The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of multiple myeloma: An evidence-based review

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

1997 • 576 citations

Comparison of 200 mg/m2 melphalan and 8 Gy total body irradiation plus 140 mg/m2 melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial

2002 • 562 citations

High-Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation in Multiple Myeloma: Up-front or Rescue Treatment? Results of a Multicenter Sequential Randomized Clinical Trial

1998 • 553 citations

Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma

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Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients

1995 • 459 citations

Allogeneic Bone Marrow Transplantation in Multiple Myeloma

1991 • 389 citations

Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the European Group for Blood and Marrow Transplantation

1996 • 376 citations

Progress in allogeneic bone marrow and peripheral blood stem cell transplantation for multiple myeloma: a comparison between transplants performed 1983–93 and 1994–98 at European Group for Blood and Marrow Transplantation centres

2001 • 349 citations

High-dose melphalan with autologous bone marrow transplantation for multiple myeloma

1986 • 336 citations

Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities

2000 • 333 citations

Allogeneic marrow transplantation for multiple myeloma: an analysis of risk factors on outcome

1996 • 332 citations

Impact on survival of high-dose therapy with autologous stem cell support in patients younger than 60 years with newly diagnosed multiple myeloma: a population-based study

2000 • 317 citations

Donor Leukocyte Infusions Are Effective in Relapsed Multiple Myeloma After Allogeneic Bone Marrow Transplantation

1997 • 315 citations

Prognostic factors in allogeneic bone marrow transplantation for multiple myeloma.

1995 • 301 citations

Results of autologous stem cell transplant in multiple myeloma patients with renal failure

2001 • 300 citations

Donor Lymphocyte Infusions for Relapsed Multiple Myeloma After Allogeneic Stem-Cell Transplantation: Predictive Factors for Response and Long-Term Outcome

2000 • 299 citations

Transplantation of CD34+ peripheral blood progenitor cells after high- dose chemotherapy for patients with advanced multiple myeloma

1995 • 272 citations

High-dose chemoradiotherapy and autologous bone marrow transplantation for resistant multiple myeloma

1987 • 270 citations

Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma

2001 • 267 citations

Molecular and Clinical Remissions in Multiple Myeloma: Role of Autologous and Allogeneic Transplantation of Hematopoietic Cells

1999 • 253 citations

Age Is Not a Prognostic Variable With Autotransplants for Multiple Myeloma

1999 • 242 citations

Autologous stem cell transplantation in elderly multiple myeloma patients over the age of 70 years

2001 • 232 citations

High-dose melphalan and autologous bone marrow transplantation as consolidation in previously untreated myeloma.

1994 • 223 citations

T-cell–depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft-versus-myeloma effect

2001 • 218 citations

INTENSIVE TREATMENT OF MULTIPLE MYELOMA AND CRITERIA FOR COMPLETE REMISSION

1989 • 204 citations

Purging of Autologous Peripheral-Blood Stem Cells Using CD34 Selection Does Not Improve Overall or Progression-Free Survival After High-Dose Chemotherapy for Multiple Myeloma: Results of a Multicenter Randomized Controlled Trial

2001 • 201 citations

High response rate in refractory and poor-risk multiple myeloma after allotransplantation using a nonmyeloablative conditioning regimen and donor lymphocyte infusions

2001 • 196 citations

Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants.

1997 • 187 citations

Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning

2002 • 186 citations

Donor leukocyte infusions for multiple myeloma

2000 • 186 citations

Concomitant mobilization of plasma cells and hematopoietic progenitors into peripheral blood of multiple myeloma patients: positive selection and transplantation of enriched CD34+ cells to remove circulating tumor cells

1996 • 184 citations

Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support

1992 • 177 citations

Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma.

1999 • 175 citations

A randomized trial of maintenance interferon following high‐dose chemotherapy in multiple myeloma: long‐term follow‐up results

1998 • 174 citations

Molecular Remission After Allogeneic or Autologous Transplantation of Hematopoietic Stem Cells for Multiple Myeloma

2000 • 173 citations

High-dose therapy for refractory multiple myeloma: improved prognosis with better supportive care and double transplants

1994 • 172 citations

Overall and event-free survival are not improved by the use of myeloablative therapy following intensified chemotherapy in previously untreated patients with multiple myeloma: a prospective randomized phase 3 study

2003 • 168 citations

Preceding standard therapy is the likely cause of MDS after autotransplants for multiple myeloma

1996 • 164 citations

Dose-Intensive Melphalan With Stem Cell Support (MEL100) Is Superior to Standard Treatment in Elderly Myeloma Patients

1999 • 163 citations

Immunophenotypic evaluation of the plasma cell compartment in multiple myeloma: a tool for comparing the efficacy of different treatment strategies and predicting outcome

2002 • 159 citations

Autotransplants in multiple myeloma: what have we learned?

