The local lymph node assay: developments and applications

The Identification of Contact Allergens by Animal Assay. the Guinea Pig Maximization Test**From the Department of Dermatology, University of Gothenburg, Sahlgrenska Sjukhuset, Gothenburg, Sweden and the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.

1969 • 923 citations

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1935 • 697 citations

Early molecular events in the induction phase of contact sensitivity.

1992 • 660 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

Delayed Contact Hypersensitivity In the Guinea Pig

1965 • 515 citations

The Freund�s Complete Adjuvant Test and the Open Epicutaneous Test

2015 • 500 citations

Experiments on Transfer of Cutaneous Sensitivity to Simple Compounds

1942 • 410 citations

Development and validation of an alternative dermal sensitization test: The mouse ear swelling test (MEST)

1986 • 384 citations

Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer.

1968 • 379 citations

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

1992 • 327 citations

Allergic Contact Dermatitis in the Guinea Pig

1971 • 289 citations

The murine local lymph node assay: A commentary on collaborative studies and new directions

1992 • 285 citations

A murine local lymph node assay for the identification of contact allergens

1989 • 278 citations

Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens

1992 • 278 citations

SCREENING OF FRAGRANCE MATERIALS FOR ALLERGENICITY IN THE GUINEA PIG. I. COMPARISON OF FOUR TESTING METHODS.

1977 • 205 citations

Current Topics in Contact Dermatitis

1989 • 190 citations

Guinea Pig Maximization Test

2015 • 173 citations

A HISTOLOGICAL AND AUTORADIOGRAPHIC STUDY OF LYMPH NODES DURING THE DEVELOPMENT OF CONTACT SENSITIVITY IN THE GUINEA-PIG.

1965 • 168 citations

The murine local lymph node assay for identification of contact allergens: a preliminary evaluation of in situ measurement of lymphocyte proliferation

1989 • 147 citations

Differential stimulation of immune function by respiratory and contact chemical allergens.

1991 • 145 citations

Development of a murine local lymph node assay for the determination of sensitizing potential

1986 • 137 citations

The murine local lymph node assay: results of an inter-laboratory trial

1991 • 132 citations

Dendritic cells and cutaneous immune responses to chemical allergens

1992 • 127 citations

Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential

1991 • 121 citations

A comparison of three guinea‐pig sensitization procedures for the detection of 19 reported human contact sensitizers

1981 • 117 citations

Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation

1993 • 111 citations

The morphology of immune reactions in normal, thymectomized and reconstituted mice. II. The response to oxazolone.

1969 • 107 citations

The value of the local lymph node assay in quantitative structure‐activity investigations

1992 • 106 citations

Examination of the local lymph node assay for use in contact sensitization risk assessment

1992 • 106 citations

Interlaboratory Evaluation of the Local Lymph Node Assay with 25 Chemicals and Comparison with Guinea Pig Test Data

1991 • 102 citations

Variable effects of chemical allergens on serum ige concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers

1992 • 102 citations

Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone

1992 • 100 citations

CYTOLOGY OF THE INDUCTION OF HYPERSENSITIVITY

1967 • 98 citations

Contact allergy predictive tests in guinea pigs.

1985 • 95 citations

Assessment of the ability of mice fed on vitamin A supplemented diet to respond to a variety of potential contact sensitizers

1986 • 94 citations

Immune responses in congenitally thymus-less mice. I. Absence of response to oxazolone.

1972 • 90 citations

Identification of contact allergens using the murine local lymph node assay: Comparisons with the buehler occluded patch test in guinea pigs

1990 • 90 citations

The local lymph node assay: Results of a final inter‐laboratory validation under field conditions

1992 • 89 citations

Changes in the Thymus-Dependent Areas of Lymph Nodes After Immunological Stimulation

1966 • 88 citations

The optimization test in the guinea pig in relation to other predictive sensitization methods

1980 • 87 citations

INDUCTION AND RECALL IN CONTACT SENSITIVITY

1969 • 78 citations

Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays

1993 • 75 citations

A modified technique of guinea pig testing to identify delayed hypersensitivity allergens

1981 • 71 citations

Detection of contact sensitivity of metal salts using the murine local lymph node assay

1992 • 71 citations

The noninvasive mouse ear swelling assay *1I. Refinements for detecting weak contact sensitizers

1991 • 68 citations

T-cell-mediated enhancement of host-versus-graft reactivity in mice fed a diet enriched in vitamin A acetate

1983 • 67 citations

Identification of Contact Allergens: The Mouse Ear Sensitization Assay

1988 • 66 citations

Characterization of murine immune responses to allergenic diisocyanates

1992 • 66 citations

Copper – a rare sensitizer

1983 • 64 citations

A quantitative structure activity/dose response relationship for contact allergic potential of alkyl group transfer agents

1990 • 57 citations

Guinea Pig Sensitization Assays

2015 • 56 citations

Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay

1991 • 55 citations

The Optimization Test

2015 • 55 citations

Variability of a mouse ear swelling test (MEST) in predicting weak and moderate contact sensitization

1990 • 54 citations

A Rationale for the Selection of Occlusion to Induce and Elicit Delayed Contact Hypersensitivity in the Guinea Pig

2015 • 53 citations

The optimization test in the guinea-pig. A method for the predictive evaluation of the contact allergenicity of chemicals

1975 • 50 citations

Enhancement of specific antitumor immunity in mice fed a diet enriched in vitamin A acetate.

