Mechanisms of Leukocyte Regulation by Complement-Derived Factors

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

1962 • 2,726 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

LEUKOCYTE LOCOMOTION AND CHEMOTAXIS

1973 • 1,709 citations

Chemotaxis Under Agarose: A New and Simple Method for Measuring Chemotaxis and Spontaneous Migration of Human Polymorphonuclear Leukocytes and Monocytes

1975 • 1,190 citations

Complement Activation during Cardiopulmonary Bypass

1981 • 1,163 citations

Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.

1978 • 1,117 citations

Complement and Leukocyte-Mediated Pulmonary Dysfunction in Hemodialysis

1977 • 1,014 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

Further Characterization of the Human Inducer T Cell Subset Defined by Monoclonal Antibody

1979 • 610 citations

Chemotactic response to human C3a and C5a anaphylatoxins. I. Evaluation of C3a and C5a leukotaxis in vitro and under stimulated in vivo conditions.

1978 • 567 citations

ASSOCIATION OF COMPLEMENT ACTIVATION AND ELEVATED PLASMA-C5a WITH ADULT RESPIRATORY DISTRESS SYNDROME

1980 • 561 citations

Medical Treatment of Osteoarthritis

1965 • 554 citations

Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes.

1978 • 512 citations

Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase

1970 • 509 citations

Anaphylatoxins: C3a and C5a

1978 • 502 citations

THE DERIVATION OF TWO DISTINCT ANAPHYLATOXIN ACTIVITIES FROM THE THIRD AND FIFTH COMPONENTS OF HUMAN COMPLEMENT

1968 • 460 citations

ISOLATION OF A FRAGMENT (C3a) OF THE THIRD COMPONENT OF HUMAN COMPLEMENT CONTAINING ANAPHYLATOXIN AND CHEMOTACTIC ACTIVITY AND DESCRIPTION OF AN ANAPHYLATOXIN INACTIVATOR OF HUMAN SERUM

1969 • 430 citations

THE ROLE OF SERUM COMPLEMENT IN CHEMOTAXIS OF LEUKOCYTES IN VITRO

1965 • 404 citations

Chemotaxis and inflammation

1974 • 397 citations

Chemotactic Response to Human C3a and C5a Anaphylatoxins

1978 • 393 citations

Chemotaxis and Inflammation

1974 • 353 citations

Granulocyte Chemotaxis: An Improved in Vitro Assay Employing 51Cr-Labeled Granulocytes

1973 • 328 citations

A Neutrophil Chemotactic Factor from Human C′5

1969 • 297 citations

Human Mononuclear Leukocyte Chemotaxis: A Quantitative Assay for Humoral and Cellular Chemotactic Factors

1972 • 290 citations

Release of histamine from rat mast cells by the complement peptides C3a and C5a.

1975 • 290 citations

Chemotactic and Anaphylatoxic Fragment Cleaved from the Fifth Component of Guinea Pig Complement

1968 • 283 citations

Biological effects of the human complement fragments C5a and C5ades Arg on neutrophil function

1980 • 265 citations

A PLASMIN-SPLIT FRAGMENT OF C'3 AS A NEW CHEMOTACTIC FACTOR

1967 • 264 citations

Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

1978 • 253 citations

The reticuloendothelial system: A comprehensive treatise

1984 • 224 citations

Further studies on the chemotactic factor of complement and its formation in vivo.

1966 • 222 citations

INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE

1968 • 220 citations

Induction of interleukin 1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors.

1982 • 217 citations

FORMATION OF C3a AND C5a ANAPHYLATOXINS IN WHOLE HUMAN SERUM AFTER INHIBITION OF THE ANAPHYLATOXIN INACTIVATOR

1973 • 204 citations

Leukocyte chemotaxis : methods, physiology, and clinical implications

1978 • 201 citations

X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect.

1975 • 200 citations

Partial characterization of human C5a anaphylatoxin. I. Chemical description of the carbohydrate and polypeptide prtions of human C5a.

