Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

1985 • 972 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.

1986 • 828 citations

Zinc fingers: Gilt by association

1988 • 799 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

1984 • 504 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line.

1980 • 436 citations

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones.

1983 • 435 citations

Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas

1980 • 427 citations

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

1991 • 357 citations

Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.

1986 • 335 citations

Mitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas

1980 • 314 citations

Molecular Events Mediating T Cell Activation

1990 • 303 citations

T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.

1980 • 289 citations

Expression and Activity of the POU Transcription Factor SCIP

1990 • 244 citations

Drosophila Krüppel protein is a transcriptional represser

1990 • 228 citations

Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.

1985 • 203 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

[25] Purification and fractionation of poly(A)+ RNA

1987 • 190 citations

The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1.

1985 • 189 citations

Interleukin 2 receptor gene expression in normal human T lymphocytes.

1985 • 164 citations

T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.

1985 • 147 citations

Severe Combined Immunodeficiency Due to a Specific Defect in the Production of Interleukin-2

1990 • 146 citations

Signal requirements for T lymphocyte activation. I. Replacement of macrophage function with phorbol myristic acetate.

1979 • 134 citations

Activation of resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes.

1985 • 129 citations

Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression

1986 • 129 citations

The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes

1985 • 120 citations

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

1991 • 108 citations

Recombinant interleukin 2 therapy in severe combined immunodeficiency disease.

1989 • 100 citations

Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone

1987 • 89 citations

Identification, cloning, and characterization of an immune activation gene.

1988 • 88 citations

Independent Molecular Pathways in Initiation and Loss of Hormone Responsiveness of Breast Carcinomas

1988 • 74 citations

T-cell-replacing factor (interleukin 5) induces expression of interleukin 2 receptors on murine splenic B cells.

1987 • 73 citations

Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells.

1987 • 69 citations

Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture.

1992 • 67 citations

Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis

1985 • 63 citations

Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas.

1989 • 45 citations

Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid

1987 • 40 citations

T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications

1990 • 36 citations

Transmission Of Signals From The T Lymphocyte Antigen Receptor To The Genes Responsible For Cell Proliferation And Immune Function: The Missing Link

1990 • 34 citations

XZAP:abacteriophage Xexpression vector withinvivo excision properties

1988 • 15 citations

Mitogenic activation and proliferation of mouse thymocytes

1979 • 13 citations

Human T-Cell Lymphotropic Viruses in Human Diseases

1990 • 8 citations

Deleted Work

1955 • 0 citations