1983 • 48 citations

Comparison of a radioisotopic incorporation method and the mouse ear swelling test (MEST) for contact sensitivity to weak sensitizers

1988 • 48 citations

Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.

1993 • 47 citations

Sulphanilic acid: divergent results in the guinea pig maximization test and the local lymph node assay

1992 • 45 citations

Contact sensitization of mice to nickel sulphate and potassium dichromate

1990 • 42 citations

Irritant dermatitis from tri‐butyl tin oxide and contact allergy from chlorocresol

1987 • 41 citations

The noninvasive mouse ear swelling assay *1II. Testing the contact sensitizing potency of fragrances

1991 • 38 citations

Experiments on transfer of cutaneous sensitivity to simple compounds

1942 • 38 citations

The Draize Test and Modifications

2015 • 38 citations

Use of the Albino Guinea-pig to Detect the Skin-sensitizing Ability of Chemicals

1967 • 37 citations

The Cumulative Contact Enhancement Test

2015 • 37 citations

Irritant dermatitis from tri‐N‐butyl tin oxide in paint

1985 • 37 citations

Aspects of the immune response to contact allergens: Opportunities for the development and modification of predictive test methods

1989 • 36 citations

Immunological aspects of contact sensitivity : an experimental study

1980 • 35 citations

Anamnestic responses to contact allergens: Application in the murine local lymph node assay

1991 • 32 citations

Evaluation of contact sensitivity of rubber chemicals using the murine local lymph node assay

1993 • 32 citations

Regulation of lymphocyte proliferation in contact sensitivity: homeostatic mechanisms and a possible explanation of antigenic competition.

1989 • 31 citations

Studies on contact hypersensitivity in the guinea pig The cumulative contact enhancement test

1982 • 29 citations

A quantitative structure-activity/dose relationship for contact allergenic potential of alkyl group transfer agents

1990 • 27 citations

Single Injection Adjuvant Test

2015 • 27 citations

Structure/activity relationships in contact allergy

1990 • 26 citations

Studies of new short-period method for delayed contact hypersensitivity assay in the guinea pig

1993 • 25 citations

The cellular and molecular basis for divergent allergic responses to chemicals

1992 • 25 citations

Approaches to the identification and classification of chemical allergens in mice

1993 • 24 citations

Models for contact sensitization-novel approaches and future developments

1986 • 23 citations

Interleukin 6 (IL-6) Production by Lymph Node Cells: An Alternative Endpoint for the Murine Local Lymph Node Assay

1993 • 22 citations

The maximization test for skin sensitization potential—Updating the standard protocol and validation of a modified protocol

1989 • 20 citations

Evaluation of the sensitising potential of 4 polyamines present in technical triethylenetetramine using 2 animal species

1988 • 18 citations

Experimental nickel sensitization in the guinea pig: comparison of different protocols

1985 • 16 citations

Antigen-specific inhibition of IL-2 and IL-3 production in contact sensitivity to TNP.

1989 • 16 citations

The identification of photoallergic potential in the local lymph node assay.

1991 • 16 citations

A Modified Murine Local Lymph Node Assay for Identification of Contact Allergens

1989 • 12 citations

The Murine Local Lymph Node Assay: Principles and Practice

1993 • 12 citations

Classification of chemicals as sensitisers based on new test methods

1992 • 11 citations

Split Adjuvant Technique1

2015 • 11 citations

Further studies on the regulation of lymphokine biosynthesis in contact sensitivity

1990 • 9 citations

The TINA test.

1985 • 9 citations

Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice.

1990 • 9 citations

Modified Guinea Pig Maximization Test

2015 • 9 citations

Toxic skin reactions caused by tributyltin oxide (tbto) in socks.

1975 • 8 citations

The Murine Local Lymph Node Assay: Principles and Practice

1993 • 8 citations

Contact sensitivity (allergic contact dermatitis) to bis(tri‐n‐butyltin) oxide in mice

1991 • 7 citations

Chemical Allergy: Molecular Mechanisms and Practical Applications*1

1992 • 7 citations

Antigen-Restricted Antigenic Competition Induced by 2,4-Dinitrochlorobenzene: Association with Depression of Lymphocyte Proliferation

1990 • 7 citations

Deleted Work

1955 • 0 citations

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