Clinical Pharmacology of Biguanides

Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy

1994 • 854 citations

International Textbook of Diabetes Mellitus

2003 • 666 citations

Biguanides and NIDDM

1992 • 601 citations

Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

1981 • 477 citations

United Kingdom prospective diabetes study (UKPDS) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years

1995 • 457 citations

Mechanism of Metformin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects*

1991 • 400 citations

Metformin

1995 • 396 citations

Therapeutic Comparison of Metformin and Sulfonylurea, Alone and in Various Combinations: A double-blind controlled study

1994 • 359 citations

Pharmacokinetics of metformin after intravenous and oral administration to man

1979 • 339 citations

International Textbook of Diabetes Mellitus

1993 • 282 citations

Reduction of metformin renal tubular secretion by cimetidine in man.

1987 • 281 citations

Effect of Metformin on Carbohydrate and Lipoprotein Metabolism in NIDDM Patients

1990 • 263 citations

Lactic acidosis in biguanide-treated diabetics

1978 • 254 citations

Cellular Mechanism of Action of Metformin

1990 • 237 citations

Treating insulin resistance in hypertension with metformin reduces both blood pressure and metabolic risk factors

1991 • 223 citations

Acute Antihyperglycemic Mechanisms of Metformin in NIDDM: Evidence for Suppression of Lipid Oxidation and Hepatic Glucose Production

1994 • 217 citations

Disposition of metformin (N,N‐dimethylbiguanide) in man

1978 • 216 citations

New Antidiabetic Drugs

1990 • 213 citations

Vitamin-B12 Status of Patients on Long-term Metformin Therapy

1971 • 210 citations

Metformin Improves Glucose, Lipid Metabolism, and Reduces Blood Pressure in Hypertensive, Obese Women

1993 • 207 citations

Mechanism of Metformin Action in Non-Insulin-Dependent Diabetes

1987 • 184 citations

Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin.

1992 • 177 citations

Metformin for obese, insulin-treated diabetic patients: improvement in glycaemic control and reduction of metabolic risk factors

1993 • 176 citations

Re-evaluation of a biguanide, metformin: mechanism of action and tolerability

1994 • 176 citations

Metformin: a review of its pharmacological properties and therapeutic use.

1979 • 172 citations

Measurement of the renal clearance of drugs.

1981 • 168 citations

Metformin Decreases the High Plasminogen Activator Inhibition Capacity, Plasma Insulin and Triglyceride Levels in Non-Diabetic Obese Subjects

1987 • 166 citations

The Diabetes annual

1985 • 157 citations

The management of non-insulin-dependent diabetes during pregnancy

1985 • 147 citations

Effect of Biguanides on Intestinal Absorption of Glucose

1968 • 143 citations

The impact of metformin therapy on hepatic glucose production and skeletal muscle glycogen synthase activity in overweight type II diabetic patients

1993 • 142 citations

Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy

1983 • 125 citations

Metformin-associated lactic acidosis in Sweden 1977–1991

1993 • 123 citations

Effect of Metformin on Postprandial Lipemia in Patients With Fairly to Poorly Controlled NIDDM

1994 • 122 citations

Metformin in the digestive tract

1988 • 118 citations

Worldwide Experience of Metformin as an Effective Glucose-lowering Agent: A Meta-analysis

1995 • 117 citations

Metformin improves peripheral but not hepatic insulin action in obese patients with type II diabetes

1989 • 116 citations

Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM

1994 • 115 citations

Metformin—An update

1993 • 114 citations

Diarrhea and Metformin in a Diabetic Clinic

1983 • 112 citations

Oral antidiabetic combination therapy with sulphonylureas and metformin.

1991 • 111 citations

COMPARISON OF CHLORPROPAMIDE AND METFORMIN TREATMENT ON WEIGHT AND BLOOD-GLUCOSE RESPONSE OF UNCONTROLLED OBESE DIABETICS

1968 • 107 citations

Effect of Metformin on Insulin-Stimulated Glucose Turnover and Insulin Binding to Receptors in Type II Diabetes

1987 • 105 citations

Metformin Normalizes Nonoxidative Glucose Metabolism in Insulin-Resistant Normoglycemic First-Degree Relatives of Patients With NIDDM

1992 • 105 citations

Biguanides. A review of history, pharmacodynamics and therapy.

