Inhibition of thrombin generation by the zymogen factor VII: implications for the treatment of hemophilia A by factor VIIa

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

1977 • 791 citations

Characterization of a cDNA coding for human factor VII.

1986 • 450 citations

Frapper fort ou doucement:A Gramnegative dilemma.

1978 • 358 citations

A model for the tissue factor pathway to thrombin. I. An empirical study.

1994 • 242 citations

A Simplified Procedure for Purification of Human Prothrombin, Factor IX and Factor X

1981 • 222 citations

Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII

1975 • 215 citations

The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.

1993 • 202 citations

Regulation of Tissue Factor Initiated Thrombin Generation by the Stoichiometric Inhibitors Tissue Factor Pathway Inhibitor, Antithrombin-III, and Heparin Cofactor-II

1997 • 199 citations

Blood Coagulation in Hemophilia A and Hemophilia C

1998 • 189 citations

Activation of Human Factor VII in Plasma and in Purified Systems

1979 • 167 citations

Surface-dependent hemostasis.

1992 • 167 citations

Measurement of basal levels of factor VIIa in hemophilia A and B patients [see comments]

1992 • 166 citations

Reactive site peptide structural similarity between heparin cofactor II and antithrombin III.

1985 • 149 citations

[21] Factor V

1981 • 138 citations

Complex-dependent inhibition of factor VIIa by antithrombin III and heparin.

1993 • 137 citations

Evaluation of the Initiation Phase of Blood Coagulation Using Ultrasensitive Assays for Serine Proteases

1997 • 134 citations

Activation of bovine factor VII (proconvertin) by factor XIIa (activated Hageman factor)

1977 • 131 citations

Inhibitory Mechanism of the Protein C Pathway on Tissue Factor-induced Thrombin Generation

1997 • 122 citations

Factor‐Xa Inactivation by Antithrombin III

1973 • 120 citations

A possible mechanism of action of activated factor VII independent of tissue factor.

1998 • 106 citations

Recombinant activated factor VII as a universal haemostatic agent.

1998 • 102 citations

The evaluation of complex-dependent alterations in human factor VIIa.

1992 • 98 citations

Kinetics of Human Factor VII Activation

1996 • 94 citations

Blocking of tissue factor pathway inhibitor (TFPl) shortens the bleeding time in rabbits with antibody induced haemophilia A

1995 • 92 citations

The dual role of factor VII in blood coagulation. Initiation and inhibition of a proteolytic system by a zymogen.

1982 • 91 citations

Dosing and Monitoring NovoSeven® Treatment

1996 • 81 citations

Physiological concentrations of tissue factor pathway inhibitor do not inhibit prothrombinase

1996 • 77 citations

Activation of human factor VII by factors IXa and Xa on human bladder carcinoma cells

1989 • 60 citations

Factor IXa-factor VIIIa-cell surface complex does not contribute to the basal activation of the coagulation mechanism in vivo

1992 • 59 citations

Hemophilia as a defect of the tissue factor pathway of blood coagulation: effect of factors VIII and IX on factor X activation in a continuous-flow reactor.

1990 • 56 citations

Continuous infusion of recombinant factor VIIa in patients with haemophilia and inhibitors Experience in the Netherlands and Belgium.

1998 • 50 citations

How to Measure Factor VII and Factor VII Activation

1983 • 46 citations

Activated factor X and thrombin formation triggered by tissue factor on endothelial cell matrix in a flow model: effect of the tissue factor pathway inhibitor

1994 • 44 citations

Activation of human factor VII during clotting in vitro

1985 • 43 citations

A Novel Specific Immunoassay for Plasma Two-Chain Factor VIIa: Investigation of FVIIa Levels in Normal Individuals and in Patients With Acute Coronary Syndromes

1997 • 41 citations

Evaluation of a Coagulation Assay Determining the Activity State of Factor VII in Plasma

1983 • 23 citations

Interaction of activated factor VII and active site-inhibited activated factor VII with tissue factor.

1998 • 11 citations

Activation of human factor VII during clotting in vitro

1985 • 5 citations

Deleted Work

1955 • 0 citations