The nucleoskeleton and the topology of replication

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

Control of proliferation in animal cells

1974 • 1,177 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

1983 • 630 citations

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

1986 • 622 citations

Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA

1987 • 550 citations

Metaphase chromosome structure

1986 • 538 citations

Mapping replicational sites in the eucaryotic cell nucleus.

1989 • 520 citations

Nuclear Protein Matrix: Association with Newly Synthesized DNA

1975 • 487 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

1984 • 444 citations

Core filaments of the nuclear matrix.

1990 • 436 citations

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1986 • 436 citations

Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin

1990 • 430 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

Chromosome assembly in vitro: Topoisomerase II is required for condensation

1991 • 382 citations

A cell free system to study reassembly of the nuclear envelope at the end of mitosis

1986 • 382 citations

THE ROLE OF THE NUCLEAR MATRIX IN THE ORGANIZATION AND FUNCTION OF DNA

1986 • 360 citations

Replication of simian virus 40 origin-containing DNA in vitro with purified proteins.

1987 • 355 citations

Arrest of segregation leads to accumulation of highly intertwined catenated dimers: Dissection of the final stages of SV40 DNA replication

1981 • 354 citations

Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers

1980 • 351 citations

Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes

1987 • 349 citations

Complete enzymatic synthesis of DNA containing the SV40 origin of replication.

1988 • 297 citations

Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis

1986 • 292 citations

The in vitro replication of DNA containing the SV40 origin.

1990 • 268 citations

Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers.

1990 • 255 citations

The size of chromatin loops in HeLa cells.

1990 • 246 citations

Replication occurs at a nucleoskeleton.

1986 • 230 citations

The nuclear matrix: Structure and composition

1988 • 220 citations

Visualization of a filamentous nucleoskeleton with a 23 nm axial repeat.

1988 • 216 citations

DNA is replicated at the nuclear cage

1980 • 210 citations

Replication occurs at discrete foci spaced throughout nuclei replicating in vitro

1989 • 192 citations

Mitotic chromatin condensation in vitro using somatic cell extracts and nuclei with variable levels of endogenous topoisomerase II.

1990 • 181 citations

Matrix attachment regions are positioned near replication initiation sites, genes, and an interamplicon junction in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells.

1988 • 177 citations

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1989 • 174 citations

Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion

1979 • 170 citations

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

1985 • 168 citations

A general method for preparing chromatin containing intact DNA.

1985 • 161 citations

A gentle method for preparing cyto- and nucleo-skeletons and associated chromatin

1988 • 155 citations

The nucleoskeleton: Artefact, passive framework or active site?

1988 • 143 citations

New beginnings in studies of eukaryotic DNA replication origins

1989 • 139 citations

Structure–function relationships in eukaryotic nuclei

1991 • 138 citations

Bidirectional chromosome replication: Some topological considerations

1974 • 128 citations

Periodic DNA synthesis in cell-free extracts of Xenopus eggs.

1987 • 127 citations

The nucleoskeleton and the topology of transcription

1989 • 110 citations

The Structure of Sister Minichromosome DNA Before Anaphase in Saccharomyces Cerevisiae

1987 • 104 citations

The control of DNA replication in a cell-free extract that recapitulates a basic cell cycle in vitro

1988 • 91 citations

Swiveling and decatenation of replicating simian virus 40 genomes in vivo.

1988 • 90 citations

Helical Repeat and Linking Number of Surface-Wrapped DNA

1988 • 86 citations

Identification of 100 and 150 S DNA polymerase alpha-primase megacomplexes solubilized from the nuclear matrix of regenerating rat liver.

1987 • 86 citations

THE SPIRAL STRUCTURE OF CHROMOSOMES

1950 • 74 citations

The two faces of higher eukaryotic DNA replication origins

1990 • 73 citations

A cell-cycle-dependent DNA polymerase activity that replicates intact DNA in chromatin

1986 • 66 citations

Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replicationin vivo

1987 • 61 citations

Supercoiled loop organization of genomic DNA: A close relationship between loop domains, expression units, and replicon organization in rDNA from Xenopus laevis

1989 • 52 citations

Molecular mechanism in the formation of a human ring chromosome 21.

1989 • 51 citations

Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication

1990 • 47 citations

Different populations of DNA polymerase α in HeLa cells

1986 • 45 citations

Template supercoiling during ATP-dependent DNA helix tracking: studies with simian virus 40 large tumor antigen.

1989 • 42 citations

Resinless section immunogold electron microscopy of karyo-cytoskeletal frameworks of eukaryotic cells cultured in vitro: Absence of a salt-stable nuclear matrix from mouse plasmacytoma MPC-11 cells

1991 • 40 citations

What the papers say: The organization of replication centres in higher eukaryotes

1990 • 38 citations

The Ultrastructural Organization of Prematurely Condensed Chromosomes

1984 • 26 citations

Temperature-dependent association of DNA polymerase α activity with the nuclear matrix

1990 • 24 citations

Comments on Chromosome Structure

1945 • 11 citations

LAMPBRUSH CHROMOSOMES

1977 • 9 citations

Enzyme systems initiating replication at the origin of the ESCHERICHIA COLI chromosome

1987 • 9 citations

Recipes for replication

1990 • 6 citations

Putting a twist in the tale

1990 • 4 citations