Megabase pair deletions in mutant mammalian cells following exposure to amsacrine, an inhibitor of DNA topoisomerase II.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

High-Resolution Mapping of Human Chromosome 11 by in Situ Hybridization with Cosmid Clones

1990 • 1,357 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Important Advances in Oncology

1991 • 768 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

1989 • 448 citations

Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus

1986 • 436 citations

Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene

1990 • 264 citations

Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung

1987 • 233 citations

A structural analysis of the role of the nuclear matrix and DNA loops in the organization of the nucleus and chromosome

1984 • 220 citations

Secondary Leukemia Associated With a Conventional Dose of Etoposide: Review of Serial Germ Cell Tumor Protocols

1993 • 216 citations

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1989 • 206 citations

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

1990 • 181 citations

Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.

1985 • 174 citations

Measurement of mutagenesis in mammalian cells.

1979 • 136 citations

Chrysotile fiber is a strong mutagen in mammalian cells.

1992 • 122 citations

Genetics of Somatic Mammalian Cells: Lethal Antigens as Genetic Markers for Study of Human Linkage Groups

1971 • 121 citations

Measurement of low levels of x-ray mutagenesis in relation to human disease.

1986 • 110 citations

Report of the committee on the genetic constitution of chromosome 11

1990 • 98 citations

Long range physical map of the Wilms' tumor-aniridia region on human chromosome 11

1988 • 91 citations

Molecular aspects of chemical mutagenesis in L5178Y/tk+/− mouse lymphoma cells

1990 • 75 citations

Chromosome aberrations induced by etoposide (VP‐16) are not random

1990 • 73 citations

Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci

1989 • 73 citations

Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains

1989 • 69 citations

Bacteriophage T4 DNA topoisomerase mediates illegitimate recombination in vitro.

1986 • 62 citations

Comparison of the mutagenic and clastogenic activity of amsacrine and other DNA-intercalating drugs in cultured V79 Chinese hamster cells.

1984 • 61 citations

Topoisomerase II as a target of anticancer drug action in mammalian cells.

1987 • 43 citations

Effects of dimethyl sulfoxide and thiourea upon intercalator-induced DNA single-strand breaks in mouse leukemia (L1210) cells.

1983 • 41 citations

Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase

1987 • 41 citations

Altered function of DNA topoisomerases as a basis for antineoplastic drug action.

1988 • 29 citations

DNA Topoisomerase-Mediated Illegitimate Recombination

1994 • 26 citations

Abrogation by novobiocin of cytotoxicity due to the topoisomerase II inhibitor amsacrine in Chinese hamster cells.

1990 • 22 citations

Analysis of human chromosome 11 by somatic cell genetics: Reexamination of derivatives of human-hamster cell line J1

1987 • 19 citations

14 Anticancer Drugs That Convert DNA Topoisomerases into DNA Damaging Agents

1990 • 19 citations

Mutational Analysis in Cultured Human-Hamster Hybrid Cells

1983 • 18 citations

Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells

1991 • 17 citations

Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol.

1991 • 16 citations

Bacterial and mammalian cell mutagenesis, sister‐chromatid exchange, and mouse lung adenoma bioassay with the antineoplastic acridine derivative amsacrine

1984 • 16 citations

Structural aspects of mammalian DNA replication: topoisomerase II.

1987 • 8 citations

The use of human repetitive DNA to target selectable markers into only the human chromosome of a human-hamster hybrid cell line (AL)

1992 • 8 citations