The 12-transmembrane helix transporters

Membrane protein structure prediction

1992 • 1,680 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

1993 • 939 citations

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

1992 • 594 citations

Isolation and characterization of a sucrose carrier cDNA from spinach by functional expression in yeast.

1992 • 479 citations

A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism

1993 • 411 citations

Emr, an Escherichia coli locus for multidrug resistance.

1992 • 410 citations

Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.

1993 • 370 citations

Proton-Coupled Sugar and Amino Acid Transporters in Plants

1993 • 359 citations

The PH084 Gene of Saccharomyces cerevisiae Encodes an Inorganic Phosphate Transporter

1991 • 350 citations

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

1993 • 347 citations

Membrane transport proteins: implications of sequence comparisons

1992 • 330 citations

The PHO84 gene of Saccharomyces cerevisiae encodes an inorganic phosphate transporter.

1991 • 276 citations

Yeast Sugar Transporters

1993 • 264 citations

The synaptic vesicle protein SV2 is a novel type of transmembrane transporter

1992 • 257 citations

SV2, a Brain Synaptic Vesicle Protein Homologous to Bacterial Transporters

1992 • 244 citations

Primary structure, genomic organization and heterologous expression of a glucose transporter from Arabidopsis thaliana.

1990 • 230 citations

Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli.

1987 • 223 citations

Mammalian facilitative glucose transporters: Evidence for similar substrate recognition sites in functionally monomeric proteins

1992 • 198 citations

Alkali Cation Transport Systems in Prokaryotes

2024 • 197 citations

Secondary solute transport in bacteria

1993 • 193 citations

Does Fourier-transform infrared spectroscopy provide useful information on protein structures?

1992 • 188 citations

Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.

1992 • 168 citations

Glucose transporter oligomeric structure determines transporter function. Reversible redox-dependent interconversions of tetrameric and dimeric GLUT1.

1992 • 168 citations

Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family.

1992 • 163 citations

Isolation and Sequencing of Escherichia coli Gene proP Reveals Unusual Structural Features of the Osmoregulatory Proline/Betaine transporter, ProP

1993 • 163 citations

Proton-linked sugar transport systems in bacteria

1990 • 154 citations

Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase.

1992 • 146 citations

Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant.

1993 • 135 citations

The Na+/H+ exchanger: an update on structure, regulation and cardiac physiology

1993 • 120 citations

What we can learn from the effects of thiol reagents on transport proteins

1992 • 109 citations

Membrane topology of the pBR322 tetracycline resistance protein. TetA-PhoA gene fusions and implications for the mechanism of TetA membrane insertion.

1992 • 109 citations

Molecular Aspects of Transport Proteins

1992 • 109 citations

Mutagenesis of acidic residues in putative membrane-spanning segments of the melibiose permease of Escherichia coli. I. Effect on Na(+)-dependent transport and binding properties.

1993 • 98 citations

Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132

1992 • 97 citations

Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae.

1992 • 96 citations

Molecular genetics of intestinal glucose transport.

1991 • 91 citations

Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding.

1992 • 86 citations

Cloning and sequence analysis of an Escherichia coli gene conferring bicyclomycin resistance

1993 • 84 citations

Possible salt bridges between transmembrane alpha-helices of the lactose carrier of Escherichia coli.

1992 • 82 citations

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. Roles of the aspartyl residues located in the putative transmembrane helices.

1992 • 80 citations

Membrane topology of the melibiose carrier of Escherichia coli.

1992 • 80 citations

The lysP gene encodes the lysine-specific permease

1992 • 80 citations

Revised nucleotide sequence of the gltP gene, which encodes the proton-glutamate-aspartate transport protein of Escherichia coli K-12

1992 • 74 citations

The dynamics of the glucose transporter

1988 • 70 citations

Membrane protein spanning segments as export signals

1992 • 69 citations

In and Out and Up and Down with Lac Permease

1992 • 61 citations

Replacement of intracellular C-terminal domain of GLUT1 glucose transporter with that of GLUT2 increases Vmax and Km of transport activity.

