MR microscopy and high resolution small animal MRI: applications in neuroscience research

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields

1990 • 2,225 citations

Early detection of regional cerebral ischemia in cats: Comparison of diffusion‐ and T2‐weighted MRI and spectroscopy

1990 • 1,629 citations

In vivo magnetic resonance imaging of transgene expression

2000 • 785 citations

Diffusion Magnetic Resonance Imaging: an Early Surrogate Marker of Therapeutic Efficacy in Brain Tumors

2000 • 677 citations

Atlas of the Mouse Brain and Spinal Cord

1971 • 582 citations

Effect of Formalin Tissue Fixation and Processing on Immunohistochemistry

2000 • 571 citations

Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination

1999 • 539 citations

Nmr Imaging in Biomedicine

1982 • 516 citations

Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.

1992 • 515 citations

Comparison of diffusion‐ and T2‐weighted MRI for the early detection of cerebral ischemia and reperfusion in rats

1991 • 507 citations

Gene therapy of experimental brain tumors using neural progenitor cells

2000 • 459 citations

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

1999 • 457 citations

In vivo neuronal tract tracing using manganese‐enhanced magnetic resonance imaging

1998 • 447 citations

Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging.

1997 • 412 citations

In vivo three-dimensional reconstruction of rat brain axonal projections by diffusion tensor imaging

1999 • 393 citations

Contribution of vasogenic and cellular edema to traumatic brain swelling measured by diffusion-weighted imaging

1997 • 370 citations

Tumoral Distribution of Long-circulating Dextran-coated Iron Oxide Nanoparticles in a Rodent Model

2000 • 349 citations

Diffusion-weighted imaging studies of cerebral ischemia in gerbils. Potential relevance to energy failure.

1992 • 317 citations

Diffusion‐weighted magnetic resonance imaging

1992 • 302 citations

A Reproducible Model of Middle Cerebral Artery Occlusion in Mice: Hemodynamic, Biochemical, and Magnetic Resonance Imaging

1998 • 282 citations

Potassium-Induced Cortical Spreading Depressions during Focal Cerebral Ischemia in Rats: Contribution to Lesion Growth Assessed by Diffusion-Weighted NMR and Biochemical Imaging

1996 • 277 citations

Magnetic resonance imaging assessment of evolving focal cerebral ischemia. Comparison with histopathology in rats.

1994 • 262 citations

Diffusion tensor imaging of the developing mouse brain

2001 • 245 citations

Work in progress: methods of contrast enhancement for NMR imaging and potential applications. A subject review.

1983 • 235 citations

A Model to Predict the Histopathology of Human Stroke Using Diffusion and T2-Weighted Magnetic Resonance Imaging

1995 • 220 citations

The effects of microscopic tissue parameters on the diffusion weighted magnetic resonance imaging experiment

2001 • 216 citations

Histology by magnetic resonance microscopy.

1993 • 212 citations

A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice.

2001 • 211 citations

Temporal evolution of ischemic damage in rat brain measured by proton nuclear magnetic resonance imaging.

1991 • 206 citations

Three-Dimensional Digital Mouse Atlas Using High-Resolution MRI

2001 • 206 citations

Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange

2000 • 200 citations

New directions in the development of MR imaging contrast media.

1992 • 195 citations

Determination of the MRI contrast agent concentration time course in vivo following bolus injection: Effect of equilibrium transcytolemmal water exchange

2000 • 191 citations

Nervous System Defects of AnkyrinB (−/−) Mice Suggest Functional Overlap between the Cell Adhesion Molecule L1 and 440-kD AnkyrinB in Premyelinated Axons

1998 • 187 citations

Acute and chronic changes of the apparent diffusion coefficient in neurological disorders—biophysical mechanisms and possible underlying histopathology

2001 • 176 citations

Rapid monitoring of changes in water diffusion coefficients during reversible ischemia in cat and rat brain

1994 • 175 citations

Magnetic resonance microscopy of mouse embryos.

