Possible Mechanism for in Vitro Complement Activation in Blood and Plasma Samples: Futhan/EDTA Controls in Vitro Complement Activation

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

A second serine protease associated with mannan-binding lectin that activates complement

1997 • 827 citations

Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase

1970 • 509 citations

Anaphylatoxins: C3a and C5a

1978 • 502 citations

ISOLATION OF A FRAGMENT (C3a) OF THE THIRD COMPONENT OF HUMAN COMPLEMENT CONTAINING ANAPHYLATOXIN AND CHEMOTACTIC ACTIVITY AND DESCRIPTION OF AN ANAPHYLATOXIN INACTIVATOR OF HUMAN SERUM

1969 • 430 citations

MORTALITY OF SHIPHAM RESIDENTS: 40-YEAR FOLLOW-UP

1982 • 392 citations

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.

1995 • 367 citations

Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.

1996 • 336 citations

New synthetic inhibitors of C1r̄, C1 esterase, thrombin, plasmin, kallikrein and trypsin

1981 • 299 citations

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates.

1986 • 267 citations

Elevated plasma levels of the anaphylatoxins C3a and C4a are associated with a fatal outcome in sepsis

1989 • 218 citations

Complement

1969 • 175 citations

Defensins promote fusion and lysis of negatively charged membranes

1993 • 150 citations

THE SIGNIFICANCE OF SERUM COMPLEMENT LEVELS FOR THE DIAGNOSIS AND PROGNOSIS OF ACUTE AND SUBACUTE GLOMERULONEPHRITIS AND LUPUS ERYTHEMATOSUS DISSEMINATUS

1960 • 132 citations

Circulating complement proteins in multiple trauma patients-Correlation with injury severity, development of sepsis, and outcome

1997 • 129 citations

Inhibitory Effect of a New Synthetic Protease Inhibitor (FUT-175) on the Coagulation System

1985 • 122 citations

A functional model of the human C1 complex

1987 • 121 citations

Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome

1990 • 119 citations

Anaphylatoxin Generation in Multisystem Organ Failure

1984 • 115 citations

Pharmacological Studies of FUT-175, Nafamostat Mesilate V. Effects on the Pancreatic Enzymes and Experimental Acute Pancreatitis in Rats

1986 • 114 citations

Assessment of disease activity and impending flare in patients with systemic lupus erythematosus. Comparison of the use of complement split products and conventional measurements of complement

1992 • 109 citations

The effects of soluble recombinant complement receptor 1 on complement-mediated experimental glomerulonephritis.

1995 • 105 citations

EFFECT OF COBRA VENOM-INDUCED INHIBITION OF COMPLEMENT ACTIVITY ON ALLOGRAFT AND XENOGRAFT REJECTION REACTIONS1

1967 • 102 citations

The complement system in xenotransplantation

1992 • 89 citations

Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome

1996 • 87 citations

Kinetics of reaction of human C-inhibitor with the human complement system proteases Cr and Cs

1980 • 85 citations

Anaphylatoxin-mediated regulation of the immune response. I. C3a-mediated suppression of human and murine humoral immune responses.

1982 • 80 citations

Activation of the C4 and C2 components of complement by a proteinase in serum bactericidal factor, Ra reactive factor.

1993 • 72 citations

New synthetic inhibitor to the alternative complement pathway.

1983 • 71 citations

Anaphylatoxin-mediated regulation of the immune response. II. C5a-mediated enhancement of human humoral and T cell-mediated immune responses.

1983 • 68 citations

The C5a Receptor of Neutrophils and Macrophages

1983 • 47 citations

Inhibition of Various Immunological Reactions in vivo by a New Synthetic Complement Inhibitor

1982 • 47 citations

Mechanisms of Leukocyte Regulation by Complement-Derived Factors

1984 • 39 citations

Elevated plasma C3 anaphylatoxin levels in rheumatoid arthritis patients

1987 • 28 citations

C1q and Mannose-Binding Lectin

1998 • 19 citations

Complement activation in renal allograft recipients.

1992 • 18 citations

Biological functions of the complement system.

1986 • 15 citations

Complement inhibition by amidines and guanidines—in vivo and in vitro results

1978 • 10 citations

Distinct proteolytic activities of MASP-1 and MASP-2

1998 • 9 citations