Gastric H+, K+-adenosine triphosphatase β subunit is required for normal function, development, and membrane structure of mouse parietal cells

Physiology of the Gastrointestinal Tract

2006 • 4,704 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Structural organization, ion transport, and energy transduction of P-type ATPases

1996 • 738 citations

Processing and proliferative effects of human progastrin in transgenic mice.

1996 • 298 citations

Ultrastructural Changes in Oxyntic Cells Associated with Secretory Function: A Membrane-Recycling Hypothesis

1977 • 284 citations

Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

1998 • 249 citations

Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice

1997 • 238 citations

Impaired gastric acid secretion in gastrin-deficient mice

1998 • 206 citations

Diphtheria Toxin-mediated Ablation of Parietal Cells in the Stomach of Transgenic Mice

1996 • 204 citations

Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss

1993 • 197 citations

Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus.

1992 • 188 citations

The secretion-stimulated 80K phosphoprotein of parietal cells is ezrin, and has properties of a membrane cytoskeletal linker in the induced apical microvilli.

1991 • 182 citations

STUDIES ON THE DEPLETION AND ACCUMULATION OF MICROVILLI AND CHANGES IN THE TUBULOVESICULAR COMPARTMENT OF MOUSE PARIETAL CELLS IN RELATION TO GASTRIC ACID SECRETION

1974 • 176 citations

The potential of cryofixation and freeze substitution: observations and theoretical considerations

1991 • 164 citations

The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump).

1990 • 159 citations

Untersuchungen über den Bau der Labdrüsen

1870 • 145 citations

Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice.

1998 • 143 citations

Characterization of a beta subunit of the gastric H+/K(+)-transporting ATPase.

1990 • 142 citations

Membrane topology and omeprazole labeling of the gastric hydrogen ion-potassium-adenosinetriphosphatase

1993 • 135 citations

cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase.

1990 • 134 citations

Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit.

1996 • 131 citations

An ion-transporting ATPase encodes multiple apical localization signals.

1993 • 129 citations

The membrane-recruitment-and-recycling hypothesis of gastric HCl secretion

1996 • 111 citations

Genetic ablation of parietal cells in transgenic mice: a new model for analyzing cell lineage relationships in the gastric mucosa.

1996 • 107 citations

The H,K-ATPase beta-subunit can act as a surrogate for the beta-subunit of Na,K-pumps.

1991 • 101 citations

Membrane-cytoskeleton dynamics in rat parietal cells: mobilization of actin and spectrin upon stimulation of gastric acid secretion.

1989 • 100 citations

A Tyrosine-Based Signal Targets H/K-ATPase to a Regulated Compartment and Is Required for the Cessation of Gastric Acid Secretion

1997 • 98 citations

The Renal H-K-ATPase:Physiological Significance and Role in Potassium Homeostasis

1993 • 97 citations

Role of the transmembrane and extracytoplasmic domain of beta subunits in subunit assembly, intracellular transport, and functional expression of Na,K-pumps.

1993 • 83 citations

Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation

1989 • 80 citations

Poly-N-acetyllactosamine-specific tomato lectin interacts with gastric parietal cells Identification of a tomato-lectin binding 60-90×103/Mr membrane glycoprotein of tubuloveslcles

1990 • 75 citations

State of actin in gastric parietal cells

1998 • 68 citations

Multiple Members of a Third Subfamily of P-Type ATPases Identified by Genomic Sequences and ESTs

1998 • 63 citations

Inhibiting gastric H(+)-K(+)-ATPase activity by omeprazole promotes degeneration and production of parietal cells

1994 • 61 citations

Parietal cell autoantigens involved in neonatal thymectomy-induced murine autoimmune gastritis. Studies using monoclonal autoantibodies

1989 • 60 citations

The α-Subunit of the Colonic H+,K+-ATPase Assembles with β1-Na+,K+-ATPase in Kidney and Distal Colon

1998 • 57 citations

Expression and cellular localization of mRNA encoding the "gastric" isoform of H(+)-K(+)-ATPase alpha-subunit in rat kidney

1995 • 54 citations

The site of acid secretion in the mammalian parietal cell

1993 • 52 citations

The mouse gastric H,K-ATPase beta subunit. Gene structure and co-ordinate expression with the alpha subunit during ontogeny.

1992 • 49 citations

Fast freeze-fixation/freeze-substitution reveals the secretory membranes of the gastric parietal cell as a network of helically coiled tubule A new model for parietal cell transformation

1995 • 47 citations

Rapid purification of the gastric H+/K+-ATPase complex by tomato-lectin affinity chromatography

1992 • 47 citations

Site-directed antibodies as topographical probes of the gastric H,K-ATPase α-subunit

1992 • 41 citations

The Na+-K+-ATPase β1 subunit is associated with the HKα2 protein in the rat kidney

1998 • 36 citations

PROTON AND POTASSIUM TRANSPORT BY H⁺/K⁺‐ATPases

1995 • 36 citations

Gastrointestinal Hormones

1994 • 34 citations

From coiled tubules to a secretory canaliculus: a new model for membrane transformation and acid secretion by gastric parietal cells

1996 • 28 citations

The β-Subunit of the Rabbit H,K-ATPase: A Glycoprotein with All Terminal Lactosamine Units Capped with α-Linked Galactose Residues

1996 • 27 citations

Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit

1995 • 26 citations

Expression of gastric and colonic H(+)-K(+)-ATPase in the rat kidney

1995 • 26 citations

Structure and Function of Rat Parietal Cells during Treatment with Omeprazole, SCH 28080, SCH 32651, or Ranitidine

1990 • 22 citations

Monoclonal antibodies to the H+-K+ ATPase of gastric mucosa selectively stain the non-pigmented cells of the rabbit ciliary body epithelium.

1988 • 19 citations

Molecular evidence for a vascular smooth muscle H+-K+-ATPase

1997 • 14 citations

Deleted Work

1955 • 0 citations