The development of the vertebrate inner ear

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio

1996 • 1,633 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Functions of the neurotrophins during nervous system development: What the knockouts are teaching us

1994 • 1,431 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Pax-2 controls multiple steps of urogenital development

1995 • 865 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Neurotrophin receptors: A window into neuronal differentiation

1992 • 704 citations

Contributions of placodal and neural crest cells to avian cranial peripheral ganglia

1983 • 684 citations

SOX9 Binds DNA, Activates Transcription, and Coexpresses with Type II Collagen during Chondrogenesis in the Mouse

1997 • 665 citations

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

1991 • 664 citations

Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development

1995 • 662 citations

A human homologue of the Drosophila eyes absent gene underlies Branchio-Oto-Renal (BOR) syndrome and identifies a novel gene family

1997 • 660 citations

The Peripheral Nervous System

1974 • 630 citations

A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo.

1993 • 617 citations

Combinatorial expression of three zebrafish genes related to distal- less: part of a homeobox gene code for the head

1994 • 607 citations

Pax2 contributes to inner ear patterning and optic nerve trajectory

1996 • 588 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

Retinoic acid receptors and cellular retinoid binding proteins : II. Their differential pattern of transcription during early morphogenesis in mouse embryos

1991 • 527 citations

The drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system

1994 • 513 citations

Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development

1996 • 513 citations

Complementary roles of BDNF and NT-3 in vestibular and auditory development

1995 • 465 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis

1991 • 443 citations

Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function

1997 • 405 citations

Spatially and temporally restricted expression of Pax2 during murine neurogenesis

1990 • 397 citations

The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor

1994 • 391 citations

Two rhombomeres are altered in Hoxa-1 mutant mice

1993 • 391 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Thyroid hormone receptor β is essential for development of auditory function

1996 • 363 citations

Vitamin A-deficient quail embryos have half a hindbrain and other neural defects

1996 • 335 citations

MouseEyahomologues of theDrosophila eyes absentgene requirePax6for expression in lens and nasal placode

1997 • 333 citations

Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain

1996 • 332 citations

Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors

1983 • 327 citations

A Chick Homologue ofSerrateand Its Relationship withNotchandDeltaHomologues during Central Neurogenesis

1996 • 323 citations

Homeobox genes and connective tissue patterning

1995 • 321 citations

Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle

1995 • 317 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Mutations affecting development of the zebrafish inner ear and lateral line

1996 • 301 citations

Developmental expression of murine retinoid X receptor (RXR) genes

1994 • 297 citations

Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia.

1992 • 293 citations

Inductive Processes in Embryonic Development

1966 • 287 citations

Cloning and characterization of two members of the vertebrate Dlx gene family.

1994 • 276 citations

Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development

1995 • 270 citations

Expression of FGF receptor gene in rat development

1991 • 264 citations

Wnt expression patterns in chick embryo nervous system

1995 • 260 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system

1996 • 236 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development

1994 • 227 citations

Expression of two zebrafish orthodenticle-related genes in the embryonic brain

1994 • 227 citations

A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

1992 • 226 citations

Retinoic acid and pattern formation in vertebrates

1995 • 223 citations

Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals

1993 • 215 citations

The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

1993 • 209 citations

Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivo.

1994 • 207 citations

The role of neurotrophic factors in regulating the development of inner ear innervation

1997 • 206 citations

Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis

1992 • 201 citations

Sensory Organ Generation in the Chick Inner Ear

1996 • 198 citations

New hair cells arise from supporting cell conversion in the acoustically damaged chick inner ear

1996 • 190 citations

The kreisler mouse: a hindbrain segmentation mutant that lacks tworhombomeres

1994 • 184 citations

The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture

1993 • 183 citations

Fibroblast growth factors in mammalian development

1995 • 182 citations

The int-2 proto-oncogene is responsible for induction of the inner ear

1991 • 181 citations

Multiple roles for FGF-3 during cranial neural development in the chicken

1995 • 176 citations

On the development of the membranous labyrinth and the acoustic and facial nerves in the human embryo

