IL4 and IL5: The role of two multifunctional cytokines and their place in the network of cytokine interactions

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

IL-4 is required to generate and sustain in vivo IgE responses.

1988 • 671 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

1986 • 529 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

1986 • 514 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

1987 • 449 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

1984 • 438 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Differential regulation of IgG1 and IgE synthesis by interleukin 4.

1988 • 389 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

T-cell and mast cell lines respond to B-cell stimulatory factor 1.

1986 • 381 citations

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

1988 • 359 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

1987 • 355 citations

Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5).

1987 • 322 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells.

1988 • 312 citations

Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4.

1988 • 303 citations

B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens.

1987 • 299 citations

Identification of a lymphokine that stimulates eosinophil differentiation in vitro. Its relationship to interleukin 3, and functional properties of eosinophils produced in cultures.

1985 • 296 citations

Interleukin-induced increase in Ia expression by normal mouse B cells.

1984 • 293 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

1988 • 285 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes.

1988 • 280 citations

Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells.

1987 • 268 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

An analysis of T cell responsiveness in Indian kala-azar.

1987 • 253 citations

Recombinant interleukin 4 promotes the growth of human T cells.

1987 • 252 citations

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes.

1987 • 251 citations

Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells.

1988 • 242 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

1987 • 237 citations

Isolation and characterization of lymphokine cDNA clones encoding mouse and human IgA-enhancing factor and eosinophil colony-stimulating factor activities: relationship to interleukin 5.

1987 • 236 citations

The Relationship Between Humoral and Cell‐Mediated Immunity

1972 • 228 citations

Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells

1987 • 213 citations

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

1987 • 212 citations

Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

1988 • 211 citations

B cell growth-promoting activity of recombinant human interleukin 4.

1987 • 211 citations

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

1988 • 208 citations

Immunological regulation of experimental cutaneous leishmaniasis. 1. Immunogenetic aspects of susceptibility to Leishmania tvopica in mice

1980 • 207 citations

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

1989 • 206 citations

Cloning of cDNA for human T-cell replacing factor (interieukin-5) and comparison with the murine homologue

1986 • 205 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

B-cell stimulatory factor 1 activates resting B cells.

1985 • 201 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4.

1986 • 194 citations

Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor

1987 • 193 citations

Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines.

1986 • 186 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

IL-4 inhibits IL-2-mediated induction of human lymphokine-activated killer cells, but not the generation of antigen-specific cytotoxic T lymphocytes in mixed leukocyte cultures.

1988 • 167 citations

Antigen-induced T cell-replacing factor (TRF). III. Establishment of T cell hybrid clone continuously producing TRF and functional analysis of released TRF.

1980 • 166 citations

Interleukin-4 mediates CDS induction on human CD4+ T-cell clones

1988 • 163 citations

Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).

1987 • 161 citations

B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide.

1987 • 154 citations

Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3.

1986 • 147 citations

Production of a B cell growth-promoting activity, (DL)BCGF, from a cloned T cell line and its assay on the BCL1 B cell tumor.

1982 • 140 citations

Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.

1987 • 140 citations

Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gamma.

1988 • 139 citations

Interferon-gamma suppresses B cell stimulation factor (BSF-1) induction of class II MHC determinants on B cells.

1986 • 138 citations

Murine B-cell stimulatory factor 1 (interleukin 4) increases expression of the Fc receptor for IgE on mouse B cells.

1987 • 137 citations

Interleukin 4 counteracts the interleukin 2-induced proliferation of monoclonal B cells.

1988 • 130 citations

Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages.

1987 • 128 citations

Inhibitory influence of IL-4 on human B cell responsiveness.

1988 • 123 citations

Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG_l and IgE

1988 • 119 citations

Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM.

1988 • 119 citations

B-cell growth factor (B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not induce cell growth.

1985 • 118 citations

Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny.

1987 • 116 citations

Interferon-gamma inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells.

1986 • 107 citations

Induction of class I and class II MHC antigen expression on murine bone marrow-derived macrophages by IL-4 (B cell stimulatory factor 1).

1988 • 105 citations

The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations.

1988 • 105 citations

Promotion of human T lymphocyte proliferation by IL-4.

1989 • 104 citations

IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide.

1988 • 101 citations

Interleukin 4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin 2.

1988 • 100 citations

Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells.

1987 • 99 citations

Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA.

1988 • 91 citations

Cognate interactions between helper T cells and B cells. III. Contact-dependent, lymphokine-independent induction of B cell cycle entry by activated helper T cells.

1989 • 90 citations

Recombinant interleukin 4/BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro.

1987 • 87 citations

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s).

1984 • 87 citations

Regulation of monocyte/macrophage C2 production and HLA-DR expression by IL-4 (BSF-1) and IFN-gamma.

