Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

Neuropeptide Y: complete amino acid sequence of the brain peptide.

1982 • 1,360 citations

Neuropeptide Y (NPY)‐like immunoreactivity in peripheral noradrenergic neurons and effects of NPY on sympathetic function

1982 • 1,206 citations

Neuropeptide Y co-exists and co-operates with noradrenaline in perivascular nerve fibers

1984 • 735 citations

Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides

1986 • 632 citations

Progress in Brain Research

1969 • 591 citations

Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to α‐adrenoceptor blockade

1982 • 533 citations

Effect of colchicine on transport of amine storage granules in sympathetic nerves of rat

1968 • 446 citations

Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen

1986 • 355 citations

Neuropeptide Y: Cerebrovascular innervation an vasomotor effects in the cat

1983 • 317 citations

Comparative immunohistochemical and biochemical analysis of pancreatic polypeptide-like peptides with special reference to presence of neuropeptide Y in central and peripheral neurons

1984 • 307 citations

Chapter 16 Multiple co-existence of peptides and classical transmitters in peripheral autonomic and sensory neurons—functional and pharmacological implications

1986 • 273 citations

Neuropeptide Y (NPY) depresses the secretion of ³H‐noradrenaline and the contractile response evoked by field stimulation, in rat vas deferens

1984 • 270 citations

Guanine nucleotide-binding protein Go-induced coupling of neuropeptide Y receptors to Ca2+ channels in sensory neurons.

1988 • 242 citations

Co-release of neuropeptide Y and catecholamines during physical exercise in man

1985 • 216 citations

Plasma neuropeptide Y‐like immunoreactivity and catecholamines during various degrees of sympathetic activation in man

1986 • 205 citations

Coexistence of an avian pancreatic polypeptide (APP) immunoreactive substance and catecholamines in some peripheral and central neurons

1980 • 197 citations

Guanethidine-sensitive release of neuropeptide Y-like immunoreactivity in the cat spleen by sympathetic nerve stimulation

1984 • 193 citations

Increased Tyrosine Hydroxylase Activity after Drug-induced Alteration of Sympathetic Transmission

1969 • 184 citations

Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport

1989 • 184 citations

Prolonged non-adrenergic inhibition of cardiac vagal action following sympathetic stimulation: Neuromodulation by neuropeptide Y?

1985 • 182 citations

Adrenergic Neurone Blocking Agents

1965 • 178 citations

Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea‐pig

1984 • 177 citations

Two novel related peptides, neuropeptide Y (NPY) and peptide YY (PYY) inhibit the contraction of the electrically stimulated mouse vas deferens

1982 • 172 citations

Release of norepinephrine and dopamine-beta-hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors.

1974 • 165 citations

Mechanisms underlying pre‐ and postjunctional effects of neuropeptide Y in sympathetic vascular control

1986 • 160 citations

Neuropeptide Y: Immunocytochemical localization to and effect upon feline pial arteries and veins in vitro and in situ

1984 • 159 citations

Neuropeptide Y—A cotransmitter with noradrenaline and adenosine 5′-Triphosphate in the sympathetic nerves of the mouse vas deferens? A biochemical, physiological and electropharmacological study

1986 • 142 citations

Neuropeptide Y and sympathetic control of heart contractility and coronary vascular tone

1985 • 141 citations

Neuropeptide Y-like immunoreactivity in adrenaline cells of adrenal medulla and in tumors and plasma of pheochromocytoma patients

1986 • 140 citations

Differential release of calcitonin gene‐related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain

1989 • 135 citations

Vasoconstrictor effects in vivo and plasma disappearance rate of neuropeptide Y in man

1987 • 133 citations

Neuropeptide Y receptor in pig spleen: binding characteristics, reduction of cyclic AMP formation and calcium antagonist inhibition of vasoconstriction

1988 • 127 citations

Differential effects of reserpine and 6-hydroxydopamine on neuropeptide Y (NPY) and noradrenaline in peripheral neurons

1985 • 126 citations

Neuropeptide Y is a potent inhibitor of cyclic AMP accumulation in feline cerebral blood vessels

1985 • 124 citations

Subcellular storage and axonal transport of neuropeptide Y (NPY) in relation to catecholamines in the cat

1985 • 118 citations

Effects of arterial pH and carbon dioxide on pancreatic exocrine H⁺/HCO^‐₃ secretion and secretin‐dependent translocation of cytoplasmic vesicles in pancreatic duct cells

1988 • 117 citations

Co-release and functional interactions of neuropeptide Y and noradrenaline in peripheral sympathetic vascular control.

1988 • 108 citations

Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice.

1987 • 107 citations

Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

1988 • 106 citations

Plasma neuropeptide Y on admission to a coronary care unit: raised levels in patients with left heart failure

1990 • 102 citations

Neuropeptide Y (NPY) and the pig heart: Release and coronary vasoconstrictor effects

1986 • 99 citations

The storage of endogenous noradrenaline in sympathetic nerve terminals

1971 • 96 citations

Characterization and presynaptic modulation of stimulation-evoked exocytotic co-release of noradrenaline and neuropeptide Y in guinea pig heart

2004 • 90 citations

Co‐release of neuropeptide Y and catecholamines upon adrenal activation in the cat

1986 • 89 citations

‘Neuropeptide tyrosine’ (NPY) is co-stored with noradrenaline in vascular but not in parenchymal sympathetic nerves of brown adipose tissue

1986 • 82 citations

Neuropeptide Y: presence in perivascular noradrenergic neurons and vasoconstrictor effects on skeletal muscle blood vessels in experimental animals and man

1987 • 82 citations

Actions of neuropeptide Y on innervated and denervated rat tail arteries.

