Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT_1A and 5‐HT_1B agonists

1987 • 838 citations

A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635

1995 • 610 citations

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

1993 • 607 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices

1983 • 497 citations

Adenylate cyclase assay.

1979 • 485 citations

5-HT1A receptor agonists: recent developments and controversial issues

1995 • 463 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes

1987 • 406 citations

5-HT1A receptor-related anxiolytics

1987 • 402 citations

1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.

1986 • 379 citations

(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists

1986 • 301 citations

Hypothermia in the rat induced by the potent serotoninergic agent 8-OH-DPAT

1985 • 241 citations

Alterations of central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine1A agonists with potential anxiolytic properties.

1988 • 205 citations

Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat

1988 • 186 citations

3H-TVX Q 7821: identification of 5-HT1 binding sites as target for a novel putative anxiolytic

1985 • 174 citations

Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration

1988 • 168 citations

[3H]Para-amino-clonidine: A novel ligand which binds with high affinity to α-adrenergic receptors

1979 • 142 citations

Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821

1984 • 138 citations

Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat?

1995 • 132 citations

Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies.

1990 • 131 citations

Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.

1993 • 129 citations

The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra

1988 • 126 citations

Characterization of the receptor subtype involved in alpha-adrenoceptor-mediated modulation of serotonin release from rat brain cortex slices

1981 • 126 citations

Selectivity of serotonergic drugs for multiple brain serotonin receptors

1987 • 117 citations

Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.

1992 • 105 citations

Alpha noradrenergic receptors in brain membranes: Sodium, magnesium and guanyl nucleotides modulate agonist binding

1979 • 88 citations

Neuroprotective properties of 5-HT1A receptor agonists En rodent models of focal and global cerebral ischemia

1991 • 86 citations

Activation of 5-HT<sub>1A</sub> Receptor Subtype in the Paraventricular Nuclei of the Hypothalamus Induces CRH and ACTH Release in the Rat

1992 • 86 citations

The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro

1992 • 84 citations

5-HT1A Receptors in Anxiety

1991 • 81 citations

Preclinical pharmacology of flesinoxan: A potential anxiolytic and antidepressant drug

1991 • 65 citations

Changes in Anterior Pituitary Hormone Levels after Serotonin 1A Receptor stimulation

1990 • 64 citations

Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT)

1986 • 60 citations

Measurements of adenosine 3′:5′‐cyclic monophosphate and membrane potential in neuroblastoma X glioma hybrid cells: Opiates and adrenergic agonists cause effects opposite to those of postaglandin E₁

1975 • 60 citations

MDL 72832: a potent and stereoselective ligand at central and peripheral 5-HT1A receptors

1988 • 54 citations

Serotonin 5-HT1A Agonists

1994 • 49 citations

S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors.

1992 • 44 citations

New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors.

1993 • 40 citations

Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models.

1996 • 39 citations

Differential receptor reserve for 5-HT1A receptor-mediated regulation of plasma neuroendocrine hormones.

1994 • 37 citations

Inhibition of 8-OH-DPAT-induced elevation of plasma corticotrophin by the 5-HT1A receptor antagonist WAY100635

1994 • 36 citations

Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates

1993 • 36 citations

Preclinical studies on LY228729: a potent and selective serotonin1A agonist.

1993 • 36 citations

Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity.

1994 • 33 citations

Studies on the neuronal circuits involved in the discriminative stimulus effects of 5-hydroxytryptamine1A receptor agonists in the rat.

1993 • 32 citations

The characterization of [3H]sulpiride binding sites in rat striatal membranes

1987 • 31 citations

A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin.

1995 • 31 citations

Differential Sites of Action of 8OH-DPAT, a 5HT1A Agonist, on ACTH and PRL Secretion in the Rat

1995 • 30 citations

The G protein coupling T cell antigen receptor/CD3‐complex and phospholipase C in the human T cell lymphoma Jurkat is not a target for cholera toxin

1990 • 19 citations

Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist.

1994 • 17 citations

Pharmacological characterization of enantiomers of 8‐thiomethyl‐2‐(di‐n‐propylamino)tetralin, potent and selective 5‐HT_1A receptor agonists

1995 • 15 citations

Differentiation of 8-OH-DPAT and Ipsapirone in Rat Models of 5-HT1A Receptor Function

1991 • 13 citations

5-HT1A agonises show neuroprotectant activity in rats and mice

1990 • 12 citations

Signalling via rat dopamine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the sigma sites of these cells

1993 • 3 citations