1996 • 157 citations

Treatment of aggressive multiple myeloma by high-dose chemotherapy and total body irradiation followed by blood stem cells autologous graft

1989 • 157 citations

Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

1999 • 156 citations

Intensive combined therapy for previously untreated aggressive myeloma

1992 • 151 citations

A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain Reaction

1998 • 150 citations

High-dose sequential chemoradiotherapy in multiple myeloma: residual tumor cells are detectable in bone marrow and peripheral blood cell harvests and after autografting

1995 • 145 citations

Low-risk intensive therapy for multiple myeloma with combined autologous bone marrow and blood stem cell support

1992 • 143 citations

Salvage autologous or allogeneic transplantation for multiple myeloma refractory to or relapsing after a first-line autograft?

1998 • 141 citations

Impact of complete remission with intensive therapy in patients with responsive multiple myeloma

2001 • 140 citations

High-dose chemoradiotherapy and autologous blood stem cell transplantation in multiple myeloma: results of a phase II trial involving 63 patients

1993 • 138 citations

Double-intensive therapy in high-risk multiple myeloma

1992 • 133 citations

Autologous bone marrow transplantation in multiple myeloma: identification of prognostic factors

1990 • 130 citations

High‐sensitive immunophenotyping and DNA ploidy studies for the investigation of minimal residual disease in multiple myeloma

1999 • 129 citations

Safety of autotransplants with high-dose melphalan in renal failure: a pharmacokinetic and toxicity study.

1996 • 129 citations

Thiotepa, busulfan, and cyclophosphamide: a new preparative regimen for autologous marrow or blood stem cell transplantation in high-risk multiple myeloma

1993 • 128 citations

Early myeloablative therapy for multiple myeloma

1994 • 123 citations

High-dose melphalan with autologous bone marrow transplantation for multiple myeloma

1986 • 119 citations

Autotransplants in multiple myeloma: what have we learned?

1996 • 118 citations

The role of autologous transplantation in patients with multiple myeloma aged 65 years and over

2000 • 116 citations

The impact of attaining a minimal disease state after high‐dose melphalan and autologous transplantation for multiple myeloma

2001 • 114 citations

High-dose therapy followed by autologous hematopoietic stem-cell infusion for patients with multiple myeloma.

1996 • 114 citations

Remission status defined by immunofixation vs. electrophoresis after autologous transplantation has a major impact on the outcome of multiple myeloma patients

2000 • 112 citations

Transplantation with selected autologous peripheral blood CD34+Thy1+ hematopoietic stem cells (HSCs) in multiple myeloma

2000 • 111 citations

STERILISATION BY HYSTERECTOMY

1970 • 109 citations

Monoclonal antibody-purged bone marrow transplantation therapy for multiple myeloma

1993 • 108 citations

Incidence and Impact of Light Chain Associated (AL) Amyloidosis on the Prognosis of Patients with Multiple Myeloma Treated with Autologous Transplantation

1997 • 106 citations

Cytogenetic Abnormalities Correlate with the Plasma Cell Labeling Index and Extent of Bone Marrow Involvement in Myeloma

1999 • 105 citations

Monoclonal antibody-purged autologous bone marrow transplantation therapy for multiple myeloma

1991 • 104 citations

Molecular monitoring of minimal residual disease in patients in long-term complete remission after allogeneic stem cell transplantation for multiple myeloma

2000 • 102 citations

Melphalan 220 mg/m2 followed by peripheral blood stem cell transplantation in 27 patients with advanced multiple myeloma

1999 • 101 citations

Autologous bone marrow transplantation in multiple myeloma: identification of prognostic factors

1990 • 101 citations

Feasibility and cost-effectiveness of outpatient autotransplants in multiple myeloma

1997 • 100 citations

Alpha-interferon maintenance treatment is associated with improved survival after high-dose treatment and autologous stem cell transplantation in patients with multiple myeloma: a retrospective registry study from the European Group for Blood and Marrow Transplantation (EBMT)

2001 • 100 citations

Double-intensive therapy in high-risk multiple myeloma

1992 • 98 citations

Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in multiple myeloma

2000 • 98 citations

Double high-dose chemoradiotherapy with autologous stem cell transplantation can induce molecular remissions in multiple myeloma.

