Retinoic acid and pattern formation in vertebrates

Homeobox genes and axial patterning

1992 • 2,688 citations

Sonic hedgehog mediates the polarizing activity of the ZPA

1993 • 2,313 citations

Hox genes in vertebrate development

1994 • 2,057 citations

The retinoids—Biology, chemistry and medicine

1996 • 1,192 citations

Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos

1992 • 1,176 citations

Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes

1994 • 1,114 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Function of the retinoic acid receptors (RARs) during development: (II) Multiple abnormalities at various stages of organogenesis in RAR double mutants

1994 • 987 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1994 • 801 citations

Nested expression domains of four homeobox genes in developing rostral brain

1992 • 794 citations

Function of the retinoic acid receptors (RARs) during development: (I) Craniofacial and skeletal abnormalities in RAR double mutants

1994 • 755 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

A positive feedback loop coordinates growth and patterning in the vertebrate limb

1994 • 702 citations

Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis

1994 • 684 citations

RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.

1994 • 632 citations

Positional signalling and specification of digits in chick limb morphogenesis

1975 • 588 citations

Exogenous retinoic acid rapidly induces anterior ectopic expression of murine Hox-2 genes in vivo

1992 • 467 citations

Retinoic acid alters hindbrain Hox code and induces transformation of rhombomeres 2/3 into a 4/5 identity

1992 • 461 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development

1991 • 410 citations

The retinoids; Biology, chemistry, and medicine

1994 • 400 citations

Identification of a retinoic acid-sensitive period during primary axis formation in Xenopus laevis.

1990 • 364 citations

Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants

1994 • 333 citations

Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm

1990 • 300 citations

Polarizing activity and retinoid synthesis in the floor plate of the neural tube

1990 • 292 citations

Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6

1992 • 268 citations

Developmental analysis of the retinoic acid-inducible RAR-βJ2 promoter in transgenic animals

1991 • 258 citations

Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay

1992 • 250 citations

Effects of retinoic acid excess on expression of Hox-2.9 and Krox-20 and on morphological segmentation in the hindbrain of mouse embryos.

1991 • 247 citations

Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud

1991 • 242 citations

Expression of the mouse labial-Alike homeobox-containing genes, Hox 2.9 and Hox 1.6, during segmentation of the hindbrain

1991 • 239 citations

Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud

1991 • 218 citations

Evidence that Hensen's node is a site of retinoic acid synthesis

1992 • 216 citations

Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos

1991 • 204 citations

Retinoic acid modifies development of the midbrain-hindbrain border and affects cranial ganglion formation in zebrafish embryos

1991 • 188 citations

Activation and organization of the central nervous system in amphibians. Part III. Synthesis of a new working hypothesis

1952 • 180 citations

EctopicHoxa-1induces rhombomere transformation in mouse hindbrain

1994 • 166 citations

Size dependence during the development of the amphibian foot. Colchicine-induced digital loss and reduction

1983 • 163 citations

An early marker of axial pattern in the chick embryo and its respecification by retinoic acid

1992 • 142 citations

Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.

1993 • 139 citations

Emx and Otx homeobox genes in the developing mouse brain

1993 • 139 citations

If birds can fly, why can't we? Homeotic genes and evolution

1994 • 107 citations

Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3′ HoxB gene expression domains

1994 • 80 citations

Activity of the β-retinoic acid receptor promoter in transgenic mice

1991 • 74 citations

The control of growth and the development of pattern across the anteroposterior axis of the chick limb bud

1981 • 36 citations

Retinoids for the future: Investigational approaches for the identification of new compounds

1992 • 19 citations