Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Genomic sequencing.

1984 • 8,343 citations

Gastroduodenal mucosal protection

1993 • 483 citations

The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

1992 • 291 citations

NHE2 and NHE3 are human and rabbit intestinal brush-border proteins

1996 • 274 citations

Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger

1993 • 267 citations

Sodium/Hydrogen Exchanger Gene Defect in Slow-Wave Epilepsy Mutant Mice

1997 • 264 citations

Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

1994 • 257 citations

Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger

1993 • 221 citations

Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2)

1993 • 215 citations

Diphtheria Toxin-mediated Ablation of Parietal Cells in the Stomach of Transgenic Mice

1996 • 204 citations

Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss

1993 • 197 citations

Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

1997 • 154 citations

Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa

1994 • 152 citations

Digital image processing of intracellular pH in gastric oxyntic and chief cells

1987 • 145 citations

Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells.

1993 • 138 citations

Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa

1994 • 138 citations

Activation of the Avian Erythrocyte Na-K-Cl Cotransport Protein by Cell Shrinkage, cAMP, Fluoride, and Calyculin-A Involves Phosphorylation at Common Sites

1997 • 131 citations

Mucosal Microvascular Architecture of the Fundus and Body of Human Stomach

1984 • 99 citations

Na+/H+ exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells. Expression, functional localization, and differential regulation.

1994 • 98 citations

Effect of the Acid Secretory State on Intramural pH of Rabbit Gastric Mucosa

1978 • 97 citations

Electrolyte transport across the basolateral membrane of the parietal cells.

1985 • 94 citations

Three N-terminal Variants of the AE2 Cl-/HCO3- Exchanger Are Encoded by mRNAs Transcribed from Alternative Promoters

1996 • 93 citations

A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.

1994 • 90 citations

Activation of the Na+/H+ and Cl-/HCO3- exchange by stimulation of acid secretion in the parietal cell.

1988 • 82 citations

The microvascular architecture of the glandular mucosa of rat stomach.

1982 • 78 citations

Inhibiting gastric H(+)-K(+)-ATPase activity by omeprazole promotes degeneration and production of parietal cells

1994 • 61 citations

Secretory state of gastric mucosa and resistance to injury by exogenous acid

1977 • 59 citations

The relative importance of HCO3− and blood flow in the protection of rat gastric mucosa during shock

1981 • 54 citations

Role of basolateral Na(+)-K(+)-Cl- cotransport in HCl secretion by amphibian gastric mucosa

1995 • 39 citations

Gastrointestinal Hormones

1994 • 34 citations

Bicarbonate (HCO3) delivery to the gastroduodenal mucosa by the blood: its importance for mucosal integrity.

1988 • 34 citations

Na+/H+ exchange regulates intracellular pH of rat gastric surface cells in vivo

1992 • 27 citations

Effect of CO2 on pHi in rabbit parietal, chief, and surface cells

1989 • 24 citations

Different regulation by pHi and osmolarity of the rabbit ileum brush‐border and parietal cell basolateral anion exchanger.

1994 • 19 citations

Impaired gastric acid secretion in mast cell-deficient mice

1990 • 17 citations

Scanning electron microscopy of the stomach during modifications of acid secretion

1983 • 15 citations

Metabolic base production and mucosal vulnerability during acid inhibition in a mammalian stomachin vitro

1996 • 4 citations