Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity
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References (39)
p53 Mutations in Human Cancers
1991 • 8,133 citations
Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines
1991 • 3,158 citations
An Information-Intensive Approach to the Molecular Pharmacology of Cancer
1997 • 1,177 citations
Application of Genetic Function Approximation to Quantitative Structure-Activity Relationships and Quantitative Structure-Property Relationships
1994 • 960 citations
Display and Analysis of Patterns of Differential Activity of Drugs Against Human Tumor Cell Lines: Development of Mean Graph and COMPARE Algorithm
1989 • 943 citations
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
1997 • 872 citations
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
1995 • 491 citations
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
1994 • 410 citations
Neural Computing in Cancer Drug Development: Predicting Mechanism of Action
1992 • 301 citations
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996 • 284 citations
Alkaloids of Ochrosia elliptica Labill.1
1959 • 228 citations
Synthesis of the tumour-inhibitory alkaloids, ellipticine, 9-methoxyellipticine, and related pyrido[4,3-b]carbazoles
1967 • 211 citations
The NCI In Vitro Anticancer Drug Discovery Screen
1997 • 195 citations
Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard
1997 • 153 citations
Intercalative binding of ellipticine to DNA.
1975 • 139 citations
Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents
1997 • 136 citations
National Cancer Institute Drug Information System 3D Database
1994 • 126 citations
Anticancer Specificity of Some Ellipticinium Salts against Human Brain Tumors in vitro
1994 • 115 citations
Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues
1998 • 105 citations
Phenytoin Prodrugs III: Water-Soluble Prodrugs for Oral and/or Parenteral Use
1984 • 100 citations
A protein expression database for the molecular pharmacology of cancer
1997 • 85 citations
Use of the Kohonen Self-organizing Map to Study the Mechanisms of Action of Chemotherapeutic Agents
1994 • 83 citations
Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes.
1996 • 79 citations
Rapid mass spectrometric identification of proteins from two‐dimensional polyacrylamide gels after in gel proteolytic digestion
1997 • 78 citations
Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's drug discovery program for cancer and AIDS
1994 • 71 citations
Design, Synthesis, and Biological Evaluation of Ellipticine−Estradiol Conjugates
1996 • 53 citations
Molecular targets in the National Cancer Institute drug screen
1995 • 46 citations
Discrimination techniques applied to the NCI in vitro anti‐tumour drug screen: Predicting biochemical mechanism of action
1994 • 38 citations
Design, Synthesis, and Study of 9-Substituted Ellipticine and 2-Methylellipticinium Analogs as Potential CNS-Selective Antitumor Agents
1994 • 36 citations
Chapter 7 Synthesis and Antitumor Activity of Ellipticine Alkaloids and Related Compounds
1990 • 31 citations
Design and Synthesis of Ellipticinium Salts and 1,2-Dihydroellipticines with High Selectivities against Human CNS Cancers in vitro
1994 • 28 citations
Cellular Uptake as a Determinant of Cytotoxicity of Quarternalized Ellipticines to Human Brain Tumor Cells
1994 • 18 citations
Uptake and cytotoxicity of 9-methoxy-N2-methylellipticinium acetate in human brain and non-brain tumor cell lines
1995 • 17 citations
Ellipticines
1990 • 10 citations
Synthesis of a series of cytotoxic 2-acyl-1,2-dihydroellipticines which inhibit topoisomerase II.
1996 • 4 citations
Structure-activity relationship study on N-glycosyl moieties through model building of DNA and ellipticine N-glycoside complex
1996 • 3 citations
Genetic function approximation in the molecular pharmacology of cancer
2002 • 2 citations
100 and 50 years ago
1997 • 2 citations
Deleted Work
1955 • 0 citations
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