Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Metabolic stability and epigenesis in randomly constructed genetic nets

1969 • 4,565 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

The logical analysis of continuous, non-linear biochemical control networks

1973 • 958 citations

Boolean formalization of genetic control circuits

1973 • 921 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Receptors; models for binding, trafficking and signaling

1997 • 883 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Circuit Simulation of Genetic Networks

1995 • 518 citations

Dynamical behaviour of biological regulatory networks—I. Biological role of feedback loops and practical use of the concept of the loop-characteristic state

1995 • 476 citations

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

1992 • 471 citations

The Insulin-Like Growth Factor-I Receptor

1994 • 325 citations

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

1993 • 323 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

1994 • 282 citations

Classification of biological networks by their qualitative dynamics

1975 • 231 citations

4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice

1995 • 231 citations

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

1993 • 224 citations

Insulin-like Growth Factors: Molecular and Cellular Aspects

1992 • 214 citations

Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

1996 • 187 citations

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor

1997 • 184 citations

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1995 • 184 citations

Co-operative components, spatial localization and oscillatory cellular dynamics

1972 • 161 citations

Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

1995 • 154 citations

Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways

1996 • 153 citations

Towards a logical analysis of the immune response

1985 • 152 citations

Logical analysis of systems comprising feedback loops

1978 • 147 citations

Insulin-stimulated GLUT4 Translocation Is Mediated by a Divergent Intracellular Signaling Pathway

1995 • 146 citations

The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake

1992 • 144 citations

The Metabolic Regulation and Vesicular Transport of GLUT4, the Major Insulin-Responsive Glucose Transporter*

1995 • 142 citations

SCAMP: a general-purpose simulator and metabolic control analysis program

1993 • 120 citations

Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities

1991 • 116 citations

Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1

1995 • 86 citations

A machine-independent language for the simulation of complex chemical and biochemical systems

1968 • 75 citations

Mechanism of Insulin and IGF‐I

1995 • 67 citations

Inactivation of MAP kinases

1994 • 62 citations

Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases

1995 • 58 citations

Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes.

1992 • 57 citations

Insulin dependence of murine lymphoid T‐cell leukemia

1992 • 33 citations

Luteinizing hormone pulse frequency is increased by arginine infusion in prepubertal sheep

2009 • 18 citations

Boolean analysis of cell regulation networks

1983 • 18 citations