Progesterone Blockade of Estrogen Activation of μ-Opioid Receptors Regulates Reproductive Behavior

A potent and selective endogenous agonist for the µ-opiate receptor

1997 • 1,306 citations

Anatomy of CNS opioid receptors

1988 • 1,178 citations

CLASSIFICATION OF OPIOID RECEPTORS

1983 • 787 citations

Receptor Endocytosis and Dendrite Reshaping in Spinal Neurons After Somatosensory Stimulation

1995 • 483 citations

Multiple opioid receptors: ligand selectivity profiles and binding site signatures.

1989 • 441 citations

Anatomy of the CNS opioid systems

1985 • 431 citations

Oestrogen modulates progestin receptor concentrations in some rat brain regions but not in others

1978 • 400 citations

Progestin Receptors in Rat Brain: Distribution and Properties of Cytoplasmic Progestin-Binding Sites*

1980 • 342 citations

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.

1998 • 323 citations

Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo.

1995 • 292 citations

Differential distribution of endomorphin 1‐ and endomorphin 2‐like immunoreactivities in the CNS of the rodent

1999 • 277 citations

Opioids and sexual behavior

1987 • 271 citations

Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent

1999 • 247 citations

Chemical Characterization of Neuroendocrine Targets for Progesterone in the Female Rat Brain and Pituitary

1990 • 235 citations

The Temporal Relationship between Estrogen-Inducible Progestin Receptors in the Female Rat Brain and the Time Course of Estrogen Activation of Mating Behavior*

1980 • 229 citations

Estrogen-Induced Alteration of μ-Opioid Receptor Immunoreactivity in the Medial Preoptic Nucleus and Medial Amygdala

1998 • 216 citations

Expression and Estrogen Regulation of Progesterone Receptor mRNA in Neurons of the Mediobasal Hypothalamus: Anin SituHybridization Study

1989 • 203 citations

Estrogen Increases Proenkephalin Messenger Ribonucleic Acid Levels in the Ventromedial Hypothalamus of the Rat

1988 • 180 citations

A Subset of β-Endorphin- or Dynorphin-Containing Neurons in the Medial Basal Hypothalamus Accumulates Estradiol

1985 • 166 citations

Regulation of Progesterone Receptor Messenger Ribonucleic Acid in the Rat Medial Preoptic Nucleus by Estrogenic and Antiestrogenic Compounds: Anin SituHybridization Study

1997 • 158 citations

Postsynaptic Signaling via the μ-Opioid Receptor: Responses of Dorsal Horn Neurons to Exogenous Opioids and Noxious Stimulation

2000 • 149 citations

Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide ActionIn Vivo

1997 • 148 citations

Distribution of opioid peptides in the preoptic region: Immunohistochemical evidence for a steroid‐sensitive enkephalin sexual dimorphism

1988 • 135 citations

Distribution of cells containing progesterone receptor mRNA in the female rat di- and telencephalon: an in situ hybridization study

1992 • 134 citations

Ovarian Steroid Regulation of Estrogen and Progesterone Receptor Messenger Ribonucleic Acid in the Anteroventral Periventricular Nucleus of the Rat

1996 • 131 citations

Induction of estrus: Estrogen-progesterone interactions☆

1968 • 125 citations

Interrelationships between Somatostatin sst2A Receptors and Somatostatin-Containing Axons in Rat Brain: Evidence for Regulation of Cell Surface Receptors by Endogenous Somatostatin

1998 • 121 citations

?-, ?-, and ?-opioid receptor agonists selectively modulate sexual behaviors in the female rat: Differential dependence on progesterone

1992 • 113 citations

Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: A review

1994 • 109 citations

Immunocytochemical mapping of endomorphin-2-immunoreactivity in rat brain

2000 • 106 citations

Estradiol target sites immunoreactive for β-endorphin in the arcuate nucleus of rat and mouse hypothalamus

1986 • 92 citations

Estrogen regulates preproenkephalin-A mRNA levels in the rat ventromedial nucleus: temporal and cellular aspects

1995 • 89 citations

Regulation of lordosis behaviour in the female rat by corticotropin-releasing factor, β-endorphin/corticotropin and luteinizing hormone-releasing hormone neuronal systems in the medial preoptic area

1986 • 84 citations

Endomorphin‐Stimulated [³⁵S]GTPγS Binding in Rat Brain: Evidence for Partial Agonist Activity at μ‐Opioid Receptors

1998 • 71 citations

Selective activation of opioid receptors differentially affects lordosis behavior in female rats

1987 • 70 citations

Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats

1997 • 67 citations

Estrogen Modulation of Opioid and Cholecystokinin Systems in the Limbic-Hypothalamic Circuit

1997 • 56 citations

Injections of cholecystokinin into the ventromedial hypothalamic nucleus inhibit lordosis behavior in the rat

1988 • 55 citations

Endomorphin-1 and endomorphin-2 are partial agonists at the human μ-opioid receptor

1998 • 55 citations

Characterization of endomorphin-1 and -2 on []GTPγS binding in the mouse spinal cord

1998 • 54 citations

Endomorphins fully activate a cloned human mu opioid receptor

1998 • 53 citations

Beta-endorphin suppression of lordosis behavior in female rats; Lack of effect of peripherally-administered naloxone

1984 • 51 citations

Regulation of Progesterone Receptor Messenger Ribonucleic Acid in the Rat Medial Preoptic Nucleus by Estrogenic and Antiestrogenic Compounds: An in Situ Hybridization Study

1997 • 43 citations

Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids.

1993 • 42 citations

Gonadal steroid control of preprocholecystokinin mRNA expression in the limbic‐hypothalamic circuit: Comparison of adult with neonatal steroid treatments

1994 • 41 citations

Dual effect of morphiceptin on lordosis behavior: Possible mediation by different opioid receptor subtypes

1986 • 34 citations

Behavioural specificity of β-endorphin suppression of sexual behavior: differential receptor antagonism

1986 • 32 citations

The effects of intraventricular injection of β-endorphin on initial estrogen action to induce lordosis behavior

1994 • 30 citations

Naloxone and initial estrogen action to induce lordosis in ovariectomized rats: the effect of a cut between the septum and preoptic area

1995 • 29 citations

Influence of opioid peptides on the priming action of estrogen on lordosis in ovariectomized rats

1996 • 28 citations

Opiate receptors modulate estrogen-induced cholecystokinin and tachykinin but not enkephalin messenger RNA levels in the limbic system and hypothalamus

1997 • 25 citations

Differential Effects of β-Endorphin and Met- and Leu-Enkephalin on Steroid Hormone-Induced Lordosis in Ovariectomized Female Rats

1997 • 24 citations

Peripubertal ontogeny and estrogen stimulation of cholecystokinin and preproenkephalin mRNA in the rat hypothalamus and limbic system

1998 • 19 citations

Sex steroid regulation of hypothalamic opioid function

1995 • 18 citations

Ontogeny of Leu-enkephalin and β-endorphin innervation ofthe preoptic area in male and female rats

1993 • 11 citations

Peripubertal ontogeny and estrogen stimulation of cholecystokinin and preproenkephalin mRNA in the rat hypothalamus and limbic system

1998 • 2 citations