Dissociation of Tolerance and Dependence for Opioid Peripheral Antinociception in Rats

The Control of Pain in Peripheral Tissue by Opioids

1995 • 733 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors

1974 • 316 citations

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

1993 • 282 citations

The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

1994 • 279 citations

Opiate-dependent modulation of adenylate cyclase.

1977 • 265 citations

Effects of chronic morphine administration on mu opioid receptor- stimulated [35S]GTPgammaS autoradiography in rat brain

1996 • 264 citations

The development of morphine tolerance and dependence is associated with translocation of protein kinase C

1995 • 212 citations

The Effects of NMDA Receptor Antagonists and Nitric Oxide Synthase Inhibitors on Opioid Tolerance and Withdrawal Medication Development Issues for Opiate Addiction

1995 • 197 citations

NG-Nitro-L-arginine prevents morphine tolerance

1992 • 183 citations

Involvement of the mu-opiate receptor in peripheral analgesia

1989 • 172 citations

The contribution of training to sensitivity in the nociceptive paw-withdrawal test

1989 • 163 citations

Inhibition of nitric oxide synthase attenuates the development of morphine tolerance and dependence in mice

1994 • 140 citations

N-Methyl-?-Aspartate (NMDA) Receptors, Mu and Kappa Opioid Tolerance, and Perspectives on New Analgesic Drug Development

1995 • 128 citations

Prostaglandins sensitize nociceptors in cell culture

1991 • 128 citations

Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide

1969 • 116 citations

Nitric Oxide Synthase Inhibitors Preclinical Studies of Potential Use for Treatment of Opioid Withdrawal

1995 • 114 citations

Inhibition of protein kinase C, but not of protein kinase A, blocks the development of acute antinociceptive tolerance to an intrathecally administered μ-opioid receptor agonist in the mouse

1995 • 109 citations

Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal

1995 • 104 citations

Effects of naloxone and D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 and the protein kinase inhibitors H7 and H8 on acute morphine dependence and antinociceptive tolerance in mice.

1996 • 104 citations

DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro

1996 • 92 citations

Increased Density of Guanine Nucleotide-Binding Proteins in the Postmortem Brains of Heroin Addicts

1994 • 89 citations

Perspectives on the N-Methyl-?-Aspartate/Nitric Oxide Cascade and Opioid Tolerance

1995 • 86 citations

Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: A G-protein βγ subunit-mediated effect?

1995 • 61 citations

Attenuation of tolerance to, and physical dependence on, morphine in the rat by inhibition of nitric oxide synthase

1995 • 58 citations

Possible involvement of protein kinases in physical dependence on opioids: studies using protein kinase inhibitors, H-7 and H-8

1995 • 55 citations

The association of neuropathic pain, morphine tolerance and dependence, and the translocation of protein kinase C.

1995 • 54 citations

Peripheral analgesic actions of opioids

1991 • 53 citations

A protein kinase inhibitor, H-7, inhibits the development of tolerance to opioid antinociception

1994 • 51 citations

Effect of spinal infusion of l-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat

1996 • 35 citations

Ca2+ channel blocker, diltiazem, prevents physical dependence and the enhancement of protein kinase C activity by opioid infusion in rats

1995 • 33 citations

Effect of nitric oxide synthase inhibition on tolerance to the analgesic action of D-Pen2, D-Pen5 enkephalin and morphine in the mouse

1996 • 32 citations

Species and age-dependent differences of functional coupling between opioid δ-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes

1994 • 16 citations

The Association of Neuropathic Pain, Morphine Tolerance and Dependence, and the Translocation of Protein Kinase C

1995 • 14 citations

Evidence for functional dissociation of dependence and tolerance in guinea‐pig isolated ileal segments following 20 hour exposure to morphine in vitro

1993 • 8 citations

Modulation of opioid signal transduction in SH-SY5Y neural cells by differentiating agents: Concurrent mu receptor upregulation and effector desensitization by phorbol ester

1994 • 2 citations

[Effects of dietary proteins on analgesic activity of tolerance and physical dependence on morphine in rats].

1992 • 1 citations