1994 • 169 citations

Cocaine Activation Discriminates Dopaminergic Projections by Temporal Response: An fMRI Study in Rat

2000 • 164 citations

Spatially Resolved Magnetic Resonance

1998 • 153 citations

Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin‐labeled MRI

2001 • 153 citations

ICAM-1 expression in autoimmune encephalitis visualized using magnetic resonance imaging

2000 • 142 citations

Comparison of diffusion‐weighted MRI with changes in cell volume in a rat model of brain injury

1994 • 140 citations

Calcium antagonists reduce the extent of infarction in rat middle cerebral artery occlusion model as determined by quantitative magnetic resonance imaging.

1986 • 140 citations

Nuclear magnetic resonance imaging of the abnormal live rat and correlations with tissue characteristics.

1981 • 137 citations

Spreading waves of decreased diffusion coefficient lifter cortical stimulation in the rat brain

1994 • 136 citations

Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI

1999 • 130 citations

MR Detection of Cortical Spreading Depression Immediately after Focal Ischemia in the Rat

1996 • 129 citations

Activation of single whisker barrel in rat brain localized by functional magnetic resonance imaging.

1996 • 129 citations

Visualization of neural tissue water compartments using biexponential diffusion tensor MRI

2001 • 128 citations

Measurements of T1 and T2 over time in formalin-fixed human whole-brain specimens

1992 • 122 citations

Nuclear Magnetic Resonance Technology for Medical Studies

1984 • 122 citations

High resolution quantitative relaxation and diffusion mri of three different experimental brain tumors in rat

1995 • 121 citations

Nuclear magnetic resonance relaxation in experimental brain edema: Effects of water concentration, protein concentration, and temperature

1988 • 119 citations

Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain

1995 • 118 citations

Polymeric Contrast Agents for Medical Imaging

2000 • 117 citations

Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema

2001 • 116 citations

Variation of functional MRI signal in response to frequency of somatosensory stimulation in α‐chloralose anesthetized rats

1996 • 112 citations

Imaging brain activity in conscious animals using functional MRI

1998 • 111 citations

Diffusion-weighted imaging differentiates ischemic tissue from traumatized tissue.

1994 • 111 citations

Field Focusing Nuclear Magnetic Resonance (FONAR): Visualization of a Tumor in a Live Animal

1976 • 109 citations

Relaxation-Time and Diffusion NMR Microscopy of Single Neurons

1994 • 105 citations

Nuclear magnetic resonance imaging at microscopic resolution

1986 • 103 citations

Characterization of Experimental Ischemic Brain Edema Utilizing Proton Nuclear Magnetic Resonance Imaging

1986 • 102 citations

In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives

1999 • 101 citations

The effect of ouabain on water diffusion in the rat hippocampal slice measured by high resolution NMR imaging

1999 • 101 citations

MR microscopy of multicomponent diffusion in single neurons

2001 • 100 citations

Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology

1997 • 100 citations

T2- and diffusion-weighted magnetic resonance imaging of a focal ischemic lesion in rat brain.

1992 • 99 citations

Nuclear magnetic resonance characteristics of fresh and fixed tissue: the effect of elapsed time.

1983 • 99 citations

Functional magnetic resonance imaging in rats subjected to intense electrical and noxious chemical stimulation of the forepaw

2000 • 92 citations

Blood pool contrast agents for cardiovascular MR imaging

1999 • 91 citations

The temporal evolution of MRI tissue signatures after transient middle cerebral artery occlusion in rat

1997 • 91 citations

Magnetic Resonance Microscopy of the C57BL Mouse Brain

2000 • 90 citations

MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis

1998 • 89 citations

Diffusion anisotropy in excised normal rat spinal cord measured by NMR microscopy

1997 • 88 citations

MR imaging of acute experimental ischemia in cats.

