Intraclonal Heterogeneity in theIn VitroDaunorubicin-Induced Apoptosis in Acute Myeloid Leukemia

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

A novel form of Epstein-Barr virus latency in normal B cells in vivo

1995 • 1,552 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy

1993 • 738 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1993 • 292 citations

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.

1993 • 280 citations

p53 in hematologic malignancies

1994 • 269 citations

Cell growth and differentiation

2005 • 226 citations

p53 in hematologic malignancies

1994 • 206 citations

Programmed cell death (apoptosis) and response to anti-cancer drugs

1994 • 185 citations

Response to salvage therapy and survival after relapse in acute myelogenous leukemia.

1989 • 178 citations

The relationship between bcl‐2 expression and response to chemotherapy in acute leukaemia

1994 • 165 citations

Effects of BCL-2 antisense oligodeoxynucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells

1994 • 162 citations

Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide.

1995 • 137 citations

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.

1992 • 113 citations

Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia.

1995 • 98 citations

Association of bcl-2, bax, bcl-xL and interleukin-1 beta-converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia.

1996 • 92 citations

Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.

1992 • 83 citations

The frequency of long‐term remission in patients with acute myelogenous leukaemia treated with conventional maintenance chemotherapy: a study of 760 patients with a minimal follow‐up time of 6 years

1989 • 77 citations

Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines.

1996 • 69 citations

Further characterisation of the in situ terminal deoxynucleotidyl transferase (TdT) assay for the flow cytometric analysis of apoptosis in drug resistant and drug sensitive leukaemic cells

1995 • 64 citations

Constitutive expression of p53 protein in enriched normal human marrow blast cell populations [see comments]

1992 • 53 citations

Biological Features of Leukaemic Cells Associated with Autonomous Growth and Reduced Survival in Acute Myeloblastic Leukaemia

1995 • 38 citations

Expression of different conformations of p53 in the blast cells of acute myeloblastic leukaemia is related to in vitro growth characteristics

1993 • 32 citations

Flow cytometric determination of apoptosis in heterogeneous cell populations

1995 • 23 citations

Levels of mdr1 and mrp mRNA in leukaemic cell populations from patients with acute myelocytic leukaemia are heterogenous and inversely correlated to cellular daunorubicin accumulation

1996 • 20 citations