1976 • 185 citations

The structural basis for anaphylatoxin and chemotactic functions of C3a, C4a, and C5a.

1981 • 185 citations

Defective Regulation of Inflammatory Mediators in Hodgkin's Disease

1974 • 180 citations

Neutrophil Aggregation and Swelling Induced by Chemotactic Agents

1977 • 166 citations

Complement activation and pulmonary leukotasis during nylon fiber filtration leukapheresis

1978 • 159 citations

Granulocyte aggregation as a manifestation of membrane interactions with complement: possible role in leukocyte margination, microvascular occlusion, and endothelial damage.

1979 • 155 citations

A neutrophil chemotatic factor derived from C'5 upon interaction of guinea pig serum with endotoxin.

1969 • 154 citations

Leukotriene B₄: A highly potent and stereospecific factor stimulating migration of polymorphonuclear leukocytes

1980 • 150 citations

Interaction of leukocyte chemotactic factors with the cell surface. I. Chemotactic factor-induced changes in human granulocyte surface charge.

1975 • 148 citations

Cellular and Humoral Mechanisms in Anaphylaxis and Allergy.

1970 • 143 citations

Human plasma carboxypeptidase N. Isolation and characterization.

1978 • 141 citations

Chemotactic Factor Inactivator in Normal Human Serum

1973 • 140 citations

Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation.

1983 • 137 citations

Human C5a and C5a analogs as probes of the neutrophil C5a receptor

1980 • 134 citations

Crystal Structure Analysis and Molecular Model of Human C3a Anaphylatoxin

1980 • 133 citations

A modified method for chemotaxis under agarose

1979 • 131 citations

Role of cell surface contact in the kinetics of superoxide production by granulocytes.

1983 • 126 citations

Complement-Mediated Release of Histamine from Human Leukocytes

1975 • 125 citations

Release of leukotrienes from guinea pig lung stimulated by C5ades Arg anaphylatoxin.

1982 • 124 citations

Chemotactic factor influences on the aggregation, swelling, and foreign surface adhesiveness of human leukocytes.

1978 • 124 citations

Role of Complement in the Induction of Immunological Responses

1976 • 124 citations

Anaphylatoxin-induced histamine release with human leukocytes: studies of C3a leukocyte binding and histamine release.

1979 • 122 citations

A Simple In Vitro Method for Studies on Chemotaxis

1974 • 118 citations

Design of potent and specific inhibitors of carboxypeptidases A and B

1979 • 117 citations

C3e: An Acidic Fragment of Human C3 with Leukocytosis-Inducing Activity

1979 • 115 citations

Anaphylatoxin Generation in Multisystem Organ Failure

1984 • 115 citations

C3 LEUKOTACTIC FACTORS PRODUCED BY A TISSUE PROTEASE

1969 • 114 citations

In Vitro Responses of CBA/N Mice: Spleen Cells of Mice with an X-Linked Defect that Precludes Immune Responses to Several Thymus-Independent Antigens Can Respond to TNP-Lipopolysaccharide

1976 • 113 citations

INDUCTION OF GUINEA PIG B-CELL LYMPHOKINE SYNTHESIS BY MITOGENIC AND NONMITOGENIC SIGNALS TO Fc, Ig, AND C3 RECEPTORS

1974 • 112 citations

Partial Characterization of Human C5a Anaphylatoxin

1976 • 104 citations

A Neutrophil Chemotactic Factor Derived from C′5 upon Interaction of Guinea Pig Serum with Endotoxin

1969 • 101 citations

Complement-induced histamine release from human basophils. II. Mechanism of the histamine release reaction.

1976 • 101 citations

Two Distinct Chemotactic Factor Inactivators in Human Serum

1975 • 97 citations

COMPLEMENT-DEPENDENT B-CELL ACTIVATION BY COBRA VENOM FACTOR AND OTHER MITOGENS?