1995 • 97 citations

Predicting long‐term (≥ 5 years) event‐free survival in multiple myeloma patients following planned tandem autotransplants

2002 • 93 citations

Relapse of multiple myeloma after autologous transplantation: survival after salvage therapy.

1995 • 91 citations

Quantitative comparison of multiple myeloma tumor contamination in bone marrow harvest and leukapheresis autografts.

1996 • 90 citations

Syngeneic transplantation in multiple myeloma – a case-matched comparison with autologous and allogeneic transplantation

1999 • 88 citations

Autologous peripheral blood stem cell transplantation for multiple myeloma: a report of 259 cases from the Spanish Registry

1998 • 88 citations

Thiotepa, busulfan, and cyclophosphamide: a new preparative regimen for autologous marrow or blood stem cell transplantation in high-risk multiple myeloma

1993 • 87 citations

Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy

2000 • 83 citations

High-dose sequential chemoradiotherapy, a widely applicable regimen, confers survival benefit to patients with high-risk multiple myeloma.

1994 • 82 citations

High-Dose Melphalan With Autotransplantation for Refractory Multiple Myeloma: Results of a Southwest Oncology Group Phase II Trial

1999 • 81 citations

Safety of autologous hematopoietic stem cell transplantation in patients with multiple myeloma and chronic renal failure

2000 • 80 citations

Conditioning regimens in autologous stem cell transplantation for multiple myeloma: a comparative study of efficacy and toxicity from the Spanish Registry for Transplantation in Multiple Myeloma

2000 • 78 citations

Allogeneic transplantation for multiple myeloma: further evidence for a GVHD-associated graft-versus-myeloma effect

2001 • 75 citations

Plasmablastic Morphology Is an Independent Predictor of Poor Survival After Autologous Stem-Cell Transplantation for Multiple Myeloma

1999 • 73 citations

High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency

1997 • 73 citations

Outcome assessment of a population-based group of 195 unselected myeloma patients under 70 years of age offered intensive treatment

1997 • 72 citations

Autologous stem cell transplantation for relapsed and primary refractory myeloma

1999 • 71 citations

Methods for estimation of bone marrow plasma cell involvement in myeloma: Predictive value for response and survival in patients undergoing autologous stem cell transplantation

2001 • 69 citations

High-dose busulfan and cyclophosphamide are an effective conditioning regimen for allogeneic bone marrow transplantation in chemosensitive multiple myeloma

1998 • 65 citations

Prognostic Factors in Autologous Stem Cell Transplantation for Multiple Myeloma: An EBMT Registry Study

1994 • 64 citations

Limited value of myeloablative therapy for late multiple myeloma

1994 • 63 citations

Bone marrow transplantation in multiple myeloma: report from the European Cooperative Group for Bone Marrow Transplantation

1987 • 61 citations

Treatment of multiple myeloma with intensive chemotherapy followed by autologous BMT using marrow purged with 4-hydroperoxycyclophosphamide.

1993 • 59 citations

The role of cytotoxic therapy with hematopoietic stem cell transplantation in the therapy of diffuse large cell B-cell non-Hodgkin's lymphoma: An evidence-based review

2001 • 59 citations

Melphalan plus total body irradiation (MEL-TBI) or cyclophosphamide (MEL-CY) as a conditioning regimen with second autotransplant in responding patients with myeloma is inferior compared to historical controls receiving tandem transplants with melphalan alone

2000 • 57 citations

Syngeneic marrow transplantation in patients with multiple myeloma.

1996 • 56 citations

Autologous stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation

2000 • 56 citations

Persistent preswitch clonotypic myeloma cells correlate with decreased survival: evidence for isotype switching within the myeloma clone

2001 • 56 citations

Mature plasma cells as indicator of better prognosis in multiple myeloma. New methodology for the assessment of plasma cell morphology

1999 • 54 citations

Abnormal cytogenetics predict poor survival after high-dose therapy and autologous blood cell transplantation in multiple myeloma

1999 • 54 citations

Myeloma cell contamination of peripheral blood stem cell grafts in patients with multiple myeloma treated by high-dose therapy.

