Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can functionas an enhancer element in Drosophila

Homeobox genes and axial patterning

1992 • 2,688 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

1991 • 538 citations

Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules

1994 • 506 citations

The sequence specificity of homeodomain-DNA interaction

1988 • 501 citations

Characterization and localization of the even-skipped protein of Drosophila.

1987 • 496 citations

Divergent homeo box proteins recognize similar DNA sequences in Drosophila

1988 • 491 citations

Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution.

1990 • 460 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

Redesigning the body plan of Drosophila by ectopic expression of the homoeotic gene Antennapedia

1987 • 391 citations

Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.

1994 • 364 citations

Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes

1995 • 350 citations

Expression of the caudal gene in the germ line of Drosophila: Formation of an RNA and protein gradient during early embryogenesis

1987 • 282 citations

Determination of the Nuclear Magnetic Resonance Solution Structure of an Antennapedia Homeodomain-DNA Complex

1993 • 270 citations

Functional dissection of ultrabithorax proteins in D. melanogaster

1990 • 255 citations

Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila

1984 • 244 citations

Human Hox-4.2 and Drosophila Deformed encode similar regulatory specificities in Drosophila embryos and larvae

1990 • 225 citations

Isolation and sequence-specific DNA binding of the Antennapedia homeodomain.

1988 • 221 citations

Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells

1985 • 209 citations

Activation of posterior gap gene expression in the Drosophila blastoderm

1995 • 201 citations

DNA binding properties of the purified Antennapedia homeodomain.

1990 • 193 citations

The specificities of sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain

1990 • 189 citations

The localization and regulation of Antennapedia protein expression in Drosophila embryos

1986 • 186 citations

The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila

1986 • 186 citations

Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila.

1991 • 184 citations

Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae

1990 • 182 citations

Direct homeodomain–DNA interaction in the autoregulation of the fushi tarazu gene

1992 • 179 citations

Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion

1988 • 178 citations

An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters

1988 • 166 citations

Head and thoracic transformations caused by ectopic expression ofAntennapediaduringDrosophiladevelopment

1988 • 147 citations

Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.

1992 • 146 citations

Mapping functional specificity in the Dfd and Ubx homeo domains.

1992 • 134 citations

The caudal gene product is a direct activator of fushi tarazu transcription during Drosophila embryogenesis

1989 • 133 citations

Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated.

1990 • 118 citations

The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.

1993 • 116 citations

Cloning of integrated Moloney sarcoma proviral DNA sequences in bacteriophage lambda.

1979 • 114 citations

Primary structure and nuclear localization of a murine homeodomain protein.

1987 • 112 citations

The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences.

1993 • 112 citations

Separate elements cause lineage restriction and specify boundaries of Hox-1·1 expression

1991 • 105 citations

The mouse Hox-1.4 gene: primary structure, evidence for promoter activity and expression during development

1989 • 100 citations

A human HOX4B regulatory element provides head-specific expression in Drosophila embryos

1992 • 100 citations

High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.

1991 • 99 citations

An autoregulatory enhancer element of the Drosophila homeotic gene Deformed.

1990 • 96 citations

Differential regulation of Ultrabithorax in two germ layers of drosophila

1988 • 92 citations

Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.

1995 • 84 citations

Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes.

1994 • 78 citations

Effects of ectopic expression of caudal during Drosophila development

1990 • 77 citations

Nuclear Magnetic Resonance Spectroscopy of a DNA Complex with the Uniformly 13C-Labeled Antennapedia Homeodomain and Structure Determination of the DNA-bound Homeodomain

1993 • 72 citations

Conserved sequence elements in the 5′ region of the Ultrabithorax transcription unit

1987 • 72 citations

Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice

1992 • 71 citations

The regulation of empty spiracles by Abdominal-B mediates an abdominal segment identity function.

1993 • 71 citations

Position-specific activity of the Hox1.1 promoter in transgenic mice

1990 • 69 citations

Position-specific activity of the Hox 1.1 promoter in transgenic mice

1990 • 67 citations

A conserved enhancer of the human and murine Hoxa-7 gene specifies the anterior boundary of expression during embryonal development

1995 • 63 citations

Comparative analysis of chicken Hoxb-4 regulation in transgenic mice

1995 • 55 citations

Analysis of a fushi tarazu autoregulatory element: multiple sequence elements contribute to enhancer activity.

1993 • 55 citations

Altering the regulatory targets of the Deformed protein in Drosophila embryos by substituting the Abdominal-B homeodomain

1990 • 48 citations

Molecular mechanisms underlying the expression of the human HOX-5.1 gene

1990 • 47 citations

Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm.

1989 • 43 citations

Multiple proteins interact with the fushi tarazu proximal enhancer.

1993 • 40 citations

The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.

1994 • 21 citations

Multiple Proteins Interact with the fushi tarazu Proximal Enhancer†

1993 • 14 citations