Alloreactive T Cell Responses and Acute Rejection of Single Class II MHC-Disparate Heart Allografts Are under Strict Regulation by CD4+CD25+ T Cells

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells

2003 • 893 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

2002 • 766 citations

The Technique of Free Skin Grafting in Mammals

1951 • 760 citations

Migration and maturation of Langerhans cells in skin transplants and explants.

1990 • 663 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo

2003 • 600 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses

2003 • 531 citations

CD8 T Cell Responses to Infectious Pathogens

2003 • 433 citations

In vivodynamics of antigen-specific regulatory T cells not predicted from behaviorin vitro

2003 • 384 citations

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance

2002 • 372 citations

Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice

1999 • 303 citations

Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.

1990 • 302 citations

Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction

1992 • 295 citations

Favorably Tipping the Balance between Cytopathic and Regulatory T Cells to Create Transplantation Tolerance

2003 • 255 citations

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

2002 • 241 citations

Two levels of help for B cell alloantibody production.

1996 • 212 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells

2003 • 177 citations

Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection

2001 • 172 citations

B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

1979 • 161 citations

T Cell Infiltration into Class II MHC-Disparate Allografts and Acute Rejection Is Dependent on the IFN-γ-Induced Chemokine Mig

1999 • 136 citations

Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant.

1984 • 126 citations

Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size

2002 • 78 citations

Molecular genetic analysis of 178 I-Abm12-reactive T cells.

1989 • 76 citations

Effects of T Cell Frequency and Graft Size on Transplant Outcome in Mice

2004 • 71 citations

The Role of MIG/CXCL9 in Cardiac Allograft Vasculopathy

2002 • 65 citations

Intraallograft Chemokine RNA and Protein During Rejection of MHC-Matched/Multiple Minor Histocompatibility-Disparate Skin Grafts

2000 • 48 citations

MIGRATION OF DENDRITIC CELLS TO THE DRAINING LYMPH NODE AFTER ALLOGENEIC OR CONGENEIC RAT SKIN TRANSPLANTATION1

1999 • 38 citations

SEROLOGICAL AND BIOCHEMICAL ANALYSIS OF Ia MOLECULES IN THE I-A MUTANT B6.C-H-2

1981 • 35 citations

Absence of Allograft ICAM-1 Attenuates Alloantigen-Specific T Cell Priming, But Not Primed T Cell Trafficking into the Graft, to Mediate Acute Rejection

2003 • 28 citations

Alloantibody Production is Regulated by CD4+ T Cells' Alloreactive Pathway, Rather Than Precursor Frequency or Th1/Th2 Differentiation

2004 • 24 citations