1994 • 54 citations

Comparison of myeloma cell contamination of bone marrow and peripheral blood stem cell harvests

1996 • 54 citations

Comparison of autologous bone marrow transplantation and peripheral blood stem cell transplantation after first remission induction treatment in multiple myeloma.

1995 • 53 citations

Allogeneic transplantation of unmanipulated peripheral blood stem cells in patients with multiple myeloma

1998 • 52 citations

Treatment of myeloma using intensive therapy and allogeneic bone marrow transplantation.

1995 • 52 citations

Long-term follow-up after high-dose therapy for high-risk multiple myeloma

1998 • 51 citations

Consensus strategy to quantitate malignant cells in myeloma patients is validated in a multicenter study

2000 • 50 citations

Myeloablative Treatments for Multiple Myeloma: Update of a Comparative Study of Different Regimens Used in Patients from the Spanish Registry for Transplantation in Multiple Myeloma

2002 • 50 citations

High dose cyclophosphamide, BCNU and VP-16 with autologous blood stem cell support for refractory multiple myeloma.

1990 • 50 citations

First and second apheresis in patients with multiple myeloma: no differences in tumor load and hematopoietic stem cell yield

1998 • 49 citations

Autologous CD34-selected blood progenitor cell transplants for patients with advanced multiple myeloma

1998 • 49 citations

Decrease of bone marrow angiogenesis in myeloma patients achieving a remission after chemotherapy

2001 • 48 citations

ABO mismatch may affect engraftment in multiple myeloma patients receiving nonmyeloablative conditioning

2002 • 48 citations

High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma

1997 • 47 citations

Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma

2000 • 46 citations

Autologous transplantation of mobilized peripheral blood CD34+ cells selected by immunomagnetic procedures in patients with multiple myeloma

1998 • 45 citations

Bone Marrow Transplantation in Patients with Multiple Myeloma

2001 • 45 citations

Negative selection of peripheral blood stem cells to support a tandem autologous transplantation programme in multiple myeloma

2002 • 44 citations

Delayed stem cell transplantation for the management of relapsed or refractory multiple myeloma

2000 • 43 citations

CD34⁺‐selected peripheral blood progenitor cell transplantation in patients with multiple myeloma: tumour cell contamination and outcome

1999 • 43 citations

Allogeneic stem cell transplantation reduces disease progression compared to autologous transplantation in patients with multiple myeloma

2001 • 42 citations

Cost–utility analysis of high‐dose melphalan with autologous blood stem cell support vs. melphalan plus prednisone in patients younger than 60 years with multiple myeloma

2001 • 42 citations

Radiation-associated pneumonitis following autologous stem cell transplantation: predictive factors, disease characteristics and treatment outcomes

2001 • 42 citations

Busulfan and melphalan as conditioning regimen for autologous peripheral blood stem cell transplantation in multiple myeloma

1995 • 41 citations

Analysis of circulating tumor cells in patients with multiple myeloma during the course of high-dose therapy with peripheral blood stem cell transplantation

1999 • 41 citations

Thiotepa, busulfan, cyclophosphamide (TBC) and autologous hematopoietic transplantation: an intensive regimen for the treatment of multiple myeloma

2001 • 40 citations

Early harvest and late transplantation as an effective therapeutic strategy in multiple myeloma

1999 • 40 citations

Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma

1995 • 40 citations

An economic evaluation of peripheral blood stem cell transplantation as an alternative to autologous bone marrow transplantation in multiple myeloma.

1996 • 39 citations

Autologous peripheral blood stem cell transplantation as first line treatment of multiple myeloma: an Italian Multicenter Study.

2000 • 38 citations

Impact of previous high-dose therapy on outcome after allografting for multiple myeloma

1999 • 38 citations

High-dose busulfan in patients with myeloma.

1992 • 38 citations

Induction therapy with vincristine, adriamycin, dexamethasone (VAD) and intermediate-dose melphalan (IDM) followed by autologous or allogeneic stem cell transplantation in newly diagnosed multiple myeloma

1999 • 38 citations

Comparative survival, quality of life and cost-effectiveness of intensive therapy with autologous blood cell transplantation or conventional chemotherapy in multiple myeloma.

