FK506 and cyclosporin A inhibit growth factor-stimulated human keratinocyte proliferation by blocking cells in the G0G1 phases of the cell cycle

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

1987 • 1,209 citations

Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes.

1989 • 844 citations

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1990 • 736 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Cyclosporine Improves Psoriasis in a Double-blind Study

1986 • 535 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.

1991 • 407 citations

Changes in Keratinocyte Maturation During Wound Healing

1987 • 375 citations

Altered [125I] Epidermal Growth Factor Binding and Receptor Distribution in Psoriasis

1986 • 289 citations

Clearance of psoriasis with low dose cyclosporin.

1986 • 233 citations

Detection of transforming growth factor alpha in normal, malignant, and hyperproliferative human keratinocytes.

1988 • 227 citations

Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques.

1986 • 196 citations

Upper Keratinocytes of Psoriatic Skin Lesions Express High Levels of NAP-1/IL-8 mRNA In Situ

1991 • 175 citations

Epidermal Keratiocytes Express the Adhesion Molecule Intercellular Adhesion Molecule-1 in Inflammatory Dermatoses.

1989 • 170 citations

Tacrolimus (FK 506)—A New Therapeutic Agent for Severe Recalcitrant Psoriasis

1992 • 161 citations

Cytokines in skin lesions of psoriasis

1990 • 140 citations

Increased expression of epidermal IL-8 receptor in psoriasis. Down-regulation by FK-506 in vitro.

1993 • 123 citations

Control of growth and differentiation in vitro of human keratinocytes cultured in serum-free medium

1987 • 119 citations

Levels of Cyclosporin in Epidermis of Treated Psoriasis Patients Differentially Inhibit Growth of Keratinocytes Cultured in Serum Free Versus Serum Containing Media

1988 • 116 citations

Cyclosporine improves psoriasis in a double-blind study

1986 • 112 citations

The Effect of Cyclosporin A on Epidermal Cells. II. Cyclosporin A Inhibits Proliferation of Normal and Transformed Keratinocytes

1988 • 100 citations

Differential effects of epidermal growth factor, transforming growth factor, and insulin on DNA and protein synthesis and morphology in serum-free cultures of AKR-2B cells.

1984 • 93 citations

Interleukin 6 and expression of its receptor on epidermal keratinocytes

1990 • 82 citations

HLA-DR antigen expression on keratinocytes in highly inflamed parts of psoriatic lesions

1987 • 64 citations

Additive and synergistic antiproliferative effects of cyclosporin A and gamma interferon on cultured human keratinocytes.

1988 • 60 citations

Human keratinocyte culture. Identification and staging of epidermal cell subpopulations.

1986 • 56 citations

Cyclosporin A inhibits keratinocyte cytokine gene expression

1994 • 52 citations

Differential Inhibition of Cutaneous T-Cell-Mediated Reactions and Epidermal Cell Proliferation by Cyclosporin A, FK-506, and Rapamycin

1994 • 51 citations

Cyclosporin a inhibits directly in vivo keratinocyte proliferation of living human skin

1989 • 48 citations

Cyclosporine in psoriasis treatment. Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming growth factor alpha/epidermal growth factor receptor pathways

1991 • 45 citations

Cyclosporin A Inhibits Directly In Vivo Keratinocyte Proliferation of Living Human Skin.

1989 • 30 citations

DNA Flow Cytometry on Human Epidermis: I. Methodological Studies on Normal Skin

1980 • 30 citations

Tacrolimus (FK 506)--a new therapeutic agent for severe recalcitrant psoriasis

1992 • 28 citations

Cannulation of difficult oesophageal strictures with angiographic catheters

1986 • 22 citations

Interleukin-1 Does Not Stimulate DNA Synthesis of Cultured Human Keratinocytes Growth-Arrested in Growth-Factor-Depleted Medium

1990 • 16 citations

Neither cyclosporin A nor FK506 affects adenylate cyclase responses of fetal rat keratinizing epidermal cells (FRSK cells) at concentrations that inhibit thymidine incorporation

1993 • 2 citations