Progress and pitfalls: bipolar molecular linkage studies

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

1996 • 2,667 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

BRCA1 Mutations in Primary Breast and Ovarian Carcinomas

1994 • 1,205 citations

G _olf : an Olfactory Neuron Specific-G Protein Involved in Odorant Signal Transduction

1989 • 863 citations

Bipolar affective disorders linked to DNA markers on chromosome 11

1987 • 826 citations

Manic Depressive Illness.

1970 • 720 citations

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish

1989 • 443 citations

Genetic linkage between X-chromosome markers and bipolar affective illness

1987 • 420 citations

Continuity and Discontinuity of Affective Disorders and Schizophrenia

1993 • 379 citations

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

1994 • 378 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 355 citations

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect.

1995 • 347 citations

A Controlled Family Study of Chronic Psychoses

1988 • 347 citations

Birth-Cohort Trends in Rates of Major Depressive Disorder Among Relatives of Patients With Affective Disorder

1985 • 324 citations

Trinucleotide Repeats in Neurogenetic Disorders

1996 • 323 citations

A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3

1994 • 320 citations

A locus for bipolar affective disorder on chromosome 4p

1996 • 272 citations

Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23

1996 • 260 citations

THE PROBLEM OF ANTICIPATION IN PEDIGREES OF DYSTROPHIA MYOTONICA

1947 • 259 citations

Molecular genetic evidence for heterogeneity in manic depression

1987 • 252 citations

Anticipation in bipolar affective disorder.

1993 • 230 citations

POLYMORPHIC DNA MARKER ON X CHROMOSOME AND MANIC DEPRESSION

1987 • 227 citations

Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling considerations

1996 • 225 citations

Linkage analysis of "necessary" disease loci versus "susceptibility" loci.

1993 • 218 citations

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 1, 6, 8, 10, and 12

1997 • 218 citations

Patterns of maternal transmission in bipolar affective disorder.

1995 • 216 citations

A Comprehensive Genetic Linkage Map of the Human Genome

1992 • 213 citations

Birth-Cohort Changes in Manic and Depressive Disorders in Relatives of Bipolar and Schizoaffective Patients

1987 • 201 citations

A complete genome screen for genes predisposing to severe bipolar disorder in two Costa Rican pedigrees

1996 • 175 citations

A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish

1996 • 173 citations

Chromosome 18 DNA markers and manic-depressive illness : evidence for a susceptibility gene

1994 • 169 citations

Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illnesses.

1974 • 166 citations

Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: Chromosomes 3, 5, 15, 16, 17, and 22

1997 • 165 citations

Age, period and cohort effects on the risk of major depression: results from five United States communities

1989 • 164 citations

Diminished support for linkage between manic depressive illness and X–chromosome markers in three Israeli pedigrees

1993 • 162 citations

The Expanding World of Trinucleotide Repeats

1996 • 157 citations

Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.

1995 • 142 citations

Detection of expanded CAG repeats in Bipolar Affective Disorder using the repeat expansion detection (RED) method

1995 • 138 citations

Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees

1996 • 138 citations

Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 4, 7, 9, 18, 19, 20, and 21q

1997 • 133 citations

Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder

1996 • 131 citations

Linkage between Glucose-6-Phosphate Dehydrogenase Deficiency and Manic-Depressive Psychosis

1980 • 129 citations

Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q.

1996 • 124 citations

A Linkage Study of Bipolar Illness

1997 • 118 citations

The Iowa 500: affective disorder in relatives of manic and depressed patients

1982 • 107 citations

X-Chromosome Markers and Manic-Depressive Illness

1990 • 105 citations

Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11, 13, 14, and X

1997 • 104 citations

Color Blindness Linkage to Bipolar Manic-Depressive Illness

1979 • 98 citations

Two-Locus Admixture Linkage Analysis of Bipolar and Unipolar Affective Disorder Supports the Presence of Susceptibility Loci on Chromosomes 11p15 and 21q22

1997 • 93 citations

A Family Study of Manic-Depressive (Bipolar I) Disease

1995 • 93 citations

Anticipation in Swedish families with bipolar affective disorder.

