Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

Insulin and insulin-like growth factor signalling in neoplasia

2008 • 1,927 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Endogenous Sex Hormones and Breast Cancer in Postmenopausal Women: Reanalysis of Nine Prospective Studies

2002 • 1,729 citations

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

2002 • 1,717 citations

The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights

2007 • 989 citations

Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women

2000 • 653 citations

Endogenous Estrogen, Androgen, and Progesterone Concentrations and Breast Cancer Risk Among Postmenopausal Women

2004 • 500 citations

Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition

2005 • 497 citations

Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations.

2002 • 438 citations

Elevated Serum Estradiol and Testosterone Concentrations Are Associated with a High Risk for Breast Cancer

1999 • 409 citations

Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer Among Premenopausal Women

2006 • 381 citations

Serum Insulin-Like Growth Factor I Reference Values for an Automated Chemiluminescence Immunoassay System: Results from a Multicenter Study

2003 • 360 citations

Fasting glucose is a risk factor for breast cancer: a prospective study.

2002 • 350 citations

Serum insulin-like growth factor-I and breast cancer

2000 • 347 citations

6 Factors controlling blood concentration of somatomedin C

1984 • 299 citations

Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer

1993 • 276 citations

Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture.

1984 • 256 citations

Epidemiology of Insulin-like Growth Factor-I in Elderly Men and Women: The Rancho Bernardo Study

1997 • 241 citations

Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in northern and southern Sweden.

2002 • 198 citations

Circulating Levels of Insulin-like Growth Factors, their Binding Proteins, and Breast Cancer Risk

2005 • 183 citations

Genetic and nongenetic factors associated with variation of plasma levels of insulin-like growth factor-I and insulin-like growth factor-binding protein-3 in healthy premenopausal women.

2001 • 183 citations

Insulin-like growth factor I (IGF-I), IGF-binding proteins, and breast cancer.

2002 • 167 citations

IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC)

2006 • 164 citations

Insulin-like growth factor 1 and oestradiol promote cell proliferation of MCF-7 breast cancer cells: new insights into their synergistic effects

2001 • 149 citations

The Association between Diet and Serum Concentrations of IGF-I, IGFBP-1, IGFBP-2, and IGFBP-3 in the European Prospective Investigation into Cancer and Nutrition

2009 • 146 citations

Dietary and Lifestyle Correlates of Plasma Insulin-Like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3): The Multiethnic Cohort

2004 • 144 citations

Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II

2006 • 141 citations

Presence of somatomedin receptors on primary human breast and colon carcinomas

1987 • 141 citations

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and breast cancer risk: eight years on

2006 • 138 citations

Reproducibility of Plasma Steroid Hormones, Prolactin, and Insulin-like Growth Factor Levels among Premenopausal Women over a 2- to 3-Year Period

2006 • 128 citations

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1

2006 • 115 citations

A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk

2005 • 114 citations

Circulating levels of insulin‐like growth factor I, its binding proteins ‐1,‐2, ‐3, C‐peptide and risk of postmenopausal breast cancer

2003 • 109 citations

Age, Sex, and Smoking Are Predictors of Circulating Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor–Binding Protein 3

1999 • 107 citations

Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women.

2003 • 101 citations

Circulating Insulin-Like Growth Factor-I and Binding Protein-3 and the Risk of Breast Cancer

2007 • 97 citations

A cross-sectional study of IGF-I determinants in women

2001 • 93 citations

Association between hepatic steatosis and serum IGF1 and IGFBP-3 levels in a population-based sample

2009 • 83 citations

Nonlinear relationship of insulin-like growth factor (IGF)-I and IGF-I/IGF-binding protein-3 ratio with indices of adiposity and plasma insulin concentrations (Sweden).

2002 • 83 citations

Role of estrogen receptor alpha in modulating IGF-I receptor signaling and function in breast cancer.

2004 • 73 citations

Normal levels of serum IGF-I: determinants and validity of current reference ranges

2007 • 70 citations

Normal Values of Circulating Insulin-Like Growth Factor-I Bioactivity in the Healthy Population: Comparison with Five Widely Used IGF-I Immunoassays

2008 • 66 citations

Body shape throughout life and correlations with IGFs and GH

2007 • 66 citations

Variation in Plasma Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3: Personal and Lifestyle Factors (United States)

2005 • 61 citations

Serum Insulin-Like Growth Factors, Insulin-Like Growth Factor Binding Proteins, and Breast Cancer Risk in Postmenopausal Women

2004 • 56 citations

Insulin-Like Growth Factor-I, IGF Binding Protein-3, and Breast Cancer in Young Women: A Comparison of Risk Estimates Using Different Peptide Assays

2005 • 54 citations

Insulin-Like Growth Factor I Levels in Healthy Adults

2004 • 52 citations

Utility of Insulin-like Growth Factor-1 as a Biomarker in Epidemiologic Studies

2002 • 51 citations

IGF Binding Proteins (IGFBPs) and Regulation of Breast Cancer Biology

2008 • 48 citations

Premenopausal levels of circulating insulin‐like growth factor I and the risk of postmenopausal breast cancer

2005 • 38 citations

The effect of cigarette smoking use and cessation on serum insulin-like growth factors

2004 • 33 citations

Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women

2005 • 31 citations

Pooling Biomarker Data from Different Studies of Disease Risk, with a Focus on Endogenous Hormones

2010 • 30 citations

IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies

2005 • 30 citations

Factors associated with circulating levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in 740 women at risk for breast cancer

2004 • 29 citations

Effects of Alcohol and Menstrual Cycle on Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3

2004 • 24 citations

Nested Case-Control Study of the Association of Circulating Levels of Serum Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 with Breast Cancer in Young Women in Norway

2008 • 23 citations

Circulating Insulin-like Growth Factor (IGF)-I and IGF Binding Protein (IGFBP)-3 Levels and Postmenopausal Breast Cancer Risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) Cohort

2010 • 20 citations

Are mammotropic hormones mainly permissive for the development of breast cancer?

2005 • 12 citations