Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

A protein factor essential for microtubule assembly.

1975 • 2,863 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Colchicine-binding protein of mammalian brain and its relation to microtubules

1968 • 1,140 citations

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

1996 • 807 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

1994 • 704 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1993 • 702 citations

Reduction of β‐amyloid peptide₄₂ in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 684 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1992 • 625 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

1993 • 504 citations

Genetics of Aging

1997 • 493 citations

The Protein Phosphatases Involved in Cellular Regulation. 1. Classification and Substrate Specificities

1983 • 471 citations

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

1964 • 440 citations

Phosphatase Activity Toward Abnormally Phosphorylated τ: Decrease in Alzheimer Disease Brain

1995 • 428 citations

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1997 • 408 citations

The protein phosphatases involved in cellular regulation. Identification of the inhibitor-2 phosphatases in rabbit skeletal muscle

1984 • 330 citations

Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease

1996 • 325 citations

Brain Levels of Microtubule‐Associated Protein τ Are Elevated in Alzheimer's Disease: A Radioimmuno‐Slot‐Blot Assay for Nanograms of the Protein

1992 • 289 citations

Tubulin-nucleotide interactions during the polymerization and depolymerization of microtubules

1976 • 281 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Dephosphorylation of Alzheimer Paired Helical Filaments by Protein Phosphatase-2A and −2B

1995 • 264 citations

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1987 • 263 citations

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

1989 • 255 citations

Tau protein kinase I converts normal tau protein into A68-like component of paired helical filaments.

1992 • 246 citations

Elevation of microtubule-associated protein tau in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 223 citations

Hyperphosphorylation of Tau in PHF

1995 • 220 citations

Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain.

1992 • 196 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease

1991 • 177 citations

Morphology of the Aging Brain, Human and Animal

1973 • 171 citations

Levels of normal and abnormally phosphorylated tau in different cellular and regional compartments of Alzheimer disease and control brains

1994 • 158 citations

Restoration of biological activity of Alzheimer abnormally phosphorylated τ by dephosphorylation with protein phosphatase-2A, −2B and −1

1996 • 155 citations

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A

1994 • 151 citations

Alzheimer paired helical filaments Restoration of the biological activity by dephosphorylation

1994 • 151 citations

Alzheimer's Disease Abnormally Phosphorylated τ Is Dephosphorylated by Protein Phosphatase‐2B (Calcineurin)

1994 • 142 citations

Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios

1991 • 134 citations

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

1988 • 125 citations

Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s)

1984 • 106 citations

About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation

1989 • 105 citations

Dephosphorylation of microtubule‐associated protein tau by protein phosphatase‐1 and ‐2C and its implication in Alzheimer disease

1994 • 96 citations

Brain ubiquitin is markedly elevated in Alzheimer disease

1991 • 86 citations

Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals

1994 • 76 citations

Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels

1994 • 69 citations

Ultrastructure of Senile Dementia and of Experimental Analogs

1972 • 61 citations

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

1994 • 53 citations

Alzheimer's disease: paired helical filament immunoreactivity in cerebrospinal fluid

1991 • 46 citations

Alzheimer abnormally phosphorylated tau is more hyperphosphorylated than the fetal tau and causes the disruption of microtubules

1995 • 29 citations

Guanosine Triphosphate Binding to β‐Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule‐Associated Protein τ

1995 • 25 citations

The phosphatase inhibitor okadaic acid induces a phosphorylated paired helical filament tau epitope in human LA-N-5 neuroblastoma cells

1993 • 23 citations