1992 • 61 citations

Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier

1992 • 58 citations

A new family of integral membrane proteins involved in transport of aromatic amino acids in Escherichia coli

1991 • 55 citations

Topology of the Escherichia coli uhpT sugar-phosphate transporter analyzed by using TnphoA fusions

1990 • 53 citations

Sugar—Cation Symport Systems in Bacteria

1992 • 51 citations

Functional expression of a plant plasma membrane transporter in Xenopus oocytes

1992 • 50 citations

Atomic interactions in protein-carbohydrate complexes

1992 • 48 citations

Expression of the tetK gene from Staphylococcus aureus in Escherichia coli: comparison of substrate specificities of TetA(B), TetA(C), and TetK efflux proteins

1993 • 44 citations

Baculovirus-mediated expression of the Na+/glucose cotransporter in Sf9 cells

1992 • 41 citations

Sequential truncation of the lactose permease over a three-amino acid sequence near the carboxyl terminus leads to progressive loss of activity and stability.

1991 • 33 citations

Functional role of arginine 302 within the lactose permease of Escherichia coli.

1992 • 31 citations

Ribose and glucose-galactose receptors

1992 • 30 citations

Evidence that the final turn of the last transmembrane helix in the lactose permease is required for folding.

1992 • 29 citations

Nucleotide and deduced protein sequences of the class D tetracycline resistance determinant: relationship to other antimicrobial transport proteins

1993 • 29 citations

The N-terminal 22 amino acid residues in the lactose permease of Escherichia coli are not obligatory for membrane insertion or transport activity.

1992 • 29 citations

The lactose permease ofEscherichia coli: a paradigm for membrane transport proteins

1992 • 28 citations

Functional complementation of internal deletion mutants in the lactose permease of Escherichia coli.

1992 • 28 citations

Molecular biology approaches to comparative study of Na(+)-glucose cotransport

1992 • 26 citations

Primary structure and characteristics of the melibiose carrier of Klebsiella pneumoniae.

1992 • 26 citations

Structural basis of human erythrocyte glucose transporter function: pH effects on intrinsic fluorescence

1992 • 26 citations

The differential role of Cys‐421 and Cys‐429 of the Glut1 glucose transporter in transport inhibition by p‐chloromercuribenzenesulfonic acid (pCMBS) or cytochalasin B (CB)

1992 • 23 citations

Towards an understanding of the structural basis of ‘forbidden’ transport pathways in the Escherichia coli lactose carrier: mutations probing the energy barriers to uncoupled transport

1990 • 22 citations

Cytochalasin B interferes with conformational changes of the human erythrocyte glucose transporter induced by internal and external sugar binding

1991 • 21 citations

Sodium ion and proline binding sites in the Na+/proline symport carrier of Escherichia coli

1992 • 19 citations

Equilibrium and transient kinetic studies of the binding of cytochalasin B to the <scp>l</scp>‐arabinose–H⁺ symport protein of Escherichia coli

1993 • 16 citations

Ordered binding model as a general mechanistic mechanism for secondary active transport systems

1992 • 14 citations

Characterization of functional human erythrocyte-type glucose transporter (GLUT1) expressed in insect cells using a recombinant baculovirus

1992 • 14 citations

Deletion of C-terminal 12 amino acids of GLUT1 protein does not abolish the transport activity

1992 • 13 citations

An analysis of the side chain requirement at position 177 within the lactose permease which confers the ability to recognize maltose.

1992 • 11 citations

Chapter 6 Mechanisms of active and passive transport in a family of homologous sugar transporters found in both prokaryotes and eukaryotes

1992 • 10 citations

Initial steps of ?and ?-d-glucose binding to intact red cell membrane

1993 • 10 citations