Autoimmunity and Diabetes

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes

1998 • 642 citations

Requirements for CD1d Recognition by Human Invariant Vα24+ CD4−CD8− T Cells

1997 • 527 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1998 • 454 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups

1997 • 408 citations

A Human Endogenous Retroviral Superantigen as Candidate Autoimmune Gene in Type I Diabetes

1997 • 404 citations

Early quantitative and functional deficiency of NK1⁺‐like thymocytes in the NOD mouse

1996 • 359 citations

Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus

1990 • 335 citations

β cell apoptosis in T cell-mediated autoimmune diabetes

1997 • 330 citations

Susceptibility to type I diabetes: HLA-DQ and DR revisited

1996 • 324 citations

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

1994 • 311 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

The Role of Macrophages in T Cell–mediated Autoimmune Diabetes in Nonobese Diabetic Mice

1999 • 279 citations

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

1986 • 243 citations

T-Cell Epitopes in Type 1 Diabetes Autoantigen Tyrosine Phosphatase IA-2: Potential for Mimicry with Rotavirus and Other Environmental Agents

1998 • 213 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

Cellular and Molecular Mechanisms for the Initiation and Progression of β Cell Destruction Resulting from the Collaboration Between Macrophages and T Cells

1998 • 164 citations

Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?

1986 • 146 citations

Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes

1998 • 140 citations

An Epstein-Barr virus-associated superantigen.

1996 • 140 citations

Close phenotypic and functional similarities between human and murine alphabeta T cells expressing invariant TCR alpha-chains.

1997 • 135 citations

Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in sardinia

1993 • 120 citations

Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.

1995 • 115 citations

Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

1995 • 106 citations

Molecular mimicry in diabetes mellitus: the homologous domain in coxsackie B virus protein 2C and islet autoantigen GAD 65 is highly conserved in the coxsackie B-like enteroviruses and binds to the diabetes associated HLA-DR3 molecule

1998 • 103 citations

The distribution of DR4 haplotypes in sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci

1995 • 96 citations

Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus

1994 • 91 citations

DRB1*0403 Protects Against IDDM in Caucasians With the High-Risk Heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 Genotype

1995 • 75 citations

HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population

1995 • 71 citations

An Immunohistochemical Study on Organized Lymphoid Cell Infiltrates in Fetal and Neonatal Pancreases: A comparison with similar infiltrates found in the pancreas of a diabetic infant

1993 • 59 citations

HLA‐DRB1*0401 IS ASSOCIATED WITH SUSCEPTIBILITY TO INSULIN‐DEPENDENT DIABETES MELLITUS INDEPENDENTLY OF THE DQB1 LOCUS

1995 • 50 citations

Insulin-dependent diabetes mellitus: the hypothesis of molecular mimicry between islet cell antigens and microorganisms

1997 • 49 citations

HERV-K10s and Immune-Mediated (Type 1) Diabetes

1998 • 39 citations

Contribution of DRB1*04 Variants to Predisposition to or Protection from Insulin Dependent Diabetes Mellitus is Independent of DQ

1996 • 32 citations

HLA class II-associated predisposition to insulin-dependent diabetes mellitus in a Polish population

1998 • 28 citations

Dendritic Cells in the Autoimmune Insulitis in NOD Mouse Models of Diabetes

1997 • 23 citations

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