Exercise: Is it a neuroprotective and if so, how does it work?

Neural consequences of enviromental enrichment

2000 • 2,376 citations

Exercise builds brain health: key roles of growth factor cascades and inflammation

2007 • 2,048 citations

Enriched environments, experience-dependent plasticity and disorders of the nervous system

2006 • 1,648 citations

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

2003 • 1,275 citations

MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE

2005 • 1,244 citations

The effectiveness of exercise interventions for people with Parkinson's disease: A systematic review and meta‐analysis

2008 • 875 citations

Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

1990 • 597 citations

Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man

1996 • 488 citations

Neurotrophic factors in Alzheimer’s and Parkinson’s disease brain

2000 • 486 citations

Neurotoxin-based models of Parkinson's disease

2011 • 478 citations

Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo

1994 • 453 citations

Physical activity and the risk of Parkinson disease

2005 • 357 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Presymptomatic compensation in Parkinson's disease is not dopamine-mediated

2003 • 340 citations

Physical activities and future risk of Parkinson disease

2010 • 300 citations

Exercise‐induced behavioral recovery and neuroplasticity in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐lesioned mouse basal ganglia

2004 • 298 citations

Environmental enrichment in adulthood eliminates neuronal death in experimental Parkinsonism

2004 • 236 citations

Enriched Environment Confers Resistance to 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine and Cocaine: Involvement of Dopamine Transporter and Trophic Factors

2003 • 209 citations

Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease

2013 • 151 citations

Enriched environment induces cellular plasticity in the adult substantia nigra and improves motor behavior function in the 6-OHDA rat model of Parkinson's disease

2006 • 123 citations

Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection

2006 • 119 citations

A partial GDNF depletion leads to earlier age-related deterioration of motor function and tyrosine hydroxylase expression in the substantia nigra

2006 • 107 citations

Exercise protects against MPTP-induced neurotoxicity in mice

2010 • 104 citations

Enriched environment improves motor function in intact and unilateral dopamine-depleted rats

2006 • 95 citations

Voluntary Running Provides Neuroprotection in Rats After 6-Hydroxydopamine Injection into the Medial Forebrain Bundle

2004 • 90 citations

Repetitive vibrissae-elicited forelimb placing before and immediately after unilateral 6-hydroxydopamine improves outcome in a model of Parkinson's disease

2007 • 46 citations

Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: Time course of protection and neurorestoration

2010 • 41 citations

Effect of sublethal 6‐hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning

2006 • 34 citations

Modification of Brain Circuits through Experience

2007 • 15 citations

Long-lasting transcriptional refractoriness triggered by a single exposure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine

2012 • 3 citations