Antitumor Activity of Corynebacterium Parvum

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

A DIFFERENCE IN THE ARCHITECTURE OF THE SURFACE MEMBRANE OF NORMAL AND VIRALLY TRANSFORMED CELLS

1969 • 549 citations

PASSIVE IMMUNITY AGAINST CHILDHOOD CANCER

1974 • 520 citations

ALTERATIONS OF MACROPHAGE FUNCTIONS BY MEDIATORS FROM LYMPHOCYTES

1971 • 507 citations

LYMPHOPENIA AND CHANGE IN DISTRIBUTION OF HUMAN B AND T LYMPHOCYTES IN PERIPHERAL BLOOD INDUCED BY IRRADIATION FOR MAMMARY CARCINOMA

1972 • 462 citations

Possible Role of Macrophage Mediated Nonspecific Cytotoxicity in Tumour Resistance

1972 • 376 citations

AVIRULENT CORYNEBACTERIA

1975 • 371 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 349 citations

PECULIAR IMMUNOBIOLOGY OF BONE MARROW ALLOGRAFTS

1971 • 343 citations

Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines.

1968 • 336 citations

The role of the reticuloendothelial system in the host reaction to neoplasia

1962 • 295 citations

Heterocytolysis by Macrophages Activated by Bacillus Calmette-Gurin: Lysosome Exocytosis into Tumor Cells

1974 • 278 citations

Inhibition of Tumour Growth by Administration of Killed Corynebacterium parvum

1966 • 270 citations

Cell Wall Composition and Deoxyribonucleic Acid Similarities Among the Anaerobic Coryneforms, Classical Propionibacteria, and Strains ofArachnia propionica

1972 • 269 citations

Differences between the Electrical Charge carried by Normal and Homologous Tumour Cells

1956 • 259 citations

Release of lysosomal protease by ultraviolet irradiation and inhibition by hydrocortisone

1961 • 258 citations

REACTIONS OF NORMAL AND TUMOR CELL SURFACES TO ENZYMES, I. WHEAT-GERM LIPASE AND ASSOCIATED MUCOPOLYSACCHARIDES

1963 • 240 citations

Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts.

1966 • 238 citations

Effects of fat-soluble compounds on lysosomes in vitro

1962 • 238 citations

Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells.

1969 • 219 citations

Biological effects of the adjuvant Corynebacterium parvum

1972 • 205 citations

Biological Sciences: Reflex Balance

1973 • 203 citations

Biological effects of the adjuvant Corynebacterium parvum

1972 • 181 citations

Intercellular Contact and Cell-Surface Galactosyl Transferase Activity

1972 • 178 citations

Tumor Cytotoxicity In Vitro by Macrophages From Mice Infected With Mycobacterium bovis Strain BCG

1974 • 174 citations

THE RETICULOENDOTHELIAL SYSTEM AND THE NEOPLASTIC PROCESS*

1960 • 171 citations

RUBELLA VACCINATION

1973 • 163 citations

Macrophage Nonimmunologic Recognition: Target Cell Factors Related to Contact Inhibition

1973 • 160 citations

Protection of mice againstBabesiaspp. andplasmodiumspp. with killedCorynebacterium parvum

1977 • 146 citations

In vitro inhibition of tumour cell growth and DNA synthesis by peritoneal and lung macrophages from mice injected with corynebacterium parvum

1974 • 139 citations

Active Immunotherapy with Corynebacterium parvum and Chemotherapy in Murine Fibrosarcomas

1970 • 137 citations

Splenic Suppressor Macrophages Induced in Mice by Injection of Corynebacterium Parvum

1975 • 133 citations

Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds

1976 • 125 citations

Corynebacterium parvum as an immunotherapeutic anticancer agent.

1974 • 124 citations

Ability of activated complement components to induce lysosomal enzyme release from macrophages

1976 • 122 citations

The Role of Activated Macrophages in Specific and Nonspecific Cytostasis of Tumor Cells

1974 • 117 citations

Vaccines and cell-mediated immunity.

1974 • 115 citations

Lympho-Reticular Stimulatory Properties of Corynebacterium Parvum and Related Bacteria

1973 • 108 citations

Corynebacterium parvum as a Therapeutic Antitumor Agent in Mice. I. Systemic Effects From Intravenous Injection2

1974 • 106 citations

A kinetic study of antibody producing cells in the spleen of mice immunized intravenously with sheep erythrocytes.