1987 • 71 citations

Evidence for co‐transmitter role of neuropeptide Y in the pig spleen

1989 • 70 citations

Neuropeptide Y modulates adrenergic neurotransmission by an endothelium dependent mechanism

1987 • 66 citations

Adenosine and neuropeptide Y enhance α1-adrenoceptor-induced accumulation of inositol phosphates and attenuate forskolin-induced accumulation of cyclic AMP in rat vas deferens

1987 • 65 citations

Modulation of noradrenaline and neuropeptide Y (NPY) release in the pig kidney in vivo: involvement of alpha2, NPY and angiotensin II receptors

1989 • 65 citations

Neuropeptide y- and alpha-adrenergic receptors in pig spleen: Localization, binding characteristics, cyclic amp effects and functional responses in control and denervated animals

1988 • 63 citations

Potent effects of neuropeptide Y and calcitonin gene‐related peptide on human coronary vascular gene in vitro

1987 • 58 citations

Actions of calcium antagonists on pre- and postjunctional effects of neuropeptide Y on human peripheral blood vessels in vitro

1987 • 58 citations

Effects of Antihypertensive Drugs on Sympathetic Vascular Control in Relation to Neuropeptide Y

1986 • 56 citations

Neuropeptide Y and noradrenaline mechanisms in relation to reserpine induced impairment of sympathetic neurotransmission in the cat spleen

1987 • 56 citations

Release of neuropeptide Y upon haemorrhagic hypovolaemia in relation to vasoconstrictor effects in the pig

1987 • 56 citations

Release and vasoconstrictor effects of neuropeptide Y in relation to non‐adrenergic sympathetic control of renal blood flow in the pig

1989 • 53 citations

Mechanisms underlying changes in the contents of neuropeptide Y in cardiovascular nerves and adrenal gland induced by sympatholytic drugs

1985 • 51 citations

α2-Adrenoceptor-mediated inhibition of nerve stimulation-evoked release of neuropeptide Y (NPY)-like immunoreactivity in the pithed guinea-pig

1986 • 51 citations

Co‐release of neuropeptide Y (NPY)‐like immunoreactivity and catecholamines in newborn infants

1986 • 47 citations

Neuropeptide Y And Noradrenaline Interaction in Peripheral Cardiovascular Control

1984 • 45 citations

Lschaemia and changes in contractility induce release of calcitonin gene‐related peptide but not neuropeptide Y from the isolated perfused guineapig heart

1987 • 41 citations

Sympathetic vascular control of the pig nasal mucosa (III): co‐release of noradrenaline and neuropeptide Y

1989 • 40 citations

Pharmacological characterization of neuropeptide Y and noradrenaline mechanisms in sympathetic control of pig spleen

1989 • 40 citations

Reserpine-induced depletion of neuropeptide Y from cardiovascular nerves and adrenal gland due to enhanced release

1986 • 39 citations

Sympathetic vascular control of the pig nasal mucosa (2): reserpine‐resistant, non‐adrenergic nervous responses in relation to neuropeptide Y and ATP

1988 • 37 citations

α-Adrenoceptor Influence on Plasma Levels of Neuropeptide Y-Like Immunoreactivity and Catecholamines During Rest and Sympathoadrenal Activation in Humans

1988 • 35 citations

The antiadrenergic effect of neuropeptide Y on the ventricular cardiomyocyte

1988 • 32 citations

Neuropeptide Y and non-adrenergic sympathetic vascular control of the cat nasal mucosa

1987 • 31 citations

Neuropeptide Y and reserpine‐resistant vasoconstriction evoked by sympathetic nerve stimulation in the dog skeletal muscle

1988 • 31 citations

Reserpine-induced depletion of neuropeptide Y in the guinea-pig: tissue-specific effects and mechanisms of action

1987 • 29 citations

Neuropeptide Y induces potent contraction of arterial vascular smooth muscle via an endothelium‐independent mechanism

1988 • 28 citations

Nicotine-induced release of noradrenaline and neuropeptide Y in guinea pig heart.

1988 • 27 citations

Facilitation of the release of noradrenaline and neuropeptide Y by the α2-adrenoceptor blocking agents idazoxan and hydergine in the dog spleen

1988 • 25 citations

Increased neuropeptide Y messenger RNA and peptide in sympathetic ganglia after reserpine pretreatment

1988 • 24 citations

Cigarette smoke‐induced elevation of plasma neuropeptide Y levels in man

1989 • 24 citations

Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat

1988 • 22 citations

Renal sympathetic nerve activation in relation to reserpine‐induced depletion of neuropeptide Y in the kidney of the rat

1988 • 19 citations

The influence of Atriopeptins I and II on the relationship between glomerular filtration and natriuresis

1987 • 19 citations

Adrenergic and neuropeptide Y supersensitivity in denervated nasal mucosa vasculature of the pig

1989 • 17 citations

Differential effects of clonidine and reserpine treatment on neuropeptide Y content in some sympathetically innervated tissues of the guinea-pig

1987 • 16 citations

Effects of vinblastine on neuropeptide Y levels in the sympathoadrenal system, bone marrow and thrombocytes of the rat

1991 • 6 citations