131 citations

Central nervous system metastases in small cell bronchogenic carcinoma.

1978 • 126 citations

Patients with limited-stage small-cell lung cancer treated with concurrent twice-daily chest radiotherapy and etoposide/cisplatin followed by cyclophosphamide, doxorubicin, and vincristine.

1996 • 124 citations

Primary chemotherapy of brain metastasis in small-cell lung cancer.

1989 • 112 citations

The response of cerebral metastases in small cell lung cancer to systemic chemotherapy

1990 • 104 citations

Chemotherapy for brain metastases of lung cancer: A review

1999 • 96 citations

Plasma and cerebrospinal fluid pharmacokinetic study of topotecan in nonhuman primates.

1993 • 96 citations

Brain-only metastases of small cell lung cancer; efficacy of whole brain radiotherapy. An EORTC phase II study

1998 • 95 citations

Comparison of symptomatic and prophylactic irradiation of brain metastases from oat cell carcinoma of the lung

1981 • 86 citations

Intracranial metastases in small cell carcinoma of the lung prognostic aspects

1983 • 84 citations

Penetration of VP 16-213 into cerebrospinal fluid after high-dose intravenous administration.

1984 • 77 citations

Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumors.

1997 • 75 citations

Results of therapeutic cranial irradiation in small cell lung cancer

1988 • 70 citations

The Effect of Steroids on the Extravascular Distribution of Radiographic Contrast Material and Technetium Pertechnetate in Brain Tumors as Determined by Computed Tomography

1976 • 68 citations

Favorable Prognosis of Brain Metastases in Small Cell Lung Cancer

1987 • 68 citations

Teniposide for brain metastases of small-cell lung cancer: a phase II study. European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.

1995 • 67 citations

Lung Cancer: Basic and Clinical Aspects

1986 • 66 citations

Results of whole-brain irradiation for metastases from small cell carcinoma of the lung.

1980 • 64 citations

Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primates

1998 • 61 citations

Carboplatin as second line treatment for recurrent or progressive brain metastases from small cell lung cancer

1993 • 58 citations

Morbidity of cranial relapse in small cell lung cancer and the impact of radiation therapy

1987 • 56 citations

Brain metastases from small cell lung cancer treated with combination chemotherapy

1988 • 55 citations

A pharmacokinetic model of topotecan clearance from plasma and cerebrospinal fluid.

1994 • 54 citations

Toxicology and pharmacology of the nitrosoureas.

1973 • 49 citations

High dose etoposide for brain metastases of small cell lung cancer. A phase II study

1989 • 47 citations

Prospective evaluation of the effect on initial brain metastases from small cell lung cancer of platinum-etoposide based induction chemotherapy followed by an alternating multidrug regimen

1993 • 42 citations

Topotecan - A New Treatment Option in the Therapy of Brain Metastases of Lung Cancer

1999 • 34 citations

Primary chemotherapy of brain metastasis in small-cell lung cancer

1990 • 31 citations

Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung

1988 • 26 citations

Treatment of brain metastases of lung cancer with high doses of etoposide (VP16–213). Cooperative study from the groupe français pneumo-cancérologie

1988 • 24 citations

Chemotherapy for central nervous system metastases from small cell lung cancer. A review

1989 • 17 citations

Topotecan (Hycamtin™) in small cell lung cancer (SCLC) after failure of first line therapy: Multicentre phase II study

1997 • 16 citations

Carboplatin in association with etoposide and either adriamycin or epirubicin for untreated small cell lung cancer: A dose escalation study of carboplatin

1989 • 14 citations

A Molded Acrylic Applicator for Guiding the Peroral X-Ray Beam

1976 • 4 citations