1983 • 99 citations

Effect of metformin on peripheral insulin sensitivity in non insulin dependent diabetes mellitus.

1986 • 99 citations

The Effect of Intravenous Metformin on Glucose Metabolism During Hyperglycaemia in Type 2 Diabetes

1992 • 97 citations

Different effects of insulin and oral antidiabetic agents on glucose and energy metabolism in Type 2 (non-insulin-dependent) diabetes mellitus

1989 • 96 citations

The difficult choice of treatment for poorly controlled maturity onset diabetes: tablets or insulin?

1984 • 95 citations

Comparison of metformin and chlorpropamide in non-obese, maturity-onset diabetics uncontrolled by diet.

1977 • 92 citations

One year comparative trial of metformin and glipizide in type 2 diabetes mellitus.

1994 • 92 citations

Metformin increases insulin sensitivity and basal glucose clearance in Type 2 (non‐insulin dependent) diabetes mellitus

1991 • 88 citations

Mechanism of Action of Metformin: Insulin Receptor and Postreceptor Effects in Vitro and in Vivo*

1986 • 86 citations

Antihyperglycaemic Efficacy, Response Prediction and Dose—Response Relations of Treatment with Metformin and Sulphonylurea, Alone and in Primary Combination

1994 • 85 citations

Combined metformin-sulfonylurea treatment of patients with noninsulin-dependent diabetes in fair to poor glycemic control.

1992 • 85 citations

Oral Hypoglycaemic Agents An Update

1984 • 84 citations

Metformin improved insulin resistance in type I, insulin-dependent, diabetic patients

1985 • 82 citations

Metabolic and Hemodynamic Effects of Metformin and Glibenclamide in Normotensive NIDDM Patients

1993 • 81 citations

Lack of effect of intravenous metformin on plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in non-diabetic subjects

1984 • 78 citations

The Effect of Glibenclamide and Metformin on Serum Lipoproteins in Type 2 Diabetes

1988 • 76 citations

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics

1977 • 75 citations

Double-Blind Evaluation of Efficacy and Tolerability of Metformin in NIDDM

1991 • 74 citations

Comparison of Tolbutamide and Metformin in Elderly Diabetic Patients

1990 • 73 citations

Sulphonylurea Failure in Type 2 Diabetes: Treatment with a Basal Insulin Supplement

1987 • 73 citations

Placebo‐controlled Trial of the Effects of Guar Gum and Metformin on Fasting Blood Glucose and Serum Lipids in Obese, Type 2 Diabetic Patients

1990 • 70 citations

Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin.

1991 • 68 citations

Mechanism of metformin action in non-insulin-dependent diabetes

1987 • 68 citations

Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle.

1991 • 65 citations

Biguanides and Sulfonylureas as Combination Therapy in NIDDM

1990 • 60 citations

Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production

1994 • 57 citations

Effect of glycaemic control, metformin and gliclazide on platelet density and aggregability in recently diagnosed type 2 (non-insulin-dependent) diabetic patients.

1989 • 57 citations

Effects of metformin on glucose, insulin and lipid metabolism in patients with mild hypertriglyceridaemia and non-insulin dependent diabetes by glucose tolerance test criteria.

1991 • 56 citations

Study of the effect of metformin on platelet aggregation in insulin-dependent diabetics

1989 • 55 citations

Insulin Receptor Binding to Monocytes, Insulin Secretion, and Glucose Tolerance Following Metformin Treatment: Results of a Double-Blind Cross-Over Study in Type II Diabetics

1983 • 54 citations

KINETIC STUDY OF NORMAL AND SUSTAINED RELEASE DOSAGE FORMS OF METFORMIN IN NORMAL SUBJECTS

1980 • 53 citations

EFFECT OF DIET, SULPHONYLUREAS, AND PHENFORMIN ON PERIPHERAL GLUCOSE UPTAKE IN DIABETES AND OBESITY

1968 • 50 citations

The Influence of Guar Gum on Absorption of Metformin from the Gut in Healthy Volunteers

