Thyroid hormone responsiveness in human growth hormone-related genes. Possible correlation with receptor-induced DNA conformational changes.

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

A novel rapid assay for chloramphenicol acetyltransferase gene expression

1987 • 802 citations

The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein

1988 • 771 citations

The thyroid hormone receptor binds with opposite transcriptional effects to a common sequence motif in thyroid hormone and estrogen response elements

1988 • 679 citations

Depletion of L-3,5,3'-Triiodothyronine and L-Thyroxine in Euthyroid Calf Serum for Use in Cell Culture Studies of the Action of Thyroid Hormone*

1979 • 653 citations

PROTEIN-NUCLEIC ACID INTERACTIONS IN TRANSCRIPTION: A Molecular Analysis

1984 • 620 citations

A simple method for site-directed mutagenesis using the polymerase chain reaction

1989 • 607 citations

The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors

1991 • 603 citations

SEQUENCE-DIRECTED CURVATURE OF DNA

1990 • 490 citations

COUP transcription factor is a member of the steroid receptor superfamily

1989 • 480 citations

The human growth hormone locus: Nucleotide sequence, biology, and evolution

1989 • 475 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

1990 • 430 citations

Thyroid hormone receptor α isoforms generated by alternative splicing differentially activate myosin HC gene transcription

1988 • 425 citations

Structure and Evolution of the Growth Hormone Gene Family

1983 • 402 citations

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

1989 • 387 citations

Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli.

1989 • 356 citations

A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone

1987 • 347 citations

Negative regulation of viral enhancers in undifferentiated embryonic stem cells

1985 • 347 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

Kinked DNA in crystalline complex with EcoRI endonuclease

1984 • 303 citations

A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

1987 • 301 citations

Functional replacement of a protein-induced bend in a DNA recombination site

1989 • 259 citations

Mutations of the Rat Growth Hormone Promoter which Increase and Decrease Response to Thyroid Hormone Define a Consensus Thyroid Hormone Response Element

1989 • 240 citations

Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor.

1987 • 218 citations

Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity

1990 • 208 citations

Importance of DNA stiffness in protein–DNA binding specificity

1987 • 204 citations

Thyroid Hormone Regulates the Mouse Thyrotropin β-Subunit Gene Promoter in Transfected Primary Thyrotropes

1989 • 203 citations

Bending of the bacteriophage lambda attachment site by Escherichia coli integration host factor.

1988 • 196 citations

Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone.

1987 • 183 citations

On the different binding affinities of CRP at thelac, galandmalT promoter regions

1983 • 160 citations

cis-acting elements of the rat growth hormone gene which mediate basal and regulated expression by thyroid hormone.

1987 • 159 citations

Why bend DNA?

1990 • 134 citations

A major thyroid hormone response element in the third intron of the rat growth hormone gene.

1990 • 123 citations

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

1990 • 119 citations

The NF-ϰB transcription factor induces DNA bending which is modulated by its 65-kD subunit

1990 • 109 citations

Rat growth hormone gene expression. Both cell-specific and thyroid hormone response elements are required for thyroid hormone regulation.

1988 • 108 citations

The Drosophila gene knirps-related is a member of the steroid-receptor gene superf amily

1988 • 105 citations

Bending of promoter DNA on binding of heat shock transcription factor

1986 • 101 citations

Thyroid Hormone Regulation of the Rat Glycoprotein Hormone α-Subunit Gene Promoter Activity

1989 • 99 citations

Interaction of thyroid hormone receptors with strong and weak cis-acting elements in the human alpha-myosin heavy chain gene promoter.

1990 • 98 citations

The rat growth hormone gene contains multiple thyroid response elements

1989 • 92 citations

The effect of a lambda repressor mutation on the activation of transcription initiation from the lambda PRM promoter

1983 • 83 citations

The human growth hormone gene is negatively regulated by triiodothyronine when transfected into rat pituitary tumor cells.

1986 • 82 citations

Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human‐growth‐hormone gene

1989 • 77 citations

The thyroid hormone receptor binds to multiple domains of the rat growth hormone 5′-flanking sequence.

1988 • 77 citations

DNA bending is induced by a transcription factor that interacts with the human c-FOS and alpha-actin promoters.

1989 • 72 citations

Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.

1984 • 70 citations

Molecular mechanism of promoter selection in gene transcription. II. Kinetic evidence for promoter search by a one-dimensional diffusion of RNA polymerase molecule along the DNA template.

1982 • 63 citations

Transcription factor IIIA induced bending of the Xenopus somatic 5S gene promoter

1989 • 55 citations

Regulated expression of chimaeric genes containing the 5′-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells

1987 • 55 citations

Tissue-Specific Expression and Thyroid Hormone Regulation of the Endogenous Placental Growth Hormone Variant and Chorionic Somatomammotropin Genes in a Human Choriocarcinoma Cell Line*

1991 • 47 citations

Differential expression of human placental growth-hormone variant and chorionic somatomammotropin in culture

1990 • 43 citations

Large scale purification of the nuclear thyroid hormone receptor from rat liver and sequence-specific binding of the receptor to DNA.

1988 • 42 citations

Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences

1989 • 38 citations

Hormonal Regulation of Expression of the Endogenous and Transfected Human Growth Hormone Gene

1987 • 36 citations

The steroid/thyroid hormone receptor family and gene regulation

1990 • 25 citations

Regulation of human chorionic somatomammotropin gene expression in rat pituitary tumour cells

1988 • 16 citations

Binding of the Glucocorticoid Receptor Induces a Topological Change in Plasmids Containing the Hormone-Responsive Element of Mouse Mammary Tumor Virus

1990 • 13 citations