1968 • 105 citations

Enhancement by drugs of metastatic lung nodule formation after intravenous tumour cell injection

1975 • 101 citations

The propionic acid bacteria

1928 • 100 citations

Corynebacterium parvum as a Therapeutic Antitumor Agent in Mice. II. Local Injection 2

1974 • 98 citations

Increased nonspecific resistance to malaria produced by administration of killed Corynebacterium parvum

1967 • 97 citations

Experimental Screening for “Systemic Adjuvants of Immunity” Applicable in Cancer Immunotherapy

1974 • 94 citations

Anti-Tumour Effect In Vitro of Lymphocytes and Macrophages from Mice Treated with Corynebacterium Parvum

1974 • 91 citations

Mechanisms of macrophage activation by Corynebacterium parvum

1975 • 90 citations

The effect of Corynebacterium parvum on the structure and function of the lymphoid system in mice

1974 • 82 citations

Corynebacterium parvum: a Synonym for Propionibacterium acnes?

1974 • 82 citations

ANTIGEN-INDUCED STIMULATION OF GLUCOSAMINE INCORPORATION BY GUINEA PIG PERITONEAL MACROPHAGES IN DELAYED HYPERSENSITIVITY

1972 • 82 citations

Dichotomy between macrophage activation and degree of protection against Listeria monocytogenes and Toxoplasma gondii in mice stimulated with Corynebacterium parvum

1975 • 80 citations

Brief Communication: Daily Intravenous Infusions of Corynebacterium parvum in Twenty Patients With Disseminated Cancer: A Preliminary Report of Clinical and Biologic Findings

1975 • 77 citations

The growth of tumours in T-cell deprived mice and their response to treatment withCorynebacterium parvum

1973 • 76 citations

Suppression of cell-mediated tumour immunity by Corynebacterium parvum

1975 • 75 citations

Biological effects of Corynebacterium parvum

1973 • 75 citations

Biological Effects of Corynebacterium Parvum. III. amplification of resistance and impairment of Active Immunity to Murine Tumours

1972 • 74 citations

Depression of delayed-type hypersensitivity by Corynebacterium parvum: Mandatory role of the spleen

1974 • 73 citations

Macrophage activation and anti‐tumor activity of biologic and synthetic agents

1976 • 73 citations

Experimental cutaneous leishmaniasis. II. Effects of immunosuppression and antigenic competition on the course of infection with Leishmania enriettii in the guinea-pig.

1972 • 71 citations

Effect of Corynebacterium parvum Treatment on the Growth of Salmonella enteritidis in Mice

1974 • 67 citations

Combined chemoimmunostimulation therapy against murine leukemia.

1972 • 66 citations

Further analysis of the anti-tumour effect in vitro of peritoneal exudate cells from mice treated with Corynebacterium parvum

1975 • 63 citations

Tumour growth, phagocytic activity and antibody response in Corynebacterium parvum-treated mice.

1974 • 61 citations

Mechanisms of Antitumor Action of Corynebacterium parvum : Nonspecific Tumor Cell Destruction at Site of an Immunologically Mediated Sensitivity Reaction to C. parvum 2

1975 • 60 citations

Lasting rejection of mammary adenocarcinoma cell tumors in DBA-2 mice with intratumor injection of killed Corynebacterium parvum.

1974 • 58 citations

Antitumour effects of Corynebacterium parvum in mice

1974 • 57 citations

Immunoprophylaxis and immunotherapy for a murine fibrosarcoma with C. Granulosum and C. Parvum

1974 • 56 citations

The mechanism of inhibition by Corynebacterium parvum of the growth of lung nodules from intravenously‐injected tumor cells

1974 • 56 citations

Inhibitory effect of prolongedcorynebacterium parvum and cyclophosphamide administration on the growth of established tumors

1975 • 56 citations

Active specific immunotherapy of mouse methylcholanthrene induced tumours with Corynebacterium parvum and irradiated tumour cells

1975 • 53 citations

Potentiation of the Tumor-Specific Immune Response by Corynebacterium parvum 2

1975 • 53 citations

The role of anaerobic coryneforms on specific and non-specific immunological reactions. I. Effect on particle clearance and humoral and cell-mediated immunological responses.

1973 • 52 citations

Increased incidence of lung metastases following treatment of rats bearing hepatomas with irradiated tumour cells and the benefical effect of Corynebacterium parvum in this system.

1973 • 51 citations

The effect of a single and repeated administration of Corynebacterium parvum on bone marrow macrophage colony production in syngeneic tumor-bearing mice.

1974 • 50 citations

Role of anaerobic coryneforms in specific and non-specific immunological reactions. II. Production of a chemotactic factor specific for macrophages.

1973 • 50 citations

Corynebacterium-induced protection against artificial pulmonary metastases of a syngeneic fibrosarcoma in mice.

