Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer.

Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

1989 • 911 citations

The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group.

1989 • 561 citations

A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

1987 • 452 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.

1981 • 195 citations

Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.

1986 • 162 citations

The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer.

1991 • 106 citations

Enhancement of fluorinated Pyrimidine-Induced Cytotoxicity by Leucovorin in Human Colorectal Carcinoma Cell Lines

1988 • 76 citations

Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.

1987 • 70 citations