1974 • 95 citations

Suppression of T lymphocyte functions by human C3 fragments. I. Inhibition of human T cell proliferative responses by a kallikrein cleavage fragment of human iC3b.

1983 • 93 citations

Induction of lymphokine production by EAC and of blastogenesis by soluble mitogens during human B-cell activation

1974 • 92 citations

Stimulation of murine B lymphocytes by isolated C3b.

1975 • 90 citations

Chemotaxis of Basophils by Lymphocyte-Dependent and Lymphocyte-Independent Mechanisms

1975 • 88 citations

Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a).

1973 • 88 citations

Complement-induced histamine release from human basophils. I. Generation of activity in human serum.

1975 • 86 citations

Potentiation of the anaphylatoxins in vivo using an inhibitor of serum carboxypeptidase N (SCPN). I. Lethality and pathologic effects on pulmonary tissue.

1983 • 85 citations

Defective regulation of chemotaxis in cirrhosis.

1975 • 83 citations

Lung inflammation induced by complement-derived chemotactic fragments in the alveolus.

1980 • 83 citations

The active site of C3a anaphylatoxin.

1980 • 82 citations

Leucocyte mobilizing factor: A new biological activity derived from the third component of complement

1972 • 82 citations

Leukotactic Dysfunction in Sarcoidosis

1976 • 81 citations

Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin.

1977 • 80 citations

Anaphylatoxin-mediated regulation of the immune response. I. C3a-mediated suppression of human and murine humoral immune responses.

1982 • 80 citations

Defective leukotaxis in patients with lepromatous leprosy.

1976 • 75 citations

Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: Evidence of a modulator role for the oligosaccharide unit in human des-Arg ⁷⁴ -C5a

1981 • 73 citations

Response of human neutrophils to C5a: a role for the oligosaccharide moiety of human C5ades Arg-74 but not of C5a in biologic activity.

1981 • 70 citations

Complement-Induced Histamine Release from Human Basophils

1976 • 70 citations

Anaphylatoxin-mediated regulation of the immune response. II. C5a-mediated enhancement of human humoral and T cell-mediated immune responses.

1983 • 68 citations

Potentiation of complement (C5a)-induced granulocyte aggregation by cytochalasin B.

1978 • 68 citations

Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents.

1977 • 66 citations

Circular dichroism of C3a anaphylatoxin. Effects of pH, heat, guanidinium chloride, and mercaptoethanol on conformation and function.

1975 • 64 citations

Micropore filter assay of human granulocyte locomotion: Problems and solutions

1978 • 63 citations

Complement-Induced Histamine Release from Human Basophils

1975 • 59 citations

[36] Human plasma carboxypeptidase N

1981 • 57 citations

Influence of Inhibitors of Cellular Function on Chemotactic Factor-Induced Neutrophil Aggregation

1977 • 55 citations

Regulation of Fc fragment-induced murine spleen cell proliferation.

1980 • 54 citations

Quantitation of leukotaxis in agarose by three different methods

1978 • 52 citations

Inhibition of Lymphocyte Blastogenesis by C3c and C3d

1979 • 50 citations

Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes.

1981 • 49 citations

Amino acid sequence of the anaphylatoxin from the fifth component of porcine complement.

1980 • 48 citations

Basophil Chemotaxis: Augmentation by a Factor from Stimulated Lymphocyte Cultures

1973 • 46 citations

Potentiation of the primary humoral immune response in vitro by C5a anaphylatoxin.

1982 • 46 citations

Interaction of Soluble C3 Fragments with Guinea Pig Lymphocytes. Comparison of Effects of C3a, C3b, C3c, and C3d on Lymphokine Production and Lymphocyte Proliferation

1976 • 45 citations

The third component of complement inhibits human lymphocyte blastogenesis.

1981 • 45 citations

Polyclonal activation of murine B lymphocytes by Fc fragments. I. The requirement for two signals in the generation of the polyclonal antibody response induced by Fc fragments.