1986 • 87 citations

Unsupervised segmentation of multiparameter MRI in experimental cerebral ischemia with comparison to T2, diffusion, and ADC MRI parameters and histopathological validation

2000 • 87 citations

A model for MRI contrast enhancement using T ₁ agents

1998 • 85 citations

Magnetic resonance microscopy of embryos

1996 • 84 citations

Measurements of T1 and T2 over Time in Formalin-Fixed Human Whole-Brain Specimens

1992 • 82 citations

Pharmacologic Reversal of Acute Changes in Diffusion-Weighted Magnetic Resonance Imaging in Focal Cerebral Ischemia

1994 • 81 citations

A Temporal MRI Assessment of Neuropathology after Transient Middle Cerebral Artery Occlusion in the Rat: Correlations with Behavior

2000 • 79 citations

MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging

2000 • 79 citations

Extracellular apparent diffusion in rat brain

2001 • 78 citations

Study of relapsing remitting experimental allergic encephalomyelitis SJL mouse model using MION-46L enhanced in vivo MRI: Early histopathological correlation

1998 • 78 citations

The Effect of Hypothermia on Transient Focal Ischemia in Rat Brain Evaluated by Diffusion- and Perfusion-Weighted NMR Imaging

1994 • 75 citations

Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies

2001 • 72 citations

Magnetic resonance imaging (MRI) detection of the murine brain response to light: temporal differentiation and negative functional MRI changes.

1996 • 72 citations

Early Detection of Ischemic Injury: Comparison of Spectroscopy, Diffusion-, T2-, and Magnetic Susceptibility-Weighted MRI in Cats

1990 • 69 citations

Postmortem anatomy from cryosectioned whole human brain

1994 • 69 citations

Diffusion and Perfusion Magnetic Resonance Imaging Following Closed Head Injury in Rats

1999 • 67 citations

Proton NMR imaging in experimental ischemic infarction.

1983 • 66 citations

Nuclear magnetic resonance microscopy of single neurons under hypotonic perturbation

1996 • 66 citations

Significance of proton relaxation time measurement in brain edema, cerebral infarction and brain tumors

1986 • 65 citations

Functional Neuroimaging of Cognition

2000 • 65 citations

A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T

1999 • 65 citations

Estrogens Decrease Reperfusion-Associated Cortical Ischemic Damage

2001 • 65 citations

Monitoring the initial expansion of focal ischaemic changes by diffusion‐weighted MRI using a remote controlled method of occlusion

1994 • 64 citations

High-resolution diffusion-weighted MR of fresh and fixed cat spinal cords: evaluation of diffusion coefficients and anisotropy.

1997 • 62 citations

In vitro MR microscopy of the hippocampus in Alzheimer's disease

1993 • 62 citations

Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri‐infarct zone during focal cerebral ischemia

1997 • 61 citations

Temporal evolution of NMDA-induced excitoxicity in the neonatal rat brain measured with 1H nuclear magnetic resonance imaging

1993 • 59 citations

Magnetic resonance microscopy in cardiac development

2001 • 58 citations

Absolute measurements of water content using magnetic resonance imaging: Preliminary findings in an in vivo focal ischemic rat model

2000 • 57 citations

Three‐dimensional MRI microscopy of the normal rat brain

1987 • 57 citations

In vivo imaging of the rat anatomy with nuclear magnetic resonance.

1980 • 56 citations

New approaches for imaging in gene therapy

2000 • 55 citations

Tracking Brain Volume Changes in C57BL/6J and ApoE-Deficient Mice in a Model of Neurodegeneration: A 5-Week Longitudinal Micro-MRI Study

2001 • 54 citations

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

1995 • 53 citations

Diffusion‐weighted MR microscopy with fast spin‐echo

1993 • 51 citations

Cranial anatomy and detection of ischemic stroke in the cat by nuclear magnetic resonance imaging.

1982 • 51 citations

Magnetic resonance imaging of embryos: an Internet resource for the study of embryonic development

1999 • 51 citations

Proton NMR relaxation times in ischemic brain edema.

1986 • 51 citations

Human Malignant Melanomas with Varying Degrees of Melanin Content in Nude Mice

1990 • 50 citations

MRI description of cerebral atrophy in mouse lemur primates

2000 • 49 citations

Cerebral Ischemic Hypoxia: Discrepancy between Apparent Diffusion Coefficients and Histologic Changes in Rats

2000 • 49 citations

A Ventilator for Magnetic Resonance Imaging

1986 • 49 citations

Tomography of hydrogen with nuclear magnetic resonance.

