When helicase and topoisomerase meet!

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

Supercoiling of the DNA template during transcription.

1987 • 1,909 citations

DNA TOPOISOMERASES

1996 • 1,771 citations

Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family

1997 • 1,751 citations

Positional Cloning of the Werner's Syndrome Gene

1996 • 1,696 citations

The Bloom's syndrome gene product is homologous to RecQ helicases

1995 • 1,371 citations

An atypical topoisomerase II from archaea with implications for meiotic recombination

1997 • 890 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.

1994 • 686 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

DNA topology and its biological effects

1991 • 612 citations

A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase

1989 • 532 citations

The Chromosome of Escherichia coli

1963 • 412 citations

Sgs1: A eukaryotic homolog of E. coil RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation

1995 • 402 citations

DNA topoisomerases: why so many?

1991 • 375 citations

Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers

1980 • 351 citations

The role of topoisomerase IV in partitioning bacterial replicons and the structure of catenated intermediates in DNA replication

1992 • 337 citations

DNA Topoisomerase II Must Act at Mitosis To Prevent Nondisjunction and Chromosome Breakage

1989 • 302 citations

Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA

1984 • 269 citations

Escherichia coli RecQ protein is a DNA helicase.

1990 • 263 citations

The role of DNA topoisomerases in recombination and genome stability: A double-edged sword?

1990 • 236 citations

DNA-binding properties of the yeast SWI/SNF complex

1996 • 195 citations

Helicase-catalyzed DNA unwinding.

1993 • 183 citations

Nucleosome displacement in transcription

1993 • 179 citations

DNA Gyrase and DNA Supercoiling

1979 • 175 citations

The mechanisms of DNA topoisomerases

1995 • 174 citations

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1989 • 174 citations

Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop

1985 • 167 citations

Reverse gyrase: a helicase-like domain and a type I topoisomerase in the same polypeptide.

1993 • 159 citations

DNA replication.

1988 • 130 citations

Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase.

1992 • 127 citations

Interaction of the histone (H3-H4)2 tetramer of the nucleosome with positively supercoiled DNA minicircles: Potential flipping of the protein from a left- to a right-handed superhelical form.

1996 • 117 citations

Purification of the rep protein of Escherichia coli. An ATPase which separates duplex DNA strands in advance of replication.

1978 • 114 citations

In vitro replication through nucleosomes without histone displacement

1990 • 111 citations

Coming undone: How to untangle a chromosome

1994 • 95 citations

Simian Virus 40 Large T Antigen Binds to Topoisomerase I

1996 • 91 citations

Reverse gyrase in thermophilic eubacteria

1991 • 85 citations

ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB.

1991 • 81 citations

Antipairing and strand transferase activities ofE.colihelicase II (UvrD)

1993 • 76 citations

Disruption of a topoisomerase-DNA cleavage complex by a DNA helicase.

1994 • 73 citations

TOPOISOMERASES AND THE SWIVEL PROBLEM

1980 • 72 citations

Aspects of DNA Replication

1979 • 69 citations

5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity*1

1987 • 67 citations

TFIIH: a link between transcription, DNA repair and cell cycle regulation

1995 • 64 citations

Nature and distribution of chromosomal intertwinings in Saccharomyces cerevisiae.

1994 • 64 citations

Unwinding of chromatin by the SV40 large T antigen DNA helicase.

1995 • 55 citations

Reverse gyrase binding to DNA alters the double helix structure and produces single-strand cleavage in the absence of ATP.

1989 • 54 citations

A two-subunit type I DNA topoisomerase (reverse gyrase) from an extreme hyperthermophile.

1996 • 49 citations

The rep Protein of Escherichia coli: Interaction with DNA and Other Proteins

1979 • 42 citations

Dissociation of RecA filaments from duplex DNA by the RuvA and RuvB DNA repair proteins.

1994 • 40 citations

A reverse gyrase with an unusual structure. A type I DNA topoisomerase from the hyperthermophile Methanopyrus kandleri is a two-subunit protein

1994 • 37 citations

New Approaches in Eukaryotic DNA Replication

1983 • 37 citations

Inhibition of protein-mediated homologous pairing by a DNA helicase

1991 • 29 citations

A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity.

1990 • 14 citations

Reverse Gyrase

1995 • 13 citations