Pharmacodynamics and pharmacokinetics of antibiotics with special reference to the fluoroquinolones

Antibiotics in Laboratory Medicine.

1980 • 2,763 citations

The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro

1985 • 694 citations

Fluoroquinolone antimicrobial agents

1989 • 633 citations

Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

1987 • 486 citations

Antibiotics in laboratory medicine

1986 • 332 citations

Killing and regrowth of bacteria in vitro: a review.

1990 • 301 citations

Evaluation of Intravenous Ciprofloxacin in Patients With Nosocomial Lower Respiratory Tract Infections

1989 • 169 citations

Clinical Pharmacokinetics of the Newer Antibacterial 4-Quinolones

1988 • 140 citations

Comparative dose-effect relations at several dosing intervals for beta-lactam, aminoglycoside and quinolone antibiotics against gram-negative bacilli in murine thigh-infection and pneumonitis models.

1990 • 135 citations

Effect of Salt Concentration on the Apparent In-Vitro Susceptibility of Pseudomonas and Other Gram-Negative Bacilli to Gentamicin

1971 • 132 citations

The mode of action of 4-quinolones and possible mechanisms of resistance

1986 • 123 citations

The postantibiotic effect

1986 • 117 citations

Interactions of Fluoroquinolones with Other Drugs: Mechanisms, Variability, Clinical Significance, and Management

1992 • 113 citations

Selection of Aminoglycoside-Resistant Variants of Pseudomonas aeruginosa in an in Vivo Model

1982 • 109 citations

Human pharmacodynamics of beta-lactams, aminoglycosides and their combination.

1990 • 86 citations

Correlation of pharmacokinetic parameters to efficacy of antibiotics: relationships between serum concentrations, MIC values, and bacterial eradication in patients with gram-negative pneumonia.

1990 • 78 citations

Occult Aminoglycoside Resistance in Pseudomonas aeruginosa: Epidemiology and Implications for Therapy and Control

1985 • 67 citations

The Importance of Pharmacodynamics in Determining the Dosing Interval in Therapy for Experimental Pseudomonas Endocarditis in the Rat

1986 • 56 citations

Pulse Dosing Versus Continuous Infusion of Antibiotics

1988 • 49 citations

Combination Therapy with Ciprofloxacin plus Azlocillin against Pseudomonas aeruginosa: Effect of Simultaneous versus Staggered Administration in an In Vitro Model of Infection

1991 • 46 citations

Comparative study on antagonistic effects of low pH and cation supplementation on in-vitro activity of quinolones and aminoglycosides against Pseudomonas aeruginosa

1988 • 42 citations

Influence of medium and method on the in vitro susceptibility of Pseudomonas aeruginosa and other bacteria to ciprofloxacin and enoxacin

1986 • 31 citations

Efficacy of ciprofloxacin in stationary-phase bacteria in vivo.

1987 • 27 citations

Single daily dosing of amikacin in an in-vitro model

1991 • 24 citations

Effect of dose and schedule on cefoperazone pharmacodynamics in an in Vitro model of infection in a neutropenic host

1988 • 21 citations

Impact of the antibiotic dosage schedule on efficacy in experimental lung infections.

1990 • 16 citations

A review of the pharmacokinetic profile of temafloxacin

1991 • 11 citations

Abhängigkeit von Bakterizidie und Mutantenselektion bei 4-Chinolonen von deren Serumkonzentrationsverläufen

1986 • 9 citations