1906 • 174 citations

Cell fate specification in the inner ear

1996 • 173 citations

Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos

1992 • 171 citations

The biology of change in otolaryngology

1988 • 165 citations

Differential Expression of Bone Morphogenetic Proteins in the Developing Vestibular and Auditory Sensory Organs

1996 • 162 citations

Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear

1994 • 159 citations

INHERITED HEARING DEFECTS IN MICE

1995 • 157 citations

The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus development

1995 • 146 citations

Segmental regulation of Hoxb-3 by kreisler

1997 • 145 citations

Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)

1993 • 144 citations

Regenerative Proliferation in Organ Cultures of the Avian Cochlea: Identification of the Initial Progenitors and Determination of the Latency of the Proliferative Response

1996 • 138 citations

Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by mesodermal and neural induction

1992 • 136 citations

Nkx5-1 controls semicircular canal formation in the mouse inner ear

1998 • 130 citations

The determination and positioning of the nose, lens and ear. I. Interactions within the ectoderm, and between the ectoderm and underlying tissues

1963 • 126 citations

Induction of chondrogenesis: requirement for synergistic interaction of basic fibroblast growth factor and transforming growth factor-beta

1994 • 121 citations

Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons

1995 • 121 citations

Developing inner ear sensory neurons require TrkB and TrkC receptors for innervation of their peripheral targets

1995 • 121 citations

Epithelial autonomy in the development of the inner ear of a bird embryo

1990 • 116 citations

An analysis of induction of the ear from foreign ectoderm in the salamander embryo

1950 • 111 citations

Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat

1991 • 109 citations

Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene.

1997 • 105 citations

The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant

1997 • 104 citations

Repating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken

1991 • 99 citations

The fate mapping of the eleventh and twelfth day mouse otocyst: An in vitro study of the sites of origin of the embryonic inner ear sensory structures

1978 • 98 citations

Genes and deafness

1994 • 98 citations

Brain-Derived Neurotrophic Factor and Neurotrophin-3 Support the Survival and Neuritogenesis Response of Developing Cochleovestibular Ganglion Neurons

1993 • 98 citations

Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL/6N mouse embryo

1995 • 97 citations

Xotx genes in the developing brain of Xenopus laevis

1996 • 96 citations

Expression of cell adhesion molecules during embryonic induction

1987 • 94 citations

Inductive Processes Leading to Inner Ear Formation duringXenopusDevelopment

1996 • 92 citations

Hair cell differentiation in chick cochlear epithelium after aminoglycoside toxicity: in vivo and in vitro observations.

1996 • 89 citations

Embryonic Development of Vestibular Sense Organs and Their Innervation11Research supported by the Swedish Medical Research Council, Project 12X-720.

1983 • 86 citations

Cellular Localization of Brain‐derived Neurotrophic Factor and Neurotrophin‐3 mRNA Expression in the Early Chicken Embryo

1993 • 83 citations

Integrin α6 expression is required for early nervous system development in Xenopus laevis

1996 • 82 citations

Asymmetric expression of a novel homeobox gene in vertebrate sensory organs

1994 • 79 citations

The Determination of the Auditory Placode in the Chick

1937 • 79 citations

A Xenopus distal-less gene in transgenic mice: conserved regulation in distal limb epidermis and other sites of epithelial-mesenchymal interaction.

1995 • 78 citations

Experiments on the determination of the ear ectoderm in the embryo of Amblystoma punctatum

1933 • 77 citations

Differential expression of a Distal-less homeobox gene Xdll-2 in ectodermal cell lineages

1994 • 76 citations

The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures

1996 • 75 citations

Hair Cell Differentiation in Chick Cochlear Epithelium after Aminoglycoside Toxicity:In VivoandIn VitroObservations

1996 • 72 citations

Insulin-like growth factor-I regulates cell proliferation in the developing inner ear, activating glycosyl-phosphatidylinositol hydrolysis and Fos expression.