1980 • 49 citations

Effects of calcium antagonists on high‐energy phosphates in ischemic rat brain measured by ³¹P NMR spectroscopy

1987 • 47 citations

Temporal evolution of focal cerebral ischemia in the rat assessed by T2-weighted and diffusion-weighted magnetic resonance imaging

1992 • 47 citations

Use of static and dynamic NMR microscopy to investigate the origins of contrast in images of biological tissues

1994 • 46 citations

Performance of a high-temperature superconducting probe for in vivo microscopy at 2.0 T

1999 • 46 citations

Differentiation of chronic lesions after stroke in stroke‐prone spontaneously hypertensive rats using diffusion weighted MRI

1993 • 43 citations

MR imaging of rat brain glioma: Gd-DTPA versus Gd-DOTA.

1988 • 43 citations

High-Resolution Anatomy from in Situ Human Brain

1994 • 42 citations

Signal changes in the spinal cord of the rat after injection of formalin into the hindpaw: Characterization using functional magnetic resonance imaging

1997 • 42 citations

IL-12 Treatment of Endogenously Arising Murine Brain Tumors

2000 • 40 citations

Three‐dimensional MR microscopy with large arrays

1991 • 40 citations

High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour

2000 • 39 citations

Imaging neuronal development with magnetic resonance imaging (NMR) microscopy

1994 • 38 citations

Cytoprotection does not preserve brain functionality in rats during the acute post-stroke phase despite evidence of non-infarction provided by MRI

2000 • 37 citations

Proton relaxation enhancement in experimental brain tumors—In vivo NMR study of manganese(III)TPPS in rat brain gliomas

1990 • 36 citations

Understanding Magnetic Resonance Imaging

1999 • 36 citations

MR microscopy of perfused brain slices

1997 • 36 citations

Reduction of neural damage in irreversible cerebral ischemia by calcium antagonists

1988 • 35 citations

Diffusion‐weighted NMR imaging changes caused by electrical activation of the brain

1995 • 34 citations

Diffusion‐weighted imaging of kainic acid lesions in the rat brain

1991 • 33 citations

Mixing oxygen with hyperpolarized3He for small-animal lung studies

2000 • 33 citations

Cerebrovascular, biochemical, and cytoprotective effects of isradipine in laboratory animals

1989 • 33 citations

Status of the Neonatal Rat Brain after NMDA-Induced Excitotoxic Injury as Measured by MRI, MRS and Metabolic Imaging

1996 • 33 citations

CONTRAST ENHANCEMENT IN MAGNETIC RESONANCE IMAGING USING INTRAVENOUS PARAMAGNETIC CONTRAST MEDIA: A REVIEW

2000 • 33 citations

Detectability of Hepatomas in Rat Livers by Nuclear Magnetic Resonance Imaging

1981 • 32 citations

Non invasive in vivo anatomical studies of the oscine brain by high resolution MRI microscopy

1998 • 32 citations

Pre‐ and postmortem diffusion coefficients in rat neural and muscle tissues

1991 • 30 citations

Prolonged General Anesthesia in MR Studies of Rats

2001 • 29 citations

Topographical localization of iron in brains of the aged fat-tailed dwarf lemur(Cheirogaleus medius) and gray lesser mouse lemur(Microcebus murinus)

1998 • 28 citations

Does diffusion-weighted magnetic resonance imaging enable detection of early ischemic change following transient cerebral ischemia?