1994 • 93 citations

Birth cohort trends in major depression: increasing rates and earlier onset in New Zealand

1990 • 90 citations

A Family Interview Study of Male Manic Depressives

1974 • 88 citations

Linkage Between an X-Chromosome Marker (Deutan Color Blindness) and Bipolar Affective Illness

1977 • 87 citations

A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

1993 • 87 citations

Linkage analysis of manic depression in an Irish family using H-ras 1 and INS DNA markers.

1988 • 79 citations

Two-locus models of disease: comparison of likelihood and nonparametric linkage methods.

1993 • 75 citations

Linkage between X‐chromosome markers and manic‐depressive illness

1984 • 70 citations

Depressive illness : prediction of course and outcome

1988 • 63 citations

A Critical Appraisal of X-Linked Bipolar Illness

1992 • 61 citations

Close linkage of bipolar disorder to chromosome 11 markers is excluded in two large Australian pedigrees

1991 • 61 citations

Inositol monophosphatase, the putative therapeutic target for lithium

1996 • 58 citations

Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression

1996 • 57 citations

A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder

1997 • 56 citations

Statistical pitfalls in detecting age-of-onset anticipation

1995 • 55 citations

Absence of linkage between chromosome 11p15 markers and manic- depressive illness in a Belgian pedigree

1991 • 53 citations

RFLP alleles at the tyrosine hydroxylase locus: No association found to affective disorders

1990 • 48 citations

Human G(olf) alpha: complementary deoxyribonucleic acid structure and expression in pancreatic islets and other tissues outside the olfactory neuroepithelium and central nervous system.

1993 • 45 citations

Genetic linkage mapping for a susceptibility locus to bipolar illness: Chromosomes 2,3,4,7,9,10p,11p,22, and Xpter

1994 • 45 citations

Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.

1995 • 44 citations

Age-at-interview bias in anticipation studies

1996 • 43 citations

Tyrosine hydroxylase polymorphisms and bipolar affective disorder

1991 • 41 citations

Manic depressive illness is linked to factor IX in a French pedigree.

1992 • 39 citations

Lack of association between bipolar affective disorder and tyrosine hydroxylase DNA marker

1993 • 36 citations

Searching for susceptibility genes in schizophrenia by genetic linkage analysis.

1996 • 35 citations

Association and haplotype analysis at the tyrosine hydroxylase locus in a combined German-British sample of manic depressive patients and controls

1994 • 35 citations

A systematic search for a bipolar predisposing locus on chromosome 5.

1992 • 25 citations

Expanded CAG/CTG repeats in bipolar disorder: No correlation with phenotypic measures of illness severity

1997 • 22 citations

Cosegregation of Christmas Disease and Major Affective Disorder in a Pedigree

1992 • 20 citations

Genome-wide microsatellite marker linkage study of bipolar affective disorders in a very large pedigree derived from a homogeneous population in Quebec points to susceptibility locus on chromosome 12

1996 • 19 citations

Linkage Analyses in Type I Diabetes mellitus Using CASPAR, a Software and Statistical Program for Conditional Analysis of Polygenic Diseases

1997 • 18 citations

Linkage Analysis of Manic Depression (Bipolar Affective Disorder) in Icelandic and British Kindreds using Markers on the Short Arm of Chromosome 18

1997 • 17 citations

Lack of evidence for a major locus for bipolar disorder in the pericentromeric region of chromosome 18 in irish pedigrees

1997 • 16 citations

Personality as a Mediating Variable in the Pathogenesis of Mood Disorders: Implications for Theory, Research, and Prevention

1988 • 13 citations

Linkage studies of bipolar disorder to chromosome 18 markers

1996 • 11 citations

18P — A susceptibility locus for affective and schizophrenic disorder?

1996 • 11 citations

Anticipation in unipolar affective disorder

1995 • 10 citations

Report of the Fourth International Workshop on Human Chromosome 18 Mapping 1996

1996 • 9 citations

Genetic linkage studies of bipolar affective disorder.

1990 • 7 citations

Association and linkage studies of affective disorders

1991 • 7 citations

Linkage study of bipolar affective disorder with chromosome 4p markers

1996 • 3 citations