1995 • 37 citations

Glomerular filtration rate prior to high-dose melphalan 200 mg/m2as a surrogate marker of outcome in patients with myeloma

2001 • 37 citations

Autologous and allogeneic transplantation for multiple myeloma at a single centre

1997 • 36 citations

Beta2-microglobulin and bone marrow plasma cell involvement predict complete responders among patients undergoing blood cell transplantation for myeloma

1999 • 36 citations

Autologous peripheral-blood progenitor-cell support following high-dosechemotherapy or chemoradiotherapy in patients with high-risk multiple myeloma.

1996 • 36 citations

Autologous transplantation in multiple myeloma: a GITMO retrospective analysis on 290 patients. Gruppo Italiano Trapianti di Midollo Osseo.

1999 • 36 citations

Selection and Transplantation of Autologous Hematopoietic CD34⁺Cells for Patients with Multiple Myeloma

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Monoclonal Antibody-Purged Bone Marrow Transplantation Therapy for Multiple Myeloma

1995 • 35 citations

Immunotherapy by non-myeloablative allogeneic stem cell transplantation in multiple myeloma: results of a pilot study as salvage therapy after autologous transplantation

2001 • 35 citations

Detection of malignant B cells in peripheral blood stem cell collections after chemotherapy in patients with multiple myeloma.

1995 • 35 citations

CD34+ selection of autologous peripheral blood stem cells for transplantation following sequential cycles of high-dose therapy and mobilisation in multiple myeloma

2000 • 33 citations

Intensive chemotherapy with blood progenitor transplantation for primary resistant multiple myeloma

1994 • 31 citations

Autologous transplantation in multiple myeloma : a GITMO retrospective analysis on 290 patients

1999 • 31 citations

Selection and transplantation of autologous CD34⁺ B‐lineage negative cells in advanced‐phase multiple myeloma patients: a pilot study

1999 • 31 citations

Frequency and kinetics of polyclonal and clonal B cells in the peripheral blood of patients being treated for multiple myeloma

2000 • 30 citations

Concomitant Mobilization of Plasma Cells and Hematopoietic Progenitors into Peripheral Blood of Patients with Multiple Myeloma

1996 • 28 citations

Patients with multiple myeloma may safely undergo autologous transplantation despite ongoing RSV infection and no ribavirin therapy

1999 • 27 citations

Clinical utility of immunoglobulin heavy chain gene rearrangement identification for tumour cell detection in multiple myeloma

1998 • 27 citations

Plasma cells in peripheral blood stem cell harvests from patients with multiple myeloma are predominantly polyclonal

1997 • 27 citations

Deletion of chromosome 13q14 detected by fluorescence in situ hybridization has prognostic impact on survival after high-dose therapy in patients with multiple myeloma

2001 • 26 citations

Comparison of marrow vs blood-derived stem cells for autografting in previously untreated multiple myeloma

1997 • 26 citations

Multiple myeloma: the number of reinfused plasma cells does not influence outcome of patients treated with intensified chemotherapy and PBPC support

2000 • 26 citations

Collection of peripheral blood stem cells after a preceding autograft: unfavorable effect of prior interferon-α therapy

1999 • 25 citations

Cost‐effectiveness of high‐dose chemotherapy in first‐line treatment of advanced multiple myeloma

2001 • 25 citations

Transplantation in Patients With Multiple Myeloma

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The costs of peripheral blood progenitor cell reinfusion mobilised by granulocyte colony-stimulating factor following high dose melphalan as compared with conventional therapy in multiple myeloma

1994 • 23 citations

Treatments for newly diagnosed multiple myeloma: analysis of survival data and cost-effectiveness evaluation.

1998 • 23 citations

Maintenance treatment with recombinant alpha interferon after autologous bone marrow transplantation for aggressive myeloma in first remission after conventional induction chemotherapy.

1991 • 23 citations

Clinical and molecular follow-up by amplification of the CDR-III IgH region in multiple myeloma patients after autologous transplantation of hematopoietic CD34+ stem cells.

1999 • 22 citations

The detection of contaminating clonal cells in apheresis products is related to response and outcome in multiple myeloma undergoing autologous peripheral blood stem cell transplantation

2000 • 22 citations

Multicyclic, dose-intensive chemotherapy supported by hemopoietic progenitors in refractory myeloma patients

1997 • 22 citations

Reduced progression-free survival in elderly patients receiving intensification with autologous peripheral blood stem cell reinfusion for multiple myeloma

1998 • 22 citations

Efficacy and safety of CD34-selected and CD19-depleted autografting in multiple myeloma patients

2002 • 21 citations

Comparison of new patients with Bence-Jones, IgG and IgA myeloma receiving sequential therapy: the need to regard these immunologic subtypes as separate disease entities with specific prognostic criteria

2001 • 21 citations

Dose-intensive melphalan with stem cell support (CM regimen) is effective and well tolerated in elderly myeloma patients.

