The structure and function of human IgA

Immunoglobulin A (IgA): Molecular and Cellular Interactions Involved in IgA Biosynthesis and Immune Response

1987 • 956 citations

Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease

1987 • 634 citations

Selective IgA deficiency: presentation of 30 cases and a review of the literature.

1971 • 515 citations

The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

1984 • 507 citations

Immunoglobulin A: Strategic Defense Initiative at the Mucosal Surface

1986 • 404 citations

IgA-induced eosinophil degranulation.

1989 • 397 citations

Structure of the Carbohydrate Units of IgA1 Immunoglobulin

1974 • 382 citations

Intravascular and Mucosal Immunoglobulin A: Two Separate but Related Systems of Immune Defense?

1987 • 372 citations

Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA

1986 • 313 citations

THE IgA1 PROTEASES OF PATHOGENIC BACTERIA

1983 • 290 citations

IgA subclasses in various secretions and in serum.

1982 • 285 citations

Defense mechanisms involving Fc-dependent functions of immunoglobulin A and their subversion by bacterial immunoglobulin A proteases

1988 • 270 citations

IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans.

1987 • 264 citations

Degradation of immunoglobulins A2, A2, and G by suspected principal periodontal pathogens

1981 • 255 citations

Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils.

1975 • 254 citations

Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.

1986 • 252 citations

Jacalin: an IgA-binding lectin.

1985 • 249 citations

Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans.

1990 • 240 citations

Suppression of leukocyte chemotaxis by human IgA myeloma components.

1976 • 220 citations

GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism

1988 • 219 citations

The Coming of Age of the Immunoglobulin J Chain

1985 • 207 citations

The Hepatic Asialoglycoprotein Recepto

1984 • 185 citations

IgA interaction with the asialoglycoprotein receptor.

1982 • 184 citations

Activation of the alternative pathway of complement by human serum IgA

1987 • 183 citations

The liver and IgA: Immunological, cell biological and clinical implications

1989 • 177 citations

Tissue origins of human polymeric and monomeric IgA.

1982 • 161 citations

Mechanism of neutralization of influenza virus by secretory IgA is different from that of monomeric IgA or IgG.

1985 • 159 citations

Immunology of the lung and upper respiratory tract

1985 • 156 citations

Receptor-mediated binding and uptake of immunoglobulin a by human liver

1988 • 152 citations

The Release of Granule Enzymes from Human Neutrophils Stimulated by Aggregated Immunoglobulins of Different Classes and Subclasses

1972 • 147 citations

[3] Immunoglobulin A (IgA)

1985 • 138 citations

Subpopulations of human peripheral granulocyes and monocytes express receptors for IgA.

1980 • 138 citations

Mechanisms regulating IgA class-specific immunoglobulin production in murine gut-associated lymphoid tissues. II. Terminal differentiation of postswitch sIgA-bearing Peyer's patch B cells.

1983 • 133 citations

Murine Peyer's patch T cell clones. Characterization of antigen-specific helper T cells for immunoglobulin A responses.

1982 • 133 citations

A surface receptor specific for human IgA on group B streptococci possessing the Ibc protein antigen.

1984 • 129 citations

Specificity of opsonic antibodies to enhance phagocytosis of Pseudomonas aeruginosa by human alveolar macrophages.

1975 • 128 citations

Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain.

1979 • 115 citations

Selective IgA Deficiency in Blood Donors

1983 • 110 citations

Inhibitors of leukocyte chemotaxis in alcoholic liver disease

1975 • 110 citations

IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms.

1983 • 109 citations

Suppression by IgA of IgG-mediated phagocytosis by human polymorphonuclear leucocytes.

1978 • 107 citations

Isotype-specific immunoregulation. IgA-binding factors produced by Fc alpha receptor-positive T cell hybridomas regulate IgA responses.

1985 • 104 citations

Cloning and sequencing of the immunoglobulin A1 protease gene (iga) of Haemophilus influenzae serotype b

1989 • 100 citations

Complement‐Fixing Properties of Human IgA Antibodies Alternative Pathway Complement Activation by Plastic‐Bound, But Not Specific Antigen‐Bound, IgA

1989 • 99 citations

Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes.

1982 • 98 citations

The IgA heavy-chain gene family in rabbit: cloning and sequence analysis of 13 C alpha genes.

1989 • 97 citations

Evidence for the Presence of Components of the Alternative (Properdin) Pathway of Complement Activation in Respiratory Secretions

1976 • 96 citations

Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy.