1974 • 50 citations

A lipid chemotactic factor from anaerobic coryneform bacteria including Corynebacterium parvum with activity for macrophages and monocytes.

1976 • 47 citations

The effect of nonspecific immune stimulation with corynebacterium parvum on patterns of tumor growth

1970 • 46 citations

Combination of Local Irradiation with Systemic Application of Anaerobic Corynebacteria in Therapy of a Murine Fibrosarcoma

1975 • 46 citations

The effects of Corynebacterium parvum and surgery on the Lewis lung carcinoma and its metastases

1976 • 45 citations

Immunostimulation with Bacterial Phospholipid Extracts

1974 • 45 citations

Observations followingCorynebacterium parvum administration to patients with advanced malignancy.A phase I study

1976 • 43 citations

An experimental model of active immunotherapy preceded by cytoreductive chemotherapy

1970 • 41 citations

Enhancement and depression of the antibody response in mice caused by Corynebacterium parvum.

1974 • 40 citations

Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. I. Description of the phenomenon.

1971 • 40 citations

Activation of the classical and alternate pathways of complement by Corynebacterium parvum.

1975 • 39 citations

Mechanisms of macrophage activation by Corynebacterium parvum

1975 • 38 citations

Further Observations on the Effect of C. parvum and Anti-Tumour Globulin on Syngeneically Transplanted Mouse Tumours

1972 • 37 citations

Nonspecific entry of thoracic duct immunoblasts into intradermal foci of antigens

1973 • 36 citations

Effect of Corynebacterium parvum on the response to irradiation of a C3H fibrosarcoma.

1976 • 36 citations

New High-strength Stainless Steels

1972 • 36 citations

Further Observations on the Inhibition of Tumor Growth by Corynebacterium parvum With Cyclophosphamide. I. Variation in Administration of Both Agents2

1975 • 35 citations

Nonspecific Immunotherapy of Murine Solid Tumors With <italic>Corynebacterium granulosum</italic><xref ref-type="fn" rid="fn2">2</xref>

1975 • 34 citations

Effect of Corynebacterium Parvum on Bone Marrow Cell Cultures

1975 • 34 citations

Specific and nonspecific stimulation of resistance to the growth and metastasis of the line 1 lung carcinoma.

1975 • 33 citations

Effect of local injection of Corynebacterium parvum on the growth of a murine fibrosarcoma

1975 • 33 citations

Factors influencing the immune response. I. Effects of the physical state of the antigen and of lymphoreticular cell proliferation on the response to intravenous injection of bovine serum albumin in rabbits.

1967 • 32 citations

Protection by Corynebacterium granulosum Against Radiation-Induced Enhancement of Artificial Pulmonary Metastases of a Murine Fibrosarcoma2

1974 • 31 citations

Brief Communication: In Vivo Cortisone Sensitivity of Nonspecific Antitumor Activity of Corynebacterium parvum-Activated Mouse Peritoneal Macrophages2

1975 • 31 citations

Effect of Adjuvants on the Antibody Response to a Hapten on a Thymus-independent Carrier

1972 • 30 citations

The delayed rejection of tumors formed from the administration of tumor cells mixed with killed corynebacterium parvum

1973 • 30 citations

Complete regressions of an established murine fibrosarcoma induced by systemic application of Corynebacterium granulosum.

1974 • 29 citations

Brief Communication : Regression of a Transplantable Hamster Melanoma by Intralesional Injections of Corynebacterium granulosum 2

1974 • 28 citations

Enhancement of resistance and suppression of immunization against experimental Trypanosoma cruzi infection by Corynebacterium parvum

1975 • 28 citations

Destruction of Hamster Ovarian Cell Cultures by Peritoneal Macrophages From Mice Treated With Corynebacterium granulosum

1974 • 28 citations

Combined Drug and Immunostimulation Therapy Against a Syngeneic Murine Leukemia

1974 • 28 citations

Synergistic Inhibition of Mammary Carcinoma Transplants in A-Strain Mice by Antitumour Globulin And C. parvum

1971 • 27 citations

AN ANALYSIS OF THE INHIBITORY EFFECT OF CORYNEBACTERIUM PARVUM ON GRAFT-VERSUS-HOST DISEASE

1967 • 27 citations

Nonspecific immunotherapy by corynebacteriumParvum. Phase I toxicity study in 12 patients with advanced cancer

1976 • 27 citations

A comparative study of anaerobic Coryneforms. Attempts to correlate their anti-tumour activity with their serological properties and ability to stimulate the lymphoreticular system.