1989 • 81 citations

A DNA Binding Protein Regulated by IL-4 and by Differentiation in B Cells

1988 • 79 citations

Immunomodulatory role of IL-4 on the secretion of Ig by human B cells.

1989 • 79 citations

Analysis by in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice.

1988 • 78 citations

Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody.

1985 • 77 citations

Human recombinant interleukin 4 induces normal B cells to produce soluble CD23/IgE‐binding factor analogous to that spontaneously released by lymphoblastoid B cell lines

1988 • 76 citations

Influence of recombinant IL-4, IFN-alpha, and IFN-gamma on the production of human IgE-binding factor (soluble CD23).

1989 • 76 citations

Interleukin 4 (IgG₁ induction factor): a multifunctional lymphokine acting also on T cells

1987 • 75 citations

Regulation of murine T cell proliferation by B cell stimulatory factor-1.

1987 • 71 citations

Fusion of Normal Rabbit Alveolar Macrophages Induced by Supernatant Fluids from BCG-Sensitized Lymph Node Cells After Elicitation by Antigen

1974 • 71 citations

Partial biochemical characterization of IgG₁‐inducing factor

1985 • 69 citations

Polyclonal activation of the murine immune system by an antibody to IgD. II. Generation of polyclonal antibody production and cells with surface IgG.

1982 • 68 citations

Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2.

1983 • 68 citations

Effects of IL-4 on macrophage functions: increased uptake and killing of a protozoan parasite (Trypanosoma cruzi).

1989 • 68 citations

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

1988 • 65 citations

High-efficiency purification and chemical characterization of B cell stimulatory factor-1/interleukin 4.

1987 • 64 citations

IL-4/B cell stimulatory factor 1 stimulates T cell growth by an IL-2-independent mechanism.

1988 • 62 citations

IL-4 (B cell-stimulatory factor 1) regulates multiple aspects of influenza virus-specific cell-mediated immunity.

1988 • 58 citations

A mouse T cell product that preferentially enhances IgA production. II. Physicochemical characterization.

1987 • 57 citations

TheIL-4 andIL-5 genes are closely linked and are part of a cytokine gene cluster on mouse chromosome 11

1989 • 57 citations

T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production.

1989 • 52 citations

IL-4-induced lymphokine-activated killer cells. Lytic activity is mediated by phenotypically distinct natural killer-like and T cell-like large granular lymphocytes.

1988 • 51 citations

Production of BSF-1 during an in vivo, T-dependent immune response.

1986 • 51 citations

Interferon-gamma is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes.

1987 • 50 citations

IL-4 induces the specific rearrangement of gamma 1 genes on the expressed and unexpressed chromosomes of lipopolysaccharide-activated normal murine B cells.

1989 • 45 citations

Lymphokine-mediated induction of antigen-presenting ability in thymic stromal cells.

1987 • 44 citations

Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5).

1987 • 40 citations

Interleukin 4 induces membrane Thy-1 expression on normal murine B cells.

1988 • 39 citations

Interleukin 4 enhances the ability of antigen-specific B cells to form conjugates with T cells.

1987 • 31 citations

Interleukin 5 and interleukin 2 cooperate with interleukin 4 to induce IgG1 secretion from anti-Ig-treated B cells.

1988 • 31 citations

Recombinant IL-4 and IFN-gamma activate locomotor capacity in human B lymphocytes.

1989 • 30 citations

Preferential proliferation of immature B lineage cells in long-term stromal cell-dependent cultures with IL-4.

1989 • 28 citations

Activation of IL 1-dependent and IL 1-independent T cell lines by calcium ionophore and phorbol ester.

1986 • 26 citations

Distinct patterns of lymphokine requirement for the proliferation of various subpopulations of activated thymocytes in a single cell assay.

1989 • 25 citations

Analysis of two distinct B cell activation pathways mediated by a monoclonal T helper cell. II. T helper cell secretion of interleukin 4 selectively inhibits antigen-specific B cell activation by cognate, but not noncognate, interactions with T cells.

1988 • 20 citations

Interleukin 4 (BSF-1) induces growth in resting murine CD8 T cells triggered via cross-linking of T3 cell surface structures

1988 • 18 citations

Characterization of murine cytolytic-helper hybrid T cell clones

1987 • 16 citations

T-helper cell subpopulations and the immune spectrum of leprosy.

1989 • 15 citations

Requirement for BSF-1 in the induction of antigen-specific B cell proliferation by a thymus-dependent antigen and carrier-reactive T cell line.

1987 • 10 citations

Constitutive production of lymphokines by cloned murine B-cell lymphomas--CH12 B lymphoma produces interleukin-4.

1989 • 10 citations

IL-2 and IL-4 stimulate different subpopulations of double-negative thymocytes.

1988 • 10 citations

B cell stimulatory factor 1 induces lobster agglutinin 1-separated mouse thymocytes to express cytotoxic T lymphocyte activity.

1988 • 7 citations