cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The detection and classification of membrane-spanning proteins

1985 • 854 citations

A functional ribonucleoprotein complex forms around the 5′ end of poliovirus RNA

1990 • 494 citations

PROTEOLYTIC PROCESSING OF PICORNAVIRAL POLYPROTEIN

1990 • 357 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Association of polioviral proteins of the P2 genomic region with the viral replication complex and virus-induced membrane synthesis as visualized by electron microscopic immunocytochemistry and autoradiography

1987 • 274 citations

The location of the polio genome protein in viral RNAs and its implication for RNA synthesis

1977 • 268 citations

The role of cytoplasmic membranes in poliovirus biosynthesis

1970 • 250 citations

Structural organization of poliovirus RNA replication is mediated by viral proteins of the P2 genomic region

1990 • 241 citations

An internal signal sequence: The asialoglycoprotein receptor membrane anchor

1986 • 209 citations

The Replication of Picornaviruses

1979 • 204 citations

Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing

1986 • 202 citations

Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A).

1977 • 188 citations

Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence

1988 • 185 citations

Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells

1986 • 165 citations

Two related Epstein-Barr virus membrane proteins are encoded by separate genes

1989 • 161 citations

Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus.

1983 • 157 citations

Mechanisms of integration of de novo-synthesized polypeptides into membranes: signal-recognition particle is required for integration into microsomal membranes of calcium ATPase and of lens MP26 but not of cytochrome b5.

1983 • 155 citations

Identification of poliovirus polypeptide P63 as a soluble RNA-dependent RNA polymerase

1980 • 154 citations

A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide

1982 • 148 citations

The poliovirus replication complex: Site for synthesis of poliovirus RNA

1967 • 140 citations

Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides

1983 • 136 citations

Genetic complementation among poliovirus mutants derived from an infectious cDNA clone

1986 • 132 citations

Isolation of poliovirus 2C mutants defective in viral RNA synthesis

1988 • 126 citations

Construction and characterization of poliovirus subgenomic replicons

1988 • 123 citations

Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis

1991 • 114 citations

Poliovirus Polyuridylic Acid Polymerase and RNA Replicase Have the Same Viral Polypeptide

1979 • 112 citations

Identification of a protein linked to nascent poliovirus RNA and to the polyuridylic acid of negative-strand RNA

1978 • 112 citations

Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity

1986 • 108 citations

Cleavage of synthetic peptides by purified poliovirus 3C proteinase

1989 • 102 citations

A poliovirus temperature-sensitive RNA synthesis mutant located in a noncoding region of the genome.

1986 • 101 citations

Oligonucleotide-Directed Site-Specific Mutagenesis Using Double-Stranded Plasmid DNA

1987 • 94 citations

Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus

1991 • 92 citations

Genome-linked protein VPg of poliovirus is present as free VPg and VPg-pUpU in poliovirus-infected cells.

1983 • 90 citations

Isolation of a Viral Polypeptide Associated with Poliovirus RNA Polymerase

1974 • 88 citations

A detailed kinetic analysis of the in Vitro synthesis and processing of encephalomyocarditis virus products

1986 • 84 citations

Picornavirus Protein Processing—Enzymes, Substrates, and Genetic Regulation

1990 • 81 citations

Analysis of RNA synthesis of type 1 poliovirus by using an in vitro molecular genetic approach

1987 • 81 citations

in vitromolecular genetics as a tool for determining the differential cleavage specificities of the polivirus 3C proteinase

1987 • 81 citations

Defined recombinants of poliovirus and coxsackievirus: Sequence-specific deletions and functional substitutions in the 5′-noncoding regions of viral RNAs

1988 • 79 citations

Processing determinants required for in vitro cleavage of the poliovirus P1 precursor to capsid proteins

1987 • 68 citations

Co-translational membrane integration of calcium pump protein without signal sequence cleavage

1981 • 67 citations

Characterization of poliovirus clones containing lethal and nonlethal mutations in the genome-linked protein VPg

1990 • 62 citations

Association of the polioviral RNA polymerase complex with phospholipid membranes

1976 • 59 citations

Synthesis and Processing of Picornaviral Polyprotein

1979 • 59 citations

Mutational analysis of the genome-linked protein VPg of poliovirus

1988 • 59 citations

Structure of poliovirus replicative intermediate RNA

1984 • 58 citations

Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase

1991 • 52 citations

Proteolytic activity of hepatitis A virus 3C protein

1991 • 52 citations

trans rescue of a mutant poliovirus RNA polymerase function

1991 • 51 citations

Association of poliovirus proteins with the endoplasmic reticulum

1984 • 50 citations

Poliovirus mutant that contains a cold-sensitive defect in viral RNA synthesis

1988 • 48 citations

Anti-VPg antibody inhibition of the poliovirus replicase reaction and production of covalent complexes of VPg-related proteins and RNA

1982 • 48 citations

Analysis of RNA associated with the poliovirus RNA replication complexes

1974 • 34 citations

Antibody to a synthetic nonapeptide corresponding to the NH2 terminus of poliovirus genome-linked protein VPg reacts with native VPg and inhibits in vitro replication of poliovirus RNA

1983 • 31 citations

ATP is required for initiation of poliovirus RNA synthesis in vitro: demonstration of tyrosine-phosphate linkage between in vitro-synthesized RNA and genome-linked protein

1984 • 31 citations

Structural studies of the RNA component of the poliovirus replication complex Purification and biochemical characterization

1978 • 19 citations

Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids

1987 • 17 citations