1975 • 27 citations

The effect of gold salts on tumour immunity and its stimulation by Corynebacterium Parvum

1975 • 27 citations

MODIFICATIONS OF GRAFT-VERSUS-HOST REACTION INDUCED BY PRETREATMENT OF THE HOST WITH M. tuberculosis AND C. parvum

1965 • 27 citations

Antitumour effect of corynebacterium parvum. Possible mode of action

1976 • 26 citations

Chemical and Immunological Studies on the Cell Walls of Propionibacterium acnes Strain C7 and Corynebacterium parvum ATCC 11829

1975 • 26 citations

Effects of Corynebacterium granulosum on weight and histology of lymphoid organs, response to mitogens, skin allografts, and a syngeneic fibrosarcoma in mice.

1975 • 26 citations

Combination of C. parvum and specific immunization against artificial pulmonary metastases in mice

1975 • 25 citations

Radiation therapy andCorynebacterium parvum in the treatment of murine tumors

1976 • 24 citations

Factors influencing the immune response. 3. The blocking effect of Corynebacterium parvum upon the induction of acquired immunological unresponsiveness to bovine serum albumin in the adult rabbit.

1968 • 24 citations

Corynebacterium Parvum

1975 • 24 citations

In Vitro Destruction of Tumor Cells by Macrophages From Mice Treated With Corynebacterium granulosum2

1975 • 23 citations

Rejection of tumors and metastases in fischer 344 rats following intratumor administration of killed corynebacterium parvum

1974 • 23 citations

The accumulated effects of repeated systemic or local injections of low doses of Corynebacterium parvum in mice.

1976 • 23 citations

Possible Immunosuppressive Effect of Corynebacterium parvum on Infection with Trichinella spiralis

1973 • 22 citations

Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. 3. Depressed arrival of lymphoid cells at recently immunized lymph nodes in mice pretreated with adjuvants.

1972 • 21 citations

Effect of Corynebacterium acnes on Interferon Production in Mice

1972 • 21 citations

Immunostimulating Activity of Whole Cells, Cell-Walls and Fractions of Anaerobic Corynebacteria

1974 • 20 citations

Responsiveness of senescent mice to the antitumor properties of Corynebacterium parvum.

1976 • 19 citations

A cytochemical study of the in vitro interaction between normal and activated mouse peritoneal macrophages and tumor cells

1976 • 19 citations

Modifications in the handling in vitro of 125I-labelled keyhole limpet haemocyanin by peritoneal macrophages from mice pretreated with the adjuvant Corynebacterium parvum.

1975 • 19 citations

Adjuvant-induced antired blood cell activity in CBA mice.

1971 • 19 citations

HYBRID RESISTANCE TO PARENTAL WB/Re BONE MARROW GRAFTS

1972 • 18 citations

The role of macrophages in the amplified in vitro response to sheep red blood cells by spleen cells from Corynebacterium parvum treated mice

1975 • 18 citations

Hydrosoluble Immunopotentiating Substances Extracted from Corynebacterium Parvum

1974 • 17 citations

Lack of immunological and anti-tumour effects of orally administered Corynebacterium parvum in mice

1975 • 17 citations

Cellular Mechanisms Underlying the Adjuvant Activity ofCorynebucterium parvum: Interactions of Activated Macrophages with T and B Lymphocytes

2008 • 17 citations

Effect of <italic>Corynebacterium parvum</italic> on Cytotoxicity of Regional and Nonregional Lymph Node Cells From Animals With Tumors Present or Removed<xref ref-type="fn" rid="fn2">²</xref>

1974 • 17 citations

Mitogenicity of Corynebacterium parvum for mouse lymphocytes.

1975 • 16 citations

Paradoxical Effects of Immunopotentiators on Tumors and Tumor Viruses

1976 • 16 citations

The effect of Corynebacterium parvum therapy on immunoglobulin class and IgG subclass levels in cancer patients

1975 • 16 citations

The role of macrophages in the adjuvant effect on antibody production of Corynebacterium parvum.

1976 • 15 citations

Antitumor Antibodies and Immunoglobulin Class and Subclass Levels in Corynebacterium Parvum -Treated Mice

1976 • 15 citations

Radiation response of C3H fibrosarcoma enhanced in mice stimulated by Corynebacterium parvum

1975 • 15 citations

The effect of Corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer.

1976 • 14 citations

STUDIES ON THE HISTAMINE SENSITISATION PRODUCED IN MICE BY CORYNEBACTERIUM PARVUM

1973 • 14 citations

Study of the mechanism of Corynebacterium Parvum anti‐tumour activity. I. Protective effect on the growth of two syngeneic tumours

1976 • 14 citations

Corynebacterium parvum , A Potent Immunostimulant in Experimental Infections and in Malignancies

2008 • 13 citations

The Effect of Transplanted Methylcholanthrene Induced Fibrosarcomata and Corynebacterium parvum on the Immune Response of CBA and A/HeJ Mice to Thymus Dependent and Independent Antigens

1974 • 13 citations

Nonspecific Immunotherapy of Malignant Tumors

1976 • 13 citations

Antitumor activity of Corynebacterium parvum extracts.