2000 • 21 citations

A comparison of CD34+ cell selected and unselected autologous peripheral blood stem cell transplantation for multiple myeloma: a case controlled analysis

1999 • 20 citations

Allogeneic bone marrow transplantation in 24 patients with multiple myeloma reported to the ebmt registry

1988 • 19 citations

Gene scanning of VDJH-amplified segments is a clinically relevant technique to detect contaminating tumor cells in the apheresis products of multiple myeloma patients undergoing autologous peripheral blood stem cell transplantation

2001 • 19 citations

Factors influencing platelet recovery after blood cell transplantation in multiple myeloma

1997 • 19 citations

High-dose idarubicine, busulphan and melphalan as conditioning for autologous blood stem cell transplantation in multiple myeloma. A feasibility study

2000 • 18 citations

Peripheral Blood Progenitor Cell Transplantation in Multiple Myeloma Following High-Dose Melphalan-Based Therapy

1998 • 17 citations

Refractory and Relapsing Multiple Myeloma Treated by Blood Stem Cell Transplantation

1995 • 17 citations

High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma

1996 • 16 citations

Repeat administration of high dose melphalan in relapsed myeloma

1993 • 15 citations

High-dose therapy in multiple myeloma: effect of positive selection of CD34+ peripheral blood stem cells on hematologic engraftment and clinical outcome.

2000 • 15 citations

Comparison of Interferon Tolerance after Autologous Bone Marrow or Peripheral Blood Stem Cell Transplants for Myeloma Patients who have Responded to Induction Therapy

1996 • 14 citations

Linear reduction of clonal cells in stem cell enriched grafts in transplanted multiple myeloma

1999 • 14 citations

Allogeneic bone marrow transplantation in patients with multiple myeloma

1989 • 13 citations

ASBMT Policy Statement Regarding the Methodology of Evidence-Based Reviews in Evaluating the Role of Blood and Marrow Transplantation in the Treatment of Selected Diseases

2000 • 11 citations

Flow cytometric DNA quantification in immunophenotyped cells as a sensitive method for determination of aneuploid multiple myeloma cells in peripheral blood stem cell harvests and bone marrow after therapy

1999 • 10 citations

High-dose chemotherapy with carboplatin, cyclophosphamide and etoposide and autologous transplantation for multiple myeloma relapsing after a previous transplant

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Costs of intensive treatment and follow-up of patients with multiple myeloma

1998 • 10 citations

Autografting for multiple myeloma: a 5-year experience at a single institution.

1995 • 10 citations

Evidence-Based Reviews and the Role of Blood and Marrow Transplantation in the Treatment of Selected Diseases: An ASBMT Policy Statement

2000 • 10 citations

Role of CD34+ cells in engraftment after high-dose melphalan in multiple myeloma patients given peripheral blood stem cell rescue.

1996 • 9 citations

Intensive Sequential Therapy for VAD-Resistant Multiple Myeloma

1994 • 8 citations

Evaluation of minimal residual disease by interphase FISH in multiple myeloma: does complete remission exist?

1999 • 7 citations

Molecular and clinical follow-up after stem cell transplantation for multiple myeloma

2001 • 6 citations

Interphase FISH: a rapid method for detecting malignant plasma cells in multiple myeloma patients submitted to autologous transplantation

1999 • 6 citations

Myeloma during a decade: Clinical experience in a single centre

1995 • 6 citations

The Significance of Light Chain-Restricted Bone Marrow Plasma Cells After Peripheral Blood Stem Cell Transplantation for Multiple Myeloma

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An incremental response to high-dose therapy in multiple myeloma.

1996 • 6 citations

Autologous Bone Marrow Transplantation in Multiple Myeloma: A Single Centre Experience of 23 Patients

1994 • 5 citations

Treatment of Multiple Myeloma with Autologous Blood Stem Cell Transplantation. Preliminary Results of an Italian Multicentric Pilot Study

1993 • 4 citations