Endonucleolytic Activity That Cleaves Immunoglobulin Recombination Sequences

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

The Bursa of Fabricius and Antibody Production

1956 • 701 citations

A complete immunoglobulin gene is created by somatic recombination.

1978 • 610 citations

Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.

1979 • 472 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes

1981 • 314 citations

A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation

1979 • 283 citations

In vitro generation of B lymphocytes in mouse foetal liver, a mammalian ‘bursa equivalent’

1974 • 210 citations

RecBC enzyme nicking at chi sites during DNA unwinding: Location and orientation-dependence of the cutting

1985 • 194 citations

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison.

1982 • 157 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

Translocation of the myc cellular oncogene to the immunoglobulin heavy chain locus in murine plasmacytomas is an imprecise reciprocal exchange

1984 • 128 citations

Transposition of the immunoglobulin heavy chain enhancer to the myc oncogene in a murine plasmacytoma

1985 • 97 citations

Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies.

1984 • 79 citations

Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line

1984 • 77 citations

Characterization of immunoglobulin enhancer deletions in murine plasmacytomas.

1985 • 72 citations

Double-stranded cleavage by cell extracts near recombinational signal sequences of immunoglobulin genes

1984 • 50 citations

Isolation and characterization of endonuclease J: a sequence-specific endonuclease cleaving immunoglobulin genes

1984 • 34 citations