In vitro mutagenesis of the herpes simplex virus type 1 DNA polymerase gene results in altered drug sensitivity of the enzyme

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Transformation of yeast by a replicating hybrid plasmid

1978 • 1,362 citations

Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae

1984 • 955 citations

Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

1988 • 405 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Related functional domains in virus DNA polymerases.

1987 • 243 citations

A method for identifying the viral genes required for herpesvirus DNA replication.

1986 • 228 citations

DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein

1985 • 213 citations

Human DNA polymerase α: predicted functional domains and relationships with viral DNA polymerases

1989 • 201 citations

Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition.

1988 • 190 citations

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1985 • 172 citations

Sequence and transcription analysis of the human cytomegalovirus DNA polymerase gene

1987 • 170 citations

DNA polymerase I gene of Saccharomyces cerevisiae: nucleotide sequence, mapping of a temperature-sensitive mutation, and protein homology with other DNA polymerases.

1988 • 168 citations

Nonstructural proteins of herpes simplex virus. I. Purification of the induced DNA polymerase

1977 • 152 citations

A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens

1984 • 150 citations

Properties of Herpes simplex virus type 1 and type 2 DNA polymerase

1980 • 117 citations

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

1985 • 113 citations

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus

1984 • 102 citations

Physical and genetic analysis of the herpes simplex virus DNA polymerase locus

1980 • 101 citations

Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.

1982 • 100 citations

Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors

1985 • 84 citations

A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin

1987 • 69 citations

Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells.

1987 • 67 citations

Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities

1985 • 59 citations

The Herpes Simplex Virus Type 1 DNA Polymerase Gene: Site of Phosphonoacetic Acid Resistance Mutation in Strain Angelotti is Highly Conserved

1987 • 48 citations

Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir

1986 • 42 citations

Expression of herpes simplex virus type 1 DNA polymerase in Saccharomyces cerevisiae and detection of virus-specific enzyme activity in cell-free lysates

1988 • 41 citations

Inhibition of Herpes simplex virus-induced DNA polymerase, cellular DNA polymerase α, and virus production by aphidicolin

1980 • 37 citations

The herpes simplex virus DNA polymerase: Analysis of the functional domains

1988 • 32 citations

Expression of Rous Sarcoma Virus Transforming Protein pp60^v-src in Saccharomyces cerevisiae Cells

1987 • 26 citations