Study of intestinal cell differentiation with monoclonal antibodies to intestinal cell surface components

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Physiology of the Gastrointestinal Tract

2006 • 4,704 citations

High resolution two-dimensional electrophoresis of basic as well as acidic proteins

1977 • 3,556 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

1964 • 2,108 citations

Antibodies to major histocompatibility antigens produced by hybrid cell lines

1977 • 1,727 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

1974 • 1,697 citations

A modified procedure for the rapid preparation of efficiently transporting vesicles from small intestinal brush border membranes. Their use in investigating some properties of d-glucose and choline transport systems

1978 • 1,145 citations

Intestinal Epithelial Cell Surface Membrane Glycoprotein Synthesis

1973 • 1,111 citations

Glucose Transport in Isolated Brush Border Membrane from Rat Small Intestine

1973 • 841 citations

Two-dimensional gel electrophoresis of membrane proteins

1976 • 702 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine II. Mucous cells

1974 • 618 citations

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine I. Columnar cell

1974 • 565 citations

Rat intestinal microvillus membranes. Purification and biochemical characterization

1968 • 452 citations

Topology of microvillar membrance hydrolases of kidney and intestine.

1982 • 437 citations

A one-step ultramicro method for the assay of intestinal disaccharidases

1966 • 420 citations

Cell proliferation studies in the intestinal epithelium of the rat I. Determination of the kinetic parameters

1965 • 362 citations

Transformation by Rous sarcoma virus: effects of src gene expression on the synthesis and phosphorylation of cellular polypeptides.

1979 • 293 citations

γ‐Glutamyltransferase in kidney brush border membranes

1972 • 292 citations

QUANTITATIVE DETERMINATION OF ENZYMES IN DIFFERENT PARTS OF THE VILLI AND CRYPTS OF RAT SMALL INTESTINE COMPARISON OF ALKALINE PHOSPHATASE, DISACCHARIDASES AND DIPEPTIDASES

1967 • 230 citations

Intestinal Invertase: Precocious Development of Activity after Injection of Hydrocortisone

1964 • 223 citations

Functional morphology of the mucosa of the small intestine

1994 • 202 citations

Cell proliferation studies in the intestinal epithelium of the rat II. Theoretical aspects

1965 • 154 citations

THERMOPHILIC AMINOPEPTIDASES FROM BACILLUS STEAROTHERMOPHILUS. I. ISOLATION, SPECIFICITY, AND GENERAL PROPERTIES OF THE THERMOSTABLE AMINOPEPTIDASE I *

1969 • 135 citations

Purification of microvilli and an analysis of the protein components of the microfilament core bundle

1978 • 133 citations

The preparation of lactase and glucoamylase of rat small intestine

1972 • 125 citations

Immunochemical studies of intestinal disaccharidases during normal and precocious development.

1965 • 107 citations

Purification and Characterisation of Amphiphilic Lactase/Phlorizin Hydrolase from Human Small Intestine

1981 • 107 citations

Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants.

1982 • 104 citations

Monoclonal antibodies to sucrase/isomaltase: probes for the study of postnatal development and biogenesis of the intestinal microvillus membrane.

1980 • 103 citations

The 46,000-dalton tyrosine protein kinase substrate is widespread, whereas the 36,000-dalton substrate is only expressed at high levels in certain rodent tissues.

1984 • 103 citations

Intestinal enzymes activities in isolated villus and crypt cells during postnatal development of the rat

1977 • 102 citations

Synthesis of plasmalemmal glycoproteins in intestinal epithelial cells. Separation of Golgi membranes from villus and crypt cell surface membranes; glycosyltransferase activity of surface membrane

1978 • 101 citations

Development of the functions of the small intestine in mammals and man

1969 • 100 citations

The Relation of Size to the Relative Rates of Degradation of Intestinal Brush Border Proteins

1972 • 94 citations

Biosynthesis of intestinal microvillar proteins. Evidence for an intracellular sorting taking place in, or shortly after, exit from the Golgi complex

1985 • 89 citations

Biosynthesis of intestinal microvillar proteins. Pulse-chase labelling studies on aminopeptidase N and sucrase-isomaltase

1982 • 82 citations

Synthesis of membrane glycoproteins in rat small-intestinal villus cells. Redistribution of <scp>l</scp>-[1,5,6-3H]-fucose-labelled membrane glycoproteins among Golgi, lateral basal and microvillus membranes in vivo

1979 • 78 citations

The relation between cell proliferation, differentiation and ultrastructural development in rat intestinal epithelium

1976 • 70 citations

Changes in the distribution of the 34-kdalton tyrosine kinase substrate during differentiation and maturation of chicken tissues.

1984 • 69 citations

Incomplete intracellular forms of intestinal surface membrane sucrase-isomaltase.

1979 • 66 citations

Transplantation of Fetal Intestine

1974 • 65 citations

Purification of rat intestinal maltase/glucoamylase and its anomalous dissociation either by heat or by low pH

1978 • 63 citations

Dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine

1978 • 61 citations

Developmental pattern of rat intestinal brush-border enzymic proteins along the villus–crypt axis

1979 • 57 citations

Evidence for biosynthesis of lactase-phlorizin hydrolase as a single-chain high-molecular weight precursor

1984 • 57 citations

Removal of protein interference in the Fiske-SubbaRow method by sodium dodecyl sulfate

1975 • 51 citations

Effect of ionic strength and calcium ions on the activation of trypsinogen by enterokinase

1973 • 50 citations

Crypt cell development in newborn rat small intestine.

1985 • 50 citations

Radioautographic visualization of differences in the pattern of [3H]uridine and [3H]orotic acid incorporation into the RNA of migrating columnar cells in the rat small intestine.

1984 • 36 citations

Brush Border Membranes

1983 • 35 citations

Demonstration of a difference in expression of maximal lactase and sucrase activity along the villus in the adult rat jejunum

1980 • 34 citations

Mitomycin C treated cells as feeders

1971 • 34 citations

Pre- and postnatal development of differentiated functions in rat intestinal epithelial cells

1985 • 33 citations

Possible precursors of aminopeptidase and alkaline phosphatase in the proximal tubules of kidney and the crypts of small intestine of mice

1974 • 33 citations

Effect of dietary sucrose on synthesis and degradation of intestinal sucrase

1984 • 32 citations

Surface-membrane biogenesis in rat intestinal epithelial cells at different stages of maturation

1980 • 32 citations

Catalytically inactive sucrase antigen of rabbit small intestine: the enzyme precursor.

1975 • 27 citations

Apical distribution of fatty acid esterification capacity along the villus-crypt unit of rat jejunum

1980 • 21 citations

Changes in the synthesis of ribosomal ribonucleic acid and of poly(A)-containing ribonucleic acid during the differentiation of intestinal epithelial cells in the rat and in the chick

1980 • 20 citations

Factors involved in the differentiation of the epithelial cells in the adult rat small intestine

1976 • 14 citations

Preparative Scale Isolation of Basal-Lateral Plasma Membranes from Rat Intestinal Epithelial Cells

1978 • 14 citations

Use of Monoclonal Antibodies in the Study of Intestinal Structure and Function

1983 • 13 citations

A band of alkaline phosphatase activity in the crypts of mouse duodenal epithelium.

1981 • 12 citations

Enzyme activity in partly dissociated fragments of rat intestinal maltase/glucoamylase

1979 • 11 citations

Some characteristics of early appearing isomaltase in intestinal mucosa of suckling rat.

1979 • 8 citations

Changes of immunoreactive sucrase-isomaltase complex in rat small intestine during postnatal development and maturation along the villus-crypt axis.

1980 • 6 citations