Receptor-mediated events and the evaluation of the Environmental Protection Agency (EPA) of dioxin risks*1

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Textbook of Endocrinology

1952 • 1,475 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Peptide Growth Factors and Their Receptors

1991 • 1,221 citations

Principles of Drug Action: The Basis of Pharmacology.

1975 • 616 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

Mechanisms of Carcinogenesis in Risk Identification

1992 • 341 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

The Dose—Response Relation in Pharmacology

1979 • 273 citations

The Epidermal Growth Factor Family

1991 • 260 citations

Thyroid follicular cell carcinogenesis*1

1989 • 260 citations

Biological Basis for Risk Assessment of Dioxins and Related Compounds

1991 • 212 citations

Enhanced Thyroxine Metabolism and High Uptake Goiters in Rats After a Single Dose of 2,3,7,8- Tetrachlorodibenzo-p-Dioxin1¹

1977 • 201 citations

A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci

1987 • 197 citations

Progress in Cancer Research and Therapy.

1978 • 195 citations

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

1990 • 189 citations

UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism

1992 • 172 citations

Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction.

1994 • 158 citations

Epidermal growth factor receptor number decreases during rat liver regeneration.

1981 • 151 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

1992 • 146 citations

TCDD alters medial epithelial cell differentiation during palatogenesis

1989 • 117 citations

Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi

1991 • 117 citations

A Mechanistic Model of Effects of Dioxin on Gene Expression in the Rat Liver

1993 • 115 citations

Dioxin induces transforming growth factor-alpha in human keratinocytes

1991 • 114 citations

TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD

1990 • 111 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) as a potent and persistent thyroxine agonist: a mechanistic model for toxicity based on molecular reactivity.

1985 • 103 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

Regulation of epidermal growth factor binding in a human keratinocyte cell line by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1985 • 98 citations

Changes in thyroid hormones and thyroxine glucuronidation in hamsters compared with rats following treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1987 • 89 citations

Dose-dependent elevation of Ah receptor binding by TCDD in rat liver

1987 • 81 citations

Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

1993 • 75 citations

Dioxins and the ah receptor

1989 • 74 citations

Dioxin Risks Revisited

1991 • 74 citations

Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment

1993 • 73 citations

Effects of TCDD on embryonic ureteric epithelial EGF receptor expression and cell proliferation

1990 • 65 citations

Structure, function and transforming potential of the epidermal growth factor receptor

1990 • 64 citations

2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

1988 • 60 citations

TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD

1993 • 58 citations

Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.

1991 • 56 citations

Goitres in rats fed polychlorinated biphenyls

1977 • 54 citations

Humans are a sensitive species to some of the biochemical effects of structural analogs of dioxin

1991 • 44 citations

Patterns of ligand binding to normal, regenerating, preneoplastic, and neoplastic rat hepatocytes.

1987 • 41 citations

Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.

1988 • 30 citations

Mechanism of action of peptide hormones and catecholamines

1985 • 27 citations

Independent mechanisms for tumor promoters phenobarbital and 12-O-tetradecanoylphorbol-13-acetate in reduction of epidermal growth factor binding by rat hepatocytes.

1989 • 26 citations

Receptor-mediated carcinogenesis.

1992 • 24 citations

Neoplastic transformation of immortalized human keratinocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1992 • 23 citations

Chronic treatment with phenobarbital decreases the expression of rat liver EGF and insulin receptors

1986 • 22 citations

EPA Moves to Reassess the Risk of Dioxin

1991 • 14 citations

Binding of epidermal growth factor and insulin and the autophosphorylation of their receptors in experimental primary hepatocellular carcinomas.

1986 • 12 citations

More Pieces in the Dioxin Puzzle

1991 • 11 citations