2000 • 28 citations

MRI characterization of 9L-glioma in rat brain at 4.7 Tesla

1990 • 28 citations

The Design and Construction of a NMR Microscopy Probe

1994 • 28 citations

Three dimensional magnetic resonance microangiography of rat neurovasculature

1994 • 27 citations

In vivo relaxometry of three brain tumors in the rat: Effect of Mn‐TPPS, a tumor‐selective contrast agent

1993 • 27 citations

Proton Nuclear Magnetic Resonance Imaging of Acute Experimental Cerebral Ischemia

1983 • 26 citations

Mouse Lemur Microscopic MRI Brain Atlas

1994 • 26 citations

A new gadolinium‐based contrast agent for magnetic resonance imaging of brain tumors: Kinetic study on a C6 rat glioma model

2001 • 25 citations

Magnetic resonance imaging of experimental demyelinating lesions

1990 • 23 citations

Herpes simplex virus encephalitis: cranial magnetic resonance imaging and neuropathology in a mouse model

1998 • 23 citations

fMRI: methodology--cognitive function mapping.

2000 • 22 citations

NMR Imaging of Acute Experimental Cerebral Ischemia: Time Course and Pharmacologic Manipulations

1983 • 22 citations

Contrast Media Research

1999 • 21 citations

MR microscopy on rats in vivo at 4.7 T using surface coils

1987 • 21 citations

A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal striatal tissue transplants and gliomas in rat brain in vivo

1989 • 21 citations

A peroxidative model of human erythrocyte intracellular Ca2+ changes with in vivo cell aging: Measurement by 19F-NMR spectroscopy

1995 • 20 citations

Quantitative magnetic resonance imaging of rat brain tumors: in vivo NMR relaxometry for the discrimination of normal and pathological tissues.

1994 • 20 citations

Quantitative magnetic resonance imaging of rat brain tumors: In vivo NMR relaxometry for the discrimination of normal and pathological tissues

1994 • 19 citations

Magnetic resonance imaging of the normal mouse brain: comparison with histologic sections.

1995 • 19 citations

Small animal imaging with a clinical magnetic resonance imager

1987 • 18 citations

Biomedical Imaging Symposium: Visualizing the Future of Biology and Medicine

2000 • 18 citations

NMR microscopy — beginnings and new directions

1999 • 17 citations

Monitoring the CNS Pathology in Aspartylglucosaminuria Mice

1998 • 17 citations

In vivo diffusion-weighted magnetic resonance microscopy of rat spinal cord: Effect of ischemia and intrathecal hyperbaric 5% lidocaine*1

1999 • 15 citations

In vitro NMR micro imaging of the spinal cord of chronic relapsing EAE rats

1994 • 15 citations

Glioblastoma multiforme: MR imaging at 1.5 and 9.4 T after injection of polylysine-DTPA-Gd in rats.

1990 • 14 citations

Proton NMR studies on ischemic rat brain tissue

1992 • 14 citations

Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/nmda antagonist: An in vivo three‐dimensional diffusion‐weighted MR microscopy study

1997 • 13 citations

Spinal cord neural anatomy in rats examined by In Vivo magnetic resonance microscopy*1

1998 • 13 citations

MRI measurement of cell volume fraction in the perfused rat hippocampal slice

1999 • 12 citations

What are the goals of magnetic resonance research?

1989 • 12 citations

Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking.

2000 • 11 citations

Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors

1994 • 11 citations

fMRI: methodology--sensorimotor function mapping.

2000 • 11 citations

Comparison of diffusion, blood oxygenation, and blood volume changes during global ischemia in rats

2001 • 11 citations

Brain Edema Studied by Magnetic Resonance

1986 • 10 citations

Magnetic resonance imaging of estrogen‐induced pituitary hypertrophy in rats

1989 • 10 citations

NMR microscopy—beginnings and new directions

1999 • 9 citations

Some biophysical applications of motional contrast in n.m.r. microscopy

1991 • 8 citations

Experimental cerebral infarction in the rat: Utility of Gd-DOTA for MR imaging

1990 • 7 citations

fMRI: methodology--acquisition and processing.

2000 • 7 citations

A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy

1996 • 6 citations

MRI Contrast Enhancement by Mn-TPPS in Experimental Rat Brain Tumor with Peripheral Benzodiazepine Receptors

1994 • 5 citations

Spinal Cord Neural Anatomy in Rats Examined by In Vivo Magnetic Resonance Microscopy

1998 • 4 citations