1989 • 49 citations

Comparison of Combined Therapies in Treatment of Secondary Failure to Glyburide

1992 • 48 citations

Combined metformin-sulfonylurea treatment of patients with noninsulin- dependent diabetes in fair to poor glycemic control

1992 • 46 citations

International Textbook of Diabetes Mellitus

2004 • 46 citations

A prospective study of the effect of 12 months treatment on serum lipids and apolipoproteins A-I and B in type 2 (non-insulin-dependent) diabetes

1982 • 46 citations

Influence of metformin on metabolic effect of insulin in human adipose tissue in vitro.

1984 • 44 citations

Congenital Malformations in Offspring of Diabetic Women Treated with Oral Hypoglycaemic Agents During Embryogenesis

1994 • 43 citations

The Effect of Metformin on Glycaemic Control, Intermediary Metabolism and Blood Pressure in Non‐insulin‐dependent Diabetes Mellitus

1987 • 43 citations

Metformin and glibenclamide: comparative risks.

1984 • 42 citations

Inhibition of Fatty Acid Oxidation by Biguanides: Implications for Metabolic Physiopathology

1974 • 41 citations

The Effects of Metformin on Adipocyte Insulin Action and Metabolic Control in Obese Subjects with Type 2 Diabetes

1989 • 41 citations

Prospective comparative study in NIDDM patients of metformin and glibenclamide with special reference to lipid profiles

1991 • 41 citations

Reduction of the acute bioavailability of metformin by the α‐glucosidase inhibitor acarbose in normal man

1994 • 40 citations

Lactate Turnover and Gluconeogenesis in Obesity: Effect of Phenformin

1970 • 40 citations

Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD.

1991 • 40 citations

Effects of Metformin and Metoprolol CR on Hormones and Fibrinolytic Variables during a Hyperinsulinemic, Euglycemic Clamp in Man

1994 • 38 citations

Metabolic effects of metformin addition to chronic glibenclamide treatment in type 2 diabetes.

1994 • 37 citations

Improvement With Metformin in Insulin Internalizaron and Processing in Monocytes From NIDDM Patients

1990 • 36 citations

Impaired β-cell Responses Improve when Fasting Blood Glucose Concentration is Reduced in Non-insulin-dependent Diabetes

1988 • 35 citations

Metformin and metoprolol CR treatment in non‐obese men

1994 • 34 citations

DEMONSTRATION OF DEFECTIVE GLUCOSE UPTAKE AND STORAGE IN ERYTHROCYTES FROM NON‐INSULIN DEPENDENT DIABETIC PATIENTS AND EFFECTS OF METFORMIN

1993 • 34 citations

Effects of a Biguanide (Metformin) on Vitamin B₁₂and Folic Acid Absorption and Intestinal Enzyme Activities

1971 • 32 citations

Plasma biguanide levels are correlated with metabolic effects in diabetic patients

1987 • 31 citations

METFORMIN ADMINISTRATION IN HYPERLIPIDEMIC STATES

1971 • 30 citations

Treatment with low dose metformin in patients with peripheral vascular disease

1992 • 30 citations

The effects of metformin on the fibrinolytic system in diabetic and non-diabetic subjects.

1991 • 29 citations

Metformin normalizes nonoxidative glucose metabolism in insulin-resistant normoglycemic first-degree relatives of patients with NIDDM

1992 • 29 citations

The influence of dimethylbiguanide on phenprocoumon elimination and its mode of action

1983 • 28 citations

Clinical relevance of biocompatibility.

1994 • 26 citations

Comparative efficacy of metformin and glibenclamide in patients with non-insulin-dependent diabetes mellitus.

1991 • 26 citations

Evolution of Antibodies Anti-PF4/heparin in a Patient with a History of Heparin-induced Thrombocytopenia Reexposed to Heparin

1994 • 26 citations

The hyperlactatemic effect of biguanides: a comparison between phenformin and metformin during a 6-month treatment.

