Combination Therapy with Ciprofloxacin plus Azlocillin against Pseudomonas aeruginosa: Effect of Simultaneous versus Staggered Administration in an In Vitro Model of Infection

Comparative study with enoxacin and netilmicin in a pharmacodynamic model to determine importance of ratio of antibiotic peak concentration to MIC for bactericidal activity and emergence of resistance

1987 • 486 citations

Peritz' F test: Basic program of a robust multiple comparison test for statistical analysis of all differences among group means

1984 • 305 citations

Two compartment kinetic model with multiple artificial capillary units

1985 • 113 citations

Bacterial Resistance to Quinolones: Mechanisms and Clinical Importance

1989 • 109 citations

Resistance occurring after fluoroquinolone therapy of experimental Pseudomonas aeruginosa peritonitis

1987 • 104 citations

Ciprofloxacin therapy of infections caused by Pseudomonas aeruginosa and other resistant bacteria

1985 • 79 citations

Pharmacodynamic Properties of Antibiotics: Application to Drug Monitoring and Dosage Regimen Design

1990 • 77 citations

Ciprofloxacin therapy in cystic fibrosis.

1987 • 75 citations

The new quinolones and their combinations with other agents for therapy of severe infections

1986 • 70 citations

Synergy of Fluoroquinolones with Other Antimicrobial Agents

1989 • 65 citations

Combination therapy: a way to limit emergence of resistance?

1986 • 60 citations

Ciprofloxacin, azlocilin, ceftizoxime and amikacin alone and in combination against Gram-negative bacilli in an infected chamber model

1986 • 52 citations

Emergence of resistance after therapy with antibiotics used alone or combined in a marine model

1986 • 49 citations

Combination antibiotic therapy: comparison of constant infusion and intermittent bolus dosing in an experimental animal model

1985 • 47 citations

Comparative evaluation of ciprofloxacin, enoxacin, and ofloxacin in experimental Pseudomonas aeruginosa pneumonia

1986 • 47 citations

Synergy of ciprofloxacin and azlocillin in vitro and in a neutropenic mouse model of infection

1986 • 46 citations

Ciprofloxacin in combination with other antimicrobials

1989 • 31 citations

Effect of dose on serum pharmacokinetics of intravenous ciprofloxacin with identification and characterization of extravascular compartments using noncompartmental and compartmental pharmacokinetic models

1987 • 31 citations

Influence of medium and method on the in vitro susceptibility of Pseudomonas aeruginosa and other bacteria to ciprofloxacin and enoxacin

1986 • 31 citations

Pharmacodynamic effects of subinhibitory antibiotic concentrations.

1990 • 28 citations

Fluoroquinolones in the treatment of infectious diseases

1990 • 27 citations

Antipseudomonal activity of simulated infusions of gentamicin alone or with piperacillin assessed by serum bactericidal rate and area under the killing curve

1989 • 21 citations

Interactions of antimicrobial combinations in vitro: the relativity of synergism.

1990 • 19 citations

Comparative Efficacy of Ciprofloxacin, Azlocillin, and Tobramycin Alone and in Combination in Experimental Pseudomonas Sepsis

1987 • 15 citations

Interactions of the 4-quinolones with other antibacterials

1989 • 15 citations

Review of the pharmacokinetics and dose dependency of azlocillin in normal subjects and patients with renal insufficiency

1983 • 14 citations

Efficacy of ciprofloxacin alone and in combination with azlocillin in experimental endocarditis due to pseudomonas aeruginosa

1989 • 10 citations

Evaluation of ciprofloxacin alone and in combination with other antibiotics in a murine model of thigh muscle infection.

1987 • 8 citations

Combined action of decreasing concentrations of azlocillin and sisomicin on pseudomonas aeruginosa as assessed in a dynamic in vitro model

1982 • 8 citations

Serum bactericidal activity from intravenous ciprofloxacin and azlocillin given alone and in combination to healthy subjects

1990 • 6 citations

Serum Inhibitory and Bactericidal Activity of Ciprofloxacin following Intravenous Administration

1989 • 2 citations

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