1980 • 45 citations

Complement fragments suppress lymphocyte immune responses

1982 • 44 citations

Anaphylatoxin from the fifth component of porcine complement. Purification and partial chemical characterization.

1979 • 42 citations

Biochemistry and Biology of a Leucotactic Binary Serum Peptide System Related to Anaphylatoxin

1972 • 42 citations

Inhibition by C3 fragments of C3-dependent rosette formation and antigen-induced lymphocyte transformation.

1974 • 41 citations

The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells.

1979 • 40 citations

The aggregation of rabbit polymorphonuclear leukocytes (PMN's). Effects of agents which affect the acute inflammatory response and correlation with secretory activity

1977 • 37 citations

Leukocyte aggregation induced by chemotactic factors

1978 • 37 citations

Modulation of human lymphocyte function by C3a and C3a(70-77).

1982 • 35 citations

Chemotactic activity of C5ades Arg: Evidence of a requirement for an anionic peptide ‘helper factor’ and inhibition by a cationic protein in serum from patients with systemic lupus erythematosus

1980 • 35 citations

Fc fragment activation of T lymphocytes. I. Fc fragments trigger Lyt 1+23- T lymphocytes to release a helper T cell-replacing activity.

1981 • 32 citations

Studies of immunosuppression by cobra venom factor. I. On early IgG and IgM responses to sheep erythrocytes and DNP-protein conjugates.

1978 • 31 citations

Human C3a-mediated suppression of the immune response. I. Suppression of murine in vitro antibody responses occurs through the generation of nonspecific Lyt-2+ suppressor T cell.

1985 • 31 citations

Chemical Aspects of the Serum Anaphylatoxins

1978 • 31 citations

Evaluation of the Role of C4 in the Cellular Immune Response in Vitro

1979 • 29 citations

Studies on immunosuppression by cobra venom factor. III. On early responses to sheep erythrocytes in C5-deficient mice.

1978 • 28 citations

Role of C3 in the regulation of a splenic PFC response in rabbits.

1980 • 28 citations

Biology of leukotaxis

2006 • 27 citations

Isolation and characterization of an acidic chemotactic factor from complement-activated human serum

1980 • 25 citations

The Chemotactic Factor Inactivator in Normal Human Serum

1973 • 25 citations

Inhibition of secondary in vitro antibody responses by the third component of complement.

1982 • 24 citations

Immunosuppression by cobra factor: Distribution, antigen-induced blast transformation and trapping of lymphocytes during in vivo complement depletion

1976 • 22 citations

Studies of Immunosuppression by Cobra Venom Factor

1978 • 21 citations

Polyclonal activation of murine B lymphocytes by Fe fragments. II. Replacement of T cells by a soluble helper T cell-replacing factor (TRF).

1980 • 20 citations

Molecular aspects of the serum chemotactic factors.

1979 • 16 citations

Contraction of guinea pig lung by synthetic oligopeptides related to human C3a

1984 • 16 citations

Regulation of B lymphocyte activation by the Fc portion of immunoglobulin

1980 • 15 citations

Human C3a-mediated suppression of the immune response

1985 • 14 citations

Suppression of humoral immune responses by synthetic C3a peptides.

1983 • 14 citations

Uptake of 125I-labelled C3a by cultured human endothelial cells.

1979 • 13 citations

Isolation and Characterization of a New and Highly Active form of C5a Anaphylatoxin from Epsilon-Aminocaproic Acid-Containing Porcine Serum

1973 • 13 citations

Interaction of human anaphylatoxin C3a with rat mast cells demonstrated by immunofluorescence

1974 • 12 citations

BIOACTIVE FACTORS OF THE BLOOD COMPLEMENT SYSTEM

1982 • 9 citations

Polymorphonuclear Leucocyte Chemotaxis: Detection of the Gradient and Development of Cell Polarity

1980 • 8 citations

Activation of T lymphocytes by the Fc portion of immunoglobulin

1980 • 7 citations

Possible Involvement of C3 During Stimulation of B Lymphocytes

1975 • 3 citations