1989 • 26 citations

The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects

1980 • 25 citations

Effects of metformin on haemorheology, lipid parameters and insulin resistance in insulin-dependent diabetic patients (IDDM)

1991 • 25 citations

Insulin receptor binding to monocytes, insulin secretion, and glucose tolerance following metformin treatment. Results of a double-blind cross-over study in type II diabetics

1983 • 24 citations

Effect of oral hypoglycaemic drugs on glucose tolerance and insulin secretion in borderline diabetic patients

1978 • 24 citations

Metformin ameliorates extreme insulin resistance in a patient with anti-insulin receptor antibodies: description of insulin receptor and postreceptor effects in vivo and in vitro

1992 • 24 citations

Metabolic Effects of Combined Sulphonylurea and Metformin Therapy in Maturity-Onset Diabetics

1979 • 22 citations

Effects of metformin and glibenclamide alone and in combination on serum lipids and lipoproteins in patients with non-insulin-dependent diabetes mellitus.

1991 • 22 citations

Energy expenditure in non-insulin dependent diabetic subjects on metformin or sulphonylurea therapy

1987 • 21 citations

Effect of phenformin on hepatic balances of gluconeogenic substrates in man

1978 • 21 citations

Effects of metformin on dyslipoproteinemia in non-insulin-dependent diabetes mellitus.

1991 • 20 citations

Some Effects of Phenethylbiguanide on Human Hepatic Metabolism as Measured by Hepatic Vein Catheterization

1960 • 20 citations

A comparison of treatment with metformin and gliclazide in patients with non-insulin-dependent diabetes

1988 • 20 citations

Short-term effects of metformin on insulin sensitivity and sodium homeostasis in essential hypertensives

1993 • 19 citations

DOUBLE‐BLIND TRIAL OF METFORMIN IN THE THERAPY OF NONKETOTIC DIABETICS

1979 • 19 citations

Effects of metformin treatment on erythrocyte insulin binding in normal weight subjects, in obese non diabetic subjects, in type 1 and type 2 diabetic patients.

1986 • 19 citations

The Use of Human Skeletal Muscle in Vitro for Biochemical and Pharmacological Studies of Glucose Uptake

1973 • 19 citations

Influence of phenformin and metformin on exercise induced lactataemia in patients with diabetes mellitus

1978 • 19 citations

Plasma fibrinogen in diabetes mellitus.

1979 • 18 citations

Biguanides and lactate metabolism: a review.

1973 • 17 citations

Lactic Acidosis during Metformin Treatment in an Elderly Diabetic Patient with Impaired Renal Function

1981 • 16 citations

Diurnal pattern of plasma metformin concentrations and its relation to metabolic effects in type 2 (non-insulin-dependent) diabetic patients.

1990 • 15 citations

Effects of metformin therapy on plasma amino acid pattern in patients with maturity-onset diabetes.

1989 • 15 citations

Defective Hydroxylation of Phenformin as a Determinant of Drug Toxicity

1981 • 14 citations

Influence of metformin on arginine-induced glucagon secretion in human diabetes.

1975 • 14 citations

The insulin sparing effect of metformin in insulin-treated diabetic patients.

1991 • 13 citations

Approche physiopathologique des hyperlactatémies pathologiques chez le diabétique. Intérêt de la metforminémie

1987 • 11 citations

Oxidation of an exogenous glucose load using naturally labelled 13C-glucose

1978 • 10 citations

ORAL HYPOGLYCÆMIC AGENTS

1960 • 9 citations

Improvement with metformin in insulin internalization and processing in monocytes from NIDDM patients

1990 • 8 citations

THE INFLUENCE OF PHENFORMIN ON LACTATE METABOLISM IN DIABETIC PATIENTS IN RELATION TO HYPOXIA AND EXERCISE

1973 • 5 citations

[The effect of biguanides on insulin sensitivity of maturity onset diabetics (author's transl)].

1980 • 2 citations

Cited By (0)

Loading...