1982 • 92 citations

The interactions of human complement with interfacially aggregated preparations of human secretory IgA

1974 • 90 citations

Receptor for IgA in group A streptococci: cloning of the gene and characterization of the protein expressed in Escherichia coli

1989 • 89 citations

Complex Formation Between Secretory Component and Human Immunoglobulins Related to Their Content of J Chain

1976 • 89 citations

IgA protease of Neisseria gonorrhoeae: isolation and characterization of the gene and its extracellular product.

1984 • 88 citations

Acute lung injury in rat caused by immunoglobulin A immune complexes.

1984 • 88 citations

Jacalin, a jackfruit lectin, precipitates IgA1 but not IgA2 subclass on gel diffusion reaction

1986 • 88 citations

Topography of the combining region of a Thomsen-Friedenreich-antigen-specific lectin jacalin (Artocarpus integrifolia agglutinin). A thermodynamic and circular-dichroism spectroscopic study

1990 • 87 citations

Cytofluorographic analysis of receptors for IgA on human polymorphonuclear cells and monocytes and the correlation of receptor expression with phagocytosis

1983 • 84 citations

Structure of the A2m(1) allotype of human IgA—a recombinant molecule

1979 • 82 citations

Clearance of circulating IgA immune complexes is mediated by a specific receptor on Kupffer cells in mice.

1984 • 82 citations

Characterization of jacalin, the human IgA and IgD binding lectin from jackfruit

1987 • 81 citations

Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration.

1983 • 81 citations

T cell hybridomas coexpressing Fc receptors (FcR) for different isotypes. II. IgA-induced formation of suppressive IgA binding factor(s) by a murine T hybridoma bearing Fc gamma R and Fc alpha R.

1983 • 81 citations

Jacalin: isolation, characterization, and influence of various factors on its interaction with human IgA1, as assessed by precipitation and latex agglutination

1988 • 80 citations

Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy.

1988 • 79 citations

IgA-dependent, monocyte-mediated, antibacterial activity.

1980 • 78 citations

Activation of complement by human serum IgA, secretory IgA and IgA1 fragments

1988 • 76 citations

Site of J Chain Attachment to Human Polymeric IgA

1974 • 75 citations

Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus

1984 • 75 citations

A simple procedure for the isolation of human secretory IgA of IgA1 and IgA2 subclass by a jackfruit lectin, jacalin, affinity chromatography

1987 • 71 citations

The Liver in the IgA Secretory Immune System. Dogs, But Not Rats and Rabbits, Are Suitable Models for Human Studies

1983 • 71 citations

Separation of human IgA1 and IgA2 using jacalin-agarose chromatography

1987 • 71 citations

Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis.

1986 • 69 citations

Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.

1978 • 69 citations

Characterization of the IgA receptor from human polymorphonuclear leucocytes.

1988 • 69 citations

Human IgA as a heterovalent ligand: switching from the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte.

1986 • 67 citations

Ultrastructure of Secretory and High-Polymer Serum Immunoglobulin A of Human and Rabbit Origin

1970 • 66 citations

Clearance kinetics and fate of mouse IgA immune complexes prepared with monomeric or dimeric IgA.

1983 • 66 citations

The expression of receptors for IgA on human monocytes and calcitriol-treated HL-60 cells.

1985 • 64 citations

Relationships between structure and function in the Fc receptor family

1988 • 64 citations

Reduction of phagocytosis, surface hydrophobicity and charge of Salmonella typhimurium 395 MR10 by reaction with secretory IgA (SIgA).

1979 • 63 citations

The binding of human milk lactoferrin to immunoglobulin A

1984 • 63 citations

A novel IgA protease from Clostridium sp. capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins.

1985 • 62 citations

Immunofluorescence analysis of IgA binding by human mononuclear cells in blood and lymphoid tissue.

1989 • 62 citations

Immunochemical Studies on Free and Bound J Chain of Human IgA and IgM

1975 • 59 citations

High serum levels of secretory IgA in liver disease

1982 • 57 citations

Induction of FcR alpha on murine lymphocytes by IgA in vitro.

1982 • 56 citations

Proteus mirabilis strains of diverse type have IgA protease activity

1987 • 53 citations

Regulation of IgA secretion by T cell clones derived from the human gastrointestinal tract.

1988 • 53 citations

Immune response to oral polio vaccine in patients with IgA glomerulonephritis.

1987 • 51 citations

Opsonization of yeast by human serum IgA anti-mannan antibodies and phagocytosis by human polymorphonuclear leucocytes.

1987 • 51 citations

Lack of Opsonization Potential of 11S Human Secretory A

1973 • 51 citations

The specificity of receptors for IgA on human peripheral polymorphonuclear cells and monocytes

1981 • 51 citations

Studies on the specificity of the IgA-binding lectin, jacalin

1988 • 49 citations

Studies on the Opsonic Activity of Human Secretory IgA Using an in Vitro Phagocytosis System

1972 • 48 citations

Cell surface proteins of a group A streptococcus type M4: The IgA receptor and a receptor related to M proteins are coded for by closely linked genes

1989 • 48 citations

IgA in alcoholic cirrhosis.

1983 • 47 citations

Mucosal Immunity: IgA and Polymorphonuclear Neutrophils

1986 • 47 citations

Murine IgA binding factors produced by Fc alpha R(+) T cells: role of Fc gamma R(+) cells for the induction of Fc alpha R and formation of IgA-binding factor in Con A-activated cells.

1984 • 45 citations

IgM, IgG and IgA rheumatoid factors and circulating immune complexes in patients with AIDS and AIDS-related complex with serological abnormalities.

1987 • 45 citations

Altered expression of lymphocyte Fc alpha receptor in selective IgA deficiency and IgA nephropathy.

1983 • 44 citations

Limited diversity of the immunoglobulin A1 protease gene (iga) among Haemophilus influenzae serotype b strains

1988 • 44 citations

Acquired immune hemolytic anemia associated with IgA erythrocyte coating: investigation of hemolytic mechanisms

1984 • 44 citations

Human IgA1 initiates complement-mediated killing of Neisseria meningitidis.

1989 • 44 citations

Lack of complement activation by human IgA immune complexes.

1988 • 44 citations

Immunoglobulin A proteases in gram-negative bacteria isolated from human urinary tract infections

1984 • 43 citations

Virus-specific polymeric immunoglobulin A antibodies in serum from patients with rubella, measles, varicella, and herpes zoster virus infections

1985 • 42 citations

Complement activation in experimental IgA nephropathy: An antigen-mediated process

1987 • 42 citations

Receptors for IgA on a subpopulation of human B lymphocytes.

1979 • 41 citations

Binding of immunoglobulin classes and subclasses to human neutrophils and eosinophils.

1986 • 41 citations

Isotype-specificity of helper T cell clones: Fc alpha receptors regulate T and B cell collaboration for IgA responses.

1984 • 41 citations

Increase of IgA-specific switch T cells in patients with IgA nephropathy.

1989 • 40 citations

Jacalin, the human IgA1 and IgD precipitating lectin, also binds IgA2 of both allotypes

1988 • 40 citations

A protective human monoclonal IgA antibody produced in vitro: Anti‐pneumococcal antibody engendered by Epstein‐Barr virus‐immortalized cell line

1986 • 39 citations

Inhibition of formylmethionyl-leucyl-phenylalanine-stimulated neutrophil chemiluminescence by human immunoglobulin A paraproteins

1981 • 38 citations

Carboxy-terminal structure of the α chain of human IgA [immunoglobulin A] myeloma proteins

1971 • 36 citations

Complement-Dependent Opsonization of Incompatible Erythrocytes by Human Secretory IgA

1972 • 36 citations

Activation of the Classical Complement Pathway by Fc Fragment of Human IgA

1977 • 36 citations

BIOLOGIC FUNCTION OF THE SERUM IgA SYSTEM: MODULATION OF COMPLEMENT‐MEDIATED EFFECTOR MECHANISMS AND CONSERVATION OF ANTIGENIC MASS*

1983 • 35 citations

The site of cleavage in human alpha chains of IgA1 and IgA2:A2m(1) allotype paraproteins by the clostridial IgA protease

1986 • 34 citations

Studies on human secretory immunoglobulin A. IV. Carbohydrate composition.

1972 • 34 citations

Characterization of epitopes of human secretory component on free secretory component, secretory IgA, and membrane-associated secretory component.

1984 • 33 citations

Monocyte superoxide secretion triggered by human IgA.

1989 • 33 citations

Serum factors capable of opsonizing Shigella for phagocytosis by polymorphonuclear neutrophils.

1975 • 33 citations

Solubilization of IgA Immune Precipitates by Complement

1976 • 32 citations

Both Fcα domains of human IgA are involved in in vitro interaction between secretory component and dimeric IgA

1986 • 32 citations

Mixed IgA-IgG aggregates as a model of immune complexes in IgA nephropathy.

1989 • 32 citations

Activation of rat complement by soluble and insoluble rat IgA immune complexes

1988 • 32 citations

[The primary structure of human free secretory component and the arrangement of disulfide bonds].

1984 • 30 citations

Comparative O2-. responses of lung macrophages and blood phagocytic cells in the rat. Possible relevance to IgA immune complex induced lung injury.

1987 • 30 citations

Primary structure of N-glycosidically linked asialoglycans of secretory immunoglobulins from human milk

1984 • 30 citations

A role for the spleen in the appearance of IgM in the bile of rats injected intravenously with horse erythrocytes.

1985 • 28 citations

Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli

1988 • 28 citations

Handling of soluble IgA aggregates by the mononuclear phagocytic system in mice. A comparison with IgG aggregates.

1982 • 27 citations

Murine IgA binding factors (IgA-BF) suppressing IgA production: characterization and target specificity of IgA-BF.

1986 • 26 citations

Genes encoding α-heavy chains of rabbit IgA: characterization of cDNA encoding IgA-g subclass α-chains

1984 • 26 citations

T-cell hybridoma co-expressing Fc receptors for different isotypes. I. Reciprocal regulation of Fc alpha R and Fc gamma R expression by IgA and interferon.

1983 • 26 citations

In vitro activation of rat neutrophils and alveolar macrophages with IgA and IgG immune complexes. Implications for immune complex-induced lung injury.

1987 • 26 citations

Rat C3 Conversion by Rat Anti-2,4, Dinitrophenyl (DNP) Hapten IgA Immune Precipitates

1987 • 25 citations

Receptors for IgA on human lymphocytes—I. Detection and specificity

1981 • 25 citations

A human milk galactosyltransferase is specific for secreted, but not plasma, IgA.

1989 • 25 citations

Antimicrobial Effect of Human Serum IgA

1982 • 25 citations

INHIBITION OF BACTERIAL IgA PROTEASES BY HUMAN SECRETORY IgA AND SERUM*

1983 • 25 citations

Complexes of α1-microglobulin and monomeric IgA in multiple myeloma and normal human sera

1985 • 24 citations

T cell regulation of IgA immunoglobulin production in gut-associated lymphoid tissues

1983 • 23 citations

Surface IgA and Fc-Alpha Receptors on Human Alveolar Macrophages from Normal Subjects and from Patients with Sarcoidosis

1989 • 23 citations

Physical and genetic analysis of DNA regions encoding the immunoglobulin A proteases of different specificities produced by Haemophilus influenzae

1985 • 23 citations

Detection of IgA-class circulating immune complexes (CIC) in sera from patients with IgA nephropathy using a solid-phase anti-C3 Facb enzyme immunoassay (EIA).

1987 • 23 citations

HUMAN COLOSTRAL IgA INTERACTING WITH STAPHYLOCOCCAL PROTEIN A

1976 • 22 citations

The importance of the Fc receptors for IgA in the recognition of IgA by mouse liver cells: its comparison with carbohydrate and secretory component receptors.

1986 • 21 citations

The polymeric immunoglobulin receptor is present on hepatocytes in human liver

1990 • 21 citations

Agglutination of E. coli by secretory IgA--a result of interaction between bacterial mannose-specific adhesins and immunoglobulin carbohydrate?

1988 • 21 citations

The role of the liver in Catabolism of Mouse and Human IgA

1989 • 20 citations

Induction of polymeric IgA rheumatoid factors in infective endocarditis

1983 • 20 citations

The stoichiometry of J chain in human secretory dimeric IgA

1986 • 19 citations

Binding of human IgA1 to rat peritoneal macrophages.

1988 • 18 citations

IgA Binding Factors and Fc Receptors for IgA: Comparative Studies Between IgA and IgE Fc Receptor Systems

1987 • 17 citations

Complexes of albumin and α1-antitrypsin with Fc-fragment of IgA monomer are disulfide-bound to penultimate C-terminal cysteine in the Cα3-domain

1987 • 17 citations

Regulation of the mucosal IgA Response-an Overview

1989 • 16 citations

THE RELATIONSHIP BETWEEN THE COMPLEX OF IMMUNOGLOBULIN A AND ALPHA-1-ANTITRYPSIN, ITS CONSTITUENT COMPONENTS AND THE ACUTE-PHASE RESPONSE AS MEASURED BY C-REACTIVE PROTEIN IN RHEUMATOID ARTHRITIS TREATED WITH GOLD OR D-PENICILLAMINE

1987 • 16 citations

ANTIBODIES TO ESCHERICHIA COLI O ANTIGENS AND THE IN‐VITRO BACTERIOSTATIC PROPERTIES OF HUMAN MILK AND ITS IgA

1983 • 16 citations

Induction of the receptor for the Fc portion of IgA by secretory IgA on human T cell lines and T cell clones

1988 • 15 citations

IgA polymorphism in mice: NZB and BALB/c mice produce two forms of IgA

1983 • 15 citations

Only Tα or Tγ cells can be triggered by IgG or IgA to suppress the production of the matching Ig class

1986 • 15 citations

Expression of receptors for iga on mitogen‐stimulated human t lymphocytes

1988 • 15 citations

Binding of Human IgA Myeloma Proteins to Protein a. Evidence for Different Binding Mechanisms

1982 • 15 citations

Detection of IgAl-Dominant Immune Complexes in Peripheral Blood Polymorphonuclear Leukocytes by Double Immunofluorescence in Patients with IgA Nephropathy

1984 • 15 citations

Inhibition of neutrophil migration by serum IgA from patients with IgA nephropathy.

1982 • 14 citations

Mucosal T Cell Networks: Role of Fc_αR⁺T Cells and Ig BF_αin Regulation of the IgA Response

1987 • 14 citations

Complement-Mediated solubilization of rat IgA immune precipitates☆

1987 • 13 citations

Spontaneous expression of a low affinity Fc receptor for IgA (Fc alpha R) on human B cell lines.

1989 • 12 citations

The activation of C3 and C4 in human serum by immune complexes containing mouse monoclonal antibodies of different isotype and affinity: Effects on solubilisation

1988 • 12 citations

Jacalin: Its binding reactivity with immunoglobulin a from various mammalian species

1988 • 12 citations

RELATIVE RATES OF THE NON-COVALENT AND COVALENT BINDING OF SECRETORY COMPONENT TO AN IgA DIMER

1977 • 11 citations

Binding of Human IgA Fragments to Protein A‐Sepharose Studied with an ELISA Method

1985 • 11 citations

Binding, internalization and degradation of soluble aggregates of human secretory IgA by resident rat peritoneal macrophages.

1988 • 10 citations

Induction of Fc receptors for IgA on murine T cell hybridoma by human monoclonal IgA and by high molecular weight IgA in IgA nephropathy.

1987 • 10 citations

Chromatographic study of the interrelationships of immunoglobulin A and α1-microglobulin in myelomatosis

1985 • 10 citations

THE ABILITY OF IgA TO INHIBIT COMPLEMENT CONSUMPTION BY COMPLEMENT-FIXING ANTIGENS AND ANTIGEN-ANTIBODY COMPLEXES

1984 • 10 citations

Antisera to the secretory component recognize the murine Fc receptor for IgA.

1989 • 10 citations

THE GENETIC CONTROL OF VIRULENCE IN GROUP A STREPTOCOCCI

1983 • 10 citations

Measurement of IgG-α1 anti-trypsin (α1AT) complex in the sera of patients with IgA myelomatosis

1985 • 9 citations

The Fc receptor for IgA expression and affinity on lymphocytes and macrophages

1988 • 9 citations

Recent studies of the interaction of rabbit dimeric IgA with its polymeric immunoglobulin receptor

1988 • 8 citations

Activated Fc Alpha T Cells in Crohn’s Disease are Involved in Regulation of IgA

1988 • 7 citations

Class‐specific suppression of human b cell maturation by iga‐binding factors

1988 • 6 citations

Up-regulation of receptors for IgA on activated human B lymphocytes

1988 • 5 citations

Attachment of polymorphonuclear leukocytes to glomeruli in IgA nephropathy

1983 • 4 citations

IgA protease from Clostridium ramosum that cleaves IgA1 and IgA2, A2m(1): the site of cleavage and digestion of secretory IgA.

1987 • 4 citations

Defective isotype-specific regulation of IgA anti-erythrocyte autoantibody-forming cells in NZB mice.

1989 • 4 citations

IgA nephropathy

1987 • 3 citations

Monoclonal antibody (G6) inhibiting IgA binding to fixed Fc alpha R(+) T2D4 cells. Monoclonal antibody recognizing IgA-binding sites on fixed T2D4 cells.

1988 • 2 citations

Interactions of streptococci with human colostral immunoglobulin A☆

1988 • 2 citations