1976 • 12 citations

Failure of Corynebacterium parvum Presensitization To Modify the Antitumor Effects of Systemic and Local Therapeutic Iniections of C. parvum in Mice 2

1976 • 12 citations

Effect of Corynebacterium parvum on cellular and humoral antitumoral immune effector mechanisms

1976 • 12 citations

Further Observations on the Inhibition of Tumor Growth by Corynebacterium parvum With Cyclophosphamide. II. Effect of Cortisone Acetate 2

1976 • 11 citations

The Effect of Corynebacterium parvum and other Reticuloendothelial Stimulants on Transplanted Tumours in Mice

2008 • 11 citations

Studies of the Corynebacterium parvum-associated anaemia in mice.

1974 • 11 citations

The Enhancement of Rabbit Anti-BSA IgE, Homocytotropic Antibody Production by Corynebacterium Parvum Strain 10387

1971 • 11 citations

The Influence of Mycobacterium Bovis and Corynebacterium Parvum on the Phospholipid Metabolism of Macrophages

1974 • 10 citations

Histological and combined chemoimmunostimulation therapy studies against a murine leukemia

1975 • 10 citations

"Xenogeneic resistance" to rat bone marrow transplantation. III. Maturation age, and abrogation with cyclophosphamide, Corynebacterium parvum and fractionated irradiation.

1976 • 10 citations

The Relation of Lymphocyte Trapping to the Mode of Action of Adjuvants

2008 • 9 citations

METHYL-CHOLANTHRENE-INDUCED SARCOMATA IN MICE AFTER IMMUNISATION WITH CORYNEBACTERIUM PARVUM PLUS SYNGENEIC SUBCELLULAR MEMBRANE FRACTIONS

1974 • 9 citations

Suppression of the incidence of death with spontaneous tumours in DBA/2 mice after Corynebacterium parvum-mediated rejection of syngeneic tumours

1976 • 9 citations

TOXICITY OF INTRAVENOUS CORYNEBACTERIUM PARVUM

1975 • 8 citations

Immunological Activity of Synthetic Cell-Wall Peptidoglycan Subunits

1976 • 8 citations

Quantitative effect of mycobacteria and of anaerobic corynebacteria upon immunogenic activity of azobenzearsonate‐n‐acetyl‐<scp>l</scp>‐tyrosine in guinea pigs

1973 • 7 citations

Effect of Corynebacterium acnes on interferon production in mouse peritoneal exudate cells

1975 • 7 citations

Therapy of spontaneous pulmonary metastases of a murine mammary carcinoma with anaerobic corynebacteria

1976 • 7 citations

Rejection of Mammary Adenocarcinoma Cell Tumors in DBA/2 Mice Immunocompromised by Thymectomy and Treatment with Antithymocyte Serum

1975 • 7 citations

Skin grafting across the H-Y barrier and the effect of biological adjuvants

1975 • 5 citations

Analysis of anaerobic coryneform cell wall antigens by radioimmunoassay

1975 • 5 citations

Modifications du nombre d'unités formatrices de colonies spléniques par des bactéries induisant i'immunostimulation non spécifique

1972 • 5 citations

Effect of Leupeptin, a Protease Inhibitor, on Induction of Bladder Tumors in Rats by N-Butyl-N- (4-hydroxybutyl ) nitrosamine23

1976 • 5 citations

CORYNEBACTERIUM PARVUM AND ANÆSTHETICS

1975 • 4 citations

The effect of drug therapy against a histologically defined rat leukemia.

1974 • 4 citations

Effect Of Immunisation With Heat-Killed Micro-Organisms on Transplantation Immunity to Adenovirus-12-Induced Tumour Cells

1974 • 3 citations

Chemotaxis of Macrophages: The Role of a Macro Phage-Specific Cytotaxin from Anaerobic Corynebacteria and its Relation to Immunopotentiationin vivo

2008 • 3 citations

Treatment of rat fibrosarcoma by radiotherapy plus immune adjuvant.

1976 • 3 citations

Effect of Corynebacterium Parvum on Resistance to Experimental Leukemia in Relation to Genetic Modification of Immunoresponsiveness

1974 • 2 citations

ANAEROBIC CORYNEBACTERIA AND ANÆSTHETICS

1975 • 2 citations