1995 • 69 citations

Distinct temporal expression of mouse Nkx-5.1 and Nkx-5.2 homeo☐ genes during brain and ear development

1995 • 66 citations

Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development

1996 • 65 citations

Characterization of the Homeobox-Containing Gene GH6 Identifies Novel Regions of Homeobox Gene Expression in the Developing Chick Embryo

1994 • 64 citations

Influence of the Neural Tube on the Differentiation of the Inner Ear in the Mammalian Embryo

1966 • 62 citations

Retinoic acid modulation of the early development of the inner ear is associated with the control of c-fos expression

1990 • 59 citations

Bombesin and other growth factors activate cell proliferation in chick embryo otic vesicles in culture

1988 • 58 citations

Spatially restricted expression of fibroblast growth factor receptor-2 during Xenopus development

1992 • 57 citations

Hair and supporting‐cell differentiation during the development of the avian inner ear

1995 • 56 citations

Parathyroid hormone related peptide mRNA expression during murine postimplantation development: evidence for involvement in multiple differentiation processes.

1996 • 54 citations

Effects of the Neurotrophins and CNTF on Developing Statoacoustic Neurons: Comparison with an Otocyst-Derived Factor

1993 • 53 citations

Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor.

1991 • 53 citations

Molecular cloning and cellular localization of trk C in the chicken embryo

1993 • 52 citations

Pattern of trkB protein-like immunoreactivity in vivo and the in vitro effects of brain-derived neurotrophic factor (BDNF) on developing cochlear and vestibular neurons

1994 • 49 citations

Appearance of Glucocorticoid Receptors in the Inner Ear of the Mouse during Development

1996 • 43 citations

Brain-Derived Neurotrophic Factor and Neurotrophin-3 Induce Cell Proliferation in the Cochleovestibular Ganglion through a Glycosyl-Phosphatidylinositol Signaling System

1993 • 41 citations

Tropic effects of otic epithelium on cochleo‐vestibular ganglion fiber growth in vitro

1992 • 40 citations

Expression of genes encoding the collagen-binding heat shock protein (Hsp47) and type II collagen in developing zebrafish embryos

1997 • 38 citations

The LIM homeodomain protein Lim-1 is widely expressed in neural, neural crest and mesoderm derivatives in vertebrate development.

1996 • 38 citations

Heterotopic transplantation of presumptive placodal ectoderm changes the fate of sensory neuron precursors

1993 • 36 citations

Basic Fibroblast Growth Factor Affects Neuronal Migration and Differentiation in Normotypic Cell Cultures from the Cochleovestibular Ganglion of the Chick Embryo

1996 • 35 citations

Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3

1997 • 31 citations

Ventral neural cadherin, a novel cadherin expressed in a subset of neural tissues in the zebrafish embryo

1996 • 23 citations

Inositol phospho-oligosaccharide stimulates cell proliferation in the early developing inner ear

1991 • 20 citations

Localization ofbcl-2, bax, andbcl-x mRNAs in the developing inner ear of the mouse

1996 • 20 citations

Developmental Regulation of Fos-Protein during Proliferative Growth of the Otic Vesicle and its Relation to Differentiation Induced by Retinoic Acid

1995 • 20 citations

Cloning and expression studies of cDNA for a novelXenopus cadherin (XmN-cadherin), expressed maternally and later neural-specifically in embryogenesis

1996 • 19 citations

Hair cell development

1993 • 19 citations

Limb deformity proteins during avian neurulation and sense organ development

1995 • 16 citations

Cloning and expression of genes coding for protein kinase CK2 alpha and beta subunits in zebrafish (Danio rerio).

1994 • 8 citations

Glutamate receptors in the developing cochlear ganglion.

1996 • 5 citations

Int-2 Influences the Development of the Nodose Ganglion

1995 • 4 citations

Using herpes simplex virus type 1 (HSV-1) mediated gene transfer to study neurotrophins